Répertoire du corps professoral
Amélie Boutin
Professeure sous octroi adjointe
(418) 525-4444, poste 47069
amelie.boutin@fmed.ulaval.ca
Pavillon Ferdinand-Vandry
1050, avenue de la Médecine
Chaire Jeanne-et-Jean-Louis-Lévesque en périnatalogie
Programme: Chaire de recherche en partenariat
Organisme(s) subventionnaire(s): Fondation de l'Université Laval
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2024
au 30 juin 2026
L'inversion de la pyramide des soins anténataux pour améliorer l'accès aux soins et la santé des mères et des enfants vivant en région éloignée (PROJET PYRAMIDE)
Programme: Subvention de fonctionnement : Initiative nationale de recherche sur la santé des femmes (INRHN) : Foire aux questions sur le Fonds d’innovation
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juin 2024
au 31 mars 2027
Détresse psychologique maternelle et impacts sur les enfants
Organisme(s) subventionnaire(s): Fondation du CHU de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 mai 2024
au 31 mars 2025
GROWW (Guiding interdisciplinary Research On cis- and trans-genderWomen's and girls health and Wellbeing)
Programme: Projet de Plateforme de formation en recherche en santé
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: University of Calgary
Du 1 janvier 2022
au 31 décembre 2027
Subvention d'établissement de jeune chercheur
Programme: Établissement de jeunes chercheurs - Juniors 1
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 30 août 2020
au 31 août 2025
Évaluation de la qualité des services de soins de santé périnatale
Programme: Chercheur-boursier Juniors 1 et 2, Seniors
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé, Fonds de recherche du Québec (FRQ «trois secteurs ensemble»)
Type de financement: Subvention
Établissement tête: Université Laval
Du 30 août 2020
au 31 août 2025
Financements des 2 dernières années
Facteurs de risque liés aux blessures non intentionnelles sévères et mortelles chez l’enfant : revue systématique de la littérature
Programme: Aide à la recherche
Organisme(s) subventionnaire(s): CHU de Québec – Université Laval – CHUL
Type de financement: Subvention
Établissement tête: Université Laval
Du 12 décembre 2023
au 31 mars 2024
Fonds de démarrage. Amélie Boutin
Programme: Fonds de démarrage
Organisme(s) subventionnaire(s): CHU de Québec – Université Laval – CHUL, Fondation du CHU de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 31 août 2020
au 30 août 2023
Programme de soutien aux nouveaux chercheurs
Programme: Soutien facultaire aux jeunes chercheurs de la Faculté de médecine
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 30 août 2020
au 29 août 2023
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
Risk factors for severe and fatal childhood unintentional injury: a systematic review protocol. Systematic reviews, 2024/07. Beaulieu E, Herrera NMP, Boutin A. DOI 10.1186/s13643-024-02612-2
Corrigendum to Database Autopsy: An Efficient and Effective Confidential Enquiry into Maternal Deaths in Canada Journal of Obstetrics and Gynaecology Canada (JOGC). Volume 43, Issue 1 (2021) 58-66. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2024/07. Boutin A, Cherian A, Liauw J, Dzakpasu S, Scott H, Van den Hof M, Cook J, Blake J, Joseph KS, Canadian Perinatal Surveillance System (Public Health Agency of Canada). DOI 10.1016/j.jogc.2024.102615
Why improved surveillance is critical for reducing maternal deaths in the United States: A response to the American College of Obstetricians and Gynecologists. American journal of obstetrics and gynecology, 2024/05. Joseph KS, Lisonkova S, Boutin A, Muraca GM, Razaz N, John S, Sabr Y, Chan WS, Mehrabadi A, Brandt JS, Schisterman EF, Ananth CV. DOI 10.1016/j.ajog.2024.05.003
Temporal changes in maternal mortality in the United States. American journal of obstetrics and gynecology, 2024/05. Joseph KS, Lisonkova S, John S, Sabr Y, Boutin A, Muraca GM, Razaz N, Chan WS, Mehrabadi A, Brandt JS, Schisterman EF, Ananth CV. DOI 10.1016/j.ajog.2024.04.056
Risk factors for severe and fatal childhood unintentional injury: A systematic review protocol 2024/02. Beaulieu E, Herrera NMP, Boutin A. DOI 10.21203/rs.3.rs-3848055/v1
Maternal mortality in the United States: are the high and rising rates due to changes in obstetrical factors, maternal medical conditions, or maternal mortality surveillance? American journal of obstetrics and gynecology, 2024/02. Joseph KS, Lisonkova S, Boutin A, Muraca GM, Razaz N, John S, Sabr Y, Chan WS, Mehrabadi A, Brandt JS, Schisterman EF, Ananth CV. DOI 10.1016/j.ajog.2023.12.038
Aspirin at 75 to 81 mg Daily for the Prevention of Preterm Pre-Eclampsia: Systematic Review and Meta-Analysis Journal of Clinical Medicine, 2024/02. Brielle Demuth, Ariane Pellan, Amélie Boutin, Emmanuel Bujold, Louise Ghesquière. DOI 10.3390/jcm13041022
Mining the Gap: Deriving Pregnancy Reference Intervals for Hematology Parameters Using Clinical Datasets. Clinical chemistry, 2023/12. Barakauskas VE, Bohn MK, Branch E, Boutin A, Albert A, Luke S, Dittrick M, Higgins V, Adeli K, Vallance H, Jung B, Dooley K, Dahlgren-Scott L, Chan WS. DOI 10.1093/clinchem/hvad167
Erratum to Technical Update No. 438: Antenatal Corticosteroids at Late Preterm Gestation Journal of Obstetrics and Gynaecology Canada 2023; 45(6): 445-457.E2. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2023/12. Liauw J, Foggin H, Socha P, Crane J, Joseph KS, Burrows J, Lacaze-Masmonteil T, Jain V, Boutin A, Hutcheon J. DOI 10.1016/j.jogc.2023.102270
Effect of the COVID-19 Pandemic on Stillbirths in Canada and the United States. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2023/12. Joseph KS, Lisonkova S, Simon S, John S, Razaz N, Muraca GM, Boutin A, Bedaiwy MA, Brandt JS, Ananth CV. DOI 10.1016/j.jogc.2023.102338
Obstetric Intervention and Perinatal Outcomes During the Coronavirus Disease 2019 (COVID-19) Pandemic. Obstetrics and gynecology, 2023/10. Simon S, John S, Lisonkova S, Razaz N, Muraca GM, Boutin A, Bedaiwy MA, Brandt JS, Ananth CV, Joseph KS. DOI 10.1097/aog.0000000000005412
Determinants of perioperative complications in day-surgery for endometriosis: A retrospective cohort. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2023/09. Bahrami F, Maheux-Lacroix S, Bougie O, Boutin A. DOI 10.1016/j.jogc.2023.102227
Enteral supplementation with high-dose docosahexaenoic acid on the risk of bronchopulmonary dysplasia in very preterm infants: a collaborative study protocol for an individual participant data meta-analysis. BMJ open, 2023/07. Marc I, Lavoie PM, McPhee AJ, Collins CT, Simonyan D, Pronovost E, Guillot M, Gould JF, Mohamed I, Beltempo M, Boutin A, Fortier I, Sullivan TR, Makrides M. DOI 10.1136/bmjopen-2023-076223
Day surgery for endometriosis in Canada: A retrospective cohort of trend and regional variation in types of surgeries and their complications. The Australian & New Zealand journal of obstetrics & gynaecology, 2023/06. Bahrami F, Maheux-Lacroix S, Bougie O, Boutin A. DOI 10.1111/ajo.13705
Understanding what patients and physicians need to improve their decision-making about antenatal corticosteroids in late preterm gestation: a qualitative framework analysis. CMAJ open, 2023/05. Foggin H, Metcalfe R, Hutcheon JA, Bansback N, Burrows J, Karacebeyli E, Shivananda S, Boutin A, Liauw J. DOI 10.9778/cmajo.20220139
Complications following surgeries for endometriosis: A systematic review protocol. PloS one, 2023/05. Bahrami F, Maheux-Lacroix S, Bougie O, Boutin A. DOI 10.1371/journal.pone.0285929
Response to the Commentary 'Causes of ART-related outcomes in the COVID-19 era'. Paediatric and perinatal epidemiology, 2023/04. Lisonkova S, Bone JN, Muraca GM, Razaz N, Boutin A, Brandt JS, Bedaiwy MA, Ananth CV, Joseph KS. DOI 10.1111/ppe.12980
Association Between Enteral Supplementation With High-Dose Docosahexaenoic Acid and Risk of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review and Meta-analysis. JAMA network open, 2023/03. Marc I, Boutin A, Pronovost E, Perez Herrera NM, Guillot M, Bergeron F, Moore L, Sullivan TR, Lavoie PM, Makrides M. DOI 10.1001/jamanetworkopen.2023.3934
Hospital factors associated with maternal and neonatal outcomes of deliveries to patients with a previous cesarean delivery: an ecological study. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2023/02. Joseph KS, Young CB, Muraca GM, Boutin A, Razaz N, John S, Lisonkova S, Wilson RD. DOI 10.1503/cmaj.220928
Time of Delivery Among Low-Risk Women at 37-42 Weeks of Gestation and Risks of Stillbirth and Infant Mortality, and Long-term Neurological Morbidity Obstetrical and Gynecological Survey, 2023. Razaz, N., Muraca, G.M., Fink, K., Boutin, A., John, S., Lisonkova, S., Stephansson, O., Cnattingius, S., Joseph, K.S.. DOI 10.1097/OGX.0000000000001122
Technical Update No. 439: Antenatal Corticosteroids at Late Preterm Gestation. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2022/12. Liauw J, Foggin H, Socha P, Crane J, Joseph KS, Burrows J, Lacaze-Masmonteil T, Jain V, Boutin A, Hutcheon J. DOI 10.1016/j.jogc.2022.12.006
Mise à jour technique n<sup>o</sup> 439 : Corticothérapie prénatale en période de prématurité tardive. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2022/12. Liauw J, Foggin H, Socha P, Crane JM, Joseph KS, Burrows J, Lacaze-Masmonteil T, Jain V, Boutin A, Hutcheon J. DOI 10.1016/j.jogc.2022.12.007
High doses of enteral docosahexaenoic acid omega-3 supplementation for prevention of bronchopulmonary dysplasia in very preterm infants: a protocol for a systematic review and meta-analysis. BMJ open, 2022/10/17. Amélie Boutin, Marc I, Boutin A, Etienne Pronovost, Mireille Guillot, Bergeron F, Moore L, Makrides M. DOI 10.1136/bmjopen-2022-064515
Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth. Paediatric and perinatal epidemiology, 2022/08/29. Sarka Lisonkova, Jeffrey Bone, Muraca GM, Neda Razaz, Amélie Boutin, Justin Brandt, Bedaiwy MA, Cande Ananth, K.S. Joseph. DOI 10.1111/ppe.12925
Time of delivery among low-risk women at 37-42 weeks of gestation and risks of stillbirth and infant mortality, and long-term neurological morbidity. Paediatric and perinatal epidemiology, 2022/03/04. Neda Razaz, Giulia M Muraca, Fink K, Amélie Boutin, Sid John, Sarka Lisonkova, Olof Stephansson, Sven Cnattingius, K.S. Joseph. DOI 10.1111/ppe.12868
Pregnant people's responses to the COVID-19 pandemic: a mixed-methods, descriptive study. CMAJ open, 2022/01/01. Hamideh Bayrampour, Tamana SK, Amélie Boutin. DOI 10.9778/cmajo.20210136
Maternal and neonatal trauma following operative vaginal delivery. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2022/01/01. Giulia M Muraca, Amélie Boutin, Razaz N, Sarka Lisonkova, John S, J Ting; JY Ting, Scott H, Kramer MS, Joseph KS. DOI 10.1503/cmaj.210841
Time trends, geographic variation and risk factors for gastroschisis in Canada: A population-based cohort study 2006-2017. Paediatric and perinatal epidemiology, 2021/09. Liu S, Evans J, Boutin A, Luo W, Gheorghe M, Auger N, Arbour L, Moore A, Joseph KS, Little J. DOI 10.1111/ppe.12800
Causal and prognostic perspectives in obstetrics. American journal of obstetrics & gynecology MFM, 2021/09. Boutin A, Joseph KS. DOI 10.1016/j.ajogmf.2021.100483
Bias in comparisons of mortality among very preterm births: A cohort study PLOS ONE, 2021/06/30. DOI 10.1371/journal.pone.0253931
Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol. Systematic reviews, 2021/06. Laflamme M, Haghbayan H, Lalu MM, Zarychanski R, Lauzier F, Boutin A, Macleod MR, Fergusson DA, Moore L, Costerousse O, Lacroix J, Wellington C, Canadian Traumatic Brain Injury Research Consortium. DOI 10.1186/s13643-021-01703-8
Maternal and Perinatal Outcomes of Expectant Management of Full-Term, Low-Risk, Nulliparous Patients. Obstetrics and gynecology, 2021/06. Boutin A, Joseph KS. DOI 10.1097/aog.0000000000004416
Incidence and risk factors for severe preeclampsia, HELLP syndrome and eclampsia at preterm and term gestation: a population-based study. American journal of obstetrics and gynecology, 2021/05. Lisonkova S, Bone JN, Muraca GM, Razaz N, Wang LQ, Sabr Y, Boutin A, Mayer C, Joseph KS. DOI 10.1016/j.ajog.2021.04.261
Maternal Mortality in the United States: Recent Trends, Current Status, and Future Considerations. Obstetrics and gynecology, 2021/05/01. DOI 10.1097/aog.0000000000004361
Aspirin Responsiveness at a Dose of 80 mg and Its Impact on Birth Weight when Used in Twin Pregnancies: The GAP Pilot Randomized Trial. American journal of perinatology, 2021/04/21. DOI 10.1055/s-0041-1727215
Pregnancy outcomes in nulliparous women with positive first-trimester preterm preeclampsia screening test: the Great Obstetrical Syndromes cohort study American Journal of Obstetrics and Gynecology, 2021. Boutin, A., Guerby, P., Gasse, C., Tapp, S., Bujold, E.. DOI 10.1016/j.ajog.2020.08.008
Modern obstetrics: beyond early delivery for fetal or maternal compromise American journal of obstetrics & gynecology MFM, 2021. Joseph, K.S., John, S., Boutin, A., Scime, N.V., Chaput, K.H., Muraca, G.M., Razaz, N., Sabr, Y., Lisonkova, S., Dendukuri, N.. DOI 10.1016/j.ajogmf.2020.100274
Database Autopsy: An Efficient and Effective Confidential Enquiry into Maternal Deaths in Canada Journal of Obstetrics and Gynaecology Canada, 2021. Boutin, A., Cherian, A., Liauw, J., Dzakpasu, S., Scott, H., Van den Hof, M., Cook, J., Blake, J., Joseph, K.S.. DOI 10.1016/j.jogc.2020.06.026
Contextual performance of diagnostics for fetal surveillance BJOG: An International Journal of Obstetrics and Gynaecology, 2021. Boutin, A., Joseph, K.S.. DOI 10.1111/1471-0528.16334
First-Trimester Preterm Preeclampsia Screening in Nulliparous Women: The Great Obstetrical Syndrome (GOS) Study Journal of Obstetrics and Gynaecology Canada, 2021/01/01. DOI 10.1016/j.jogc.2020.06.011
Red Blood Cell Transfusion in Animal Models of Acute Brain Injuries: A Systematic Review Protocol 2020/10. Laflamme M, Haghbayan H, Lalu MM, Zarychanski R, Lauzier F, Boutin A, Macleod MR, Fergusson DA, Moore L, Costerousse O, Lacroix J, Wellington C, Turgeon AF. DOI 10.21203/rs.3.rs-97823/v1
Red Blood Cell Transfusion in Animal Models of Acute Brain Injuries: A Systematic Review Protocol ResearchSquare, 2020. Laflamme, M., Haghbayan, H., Lalu, M.M., Zarychanski, R., Lauzier, F., Boutin, A., Macleod, M.R., Fergusson, D.A., Moore, L., Costerousse, O., Lacroix, J., Wellington, C., Hutchison, J., Turgeon, A.F.. DOI 10.21203/rs.3.rs-97823
Maternal risk factors and adverse birth outcomes associated with HELLP syndrome: a population-based study BJOG: An International Journal of Obstetrics and Gynaecology, 2020. Lisonkova, S., Razaz, N., Sabr, Y., Muraca, G.M., Boutin, A., Mayer, C., Joseph, K.S., Kramer, M.S.. DOI 10.1111/1471-0528.16225
First Trimester Mean Arterial Pressure Measured Manually Versus Using an Automated Device and the Prediction of Preeclampsia: A Case-Cohort Study Journal of Obstetrics and Gynaecology Canada, 2020. Côté, M., Boutin, A., Gasse, C., Demers, S., Bujold, E.. DOI 10.1016/j.jogc.2019.06.017
Endometrial ablation or resection versus levonorgestrel intra-uterine system for the treatment of women with heavy menstrual bleeding and a normal uterine cavity: A systematic review with meta-analysis Human Reproduction Update, 2020. Bergeron, C., Laberge, P.Y., Boutin, A., Thériault, M.-A., Valcourt, F., Lemyre, M., Maheux-Lacroix, S.. DOI 10.1093/humupd/dmz051
Endometrial Ablation or Resection Versus Levonorgestrel Intra-uterine System for the Treatment of Women with Heavy Menstrual Bleeding and a Normal Uterine Cavity: A Systematic Review with Meta-analysis Obstetrical and Gynecological Survey, 2020. Bergeron, C., Laberge, P.Y., Boutin, A., Thériault, M.-A., Valcourt, F., Lemyre, M., Maheux-Lacroix, S.. DOI 10.1097/01.ogx.0000689536.35775.11
Effect of age at vaccination on the measles vaccine effectiveness and immunogenicity: Systematic review and meta-Analysis BMC Infectious Diseases, 2020. Carazo, S., Billard, M.-N., Boutin, A., De Serres, G.. DOI 10.1186/s12879-020-4870-x
Diagnostic Accuracy of Intraoperative Tools for Detecting Endometriosis: A Systematic Review and Meta-analysis Journal of Minimally Invasive Gynecology, 2020. Maheux-Lacroix, S., Belanger, M., Pinard, L., Lemyre, M., Laberge, P., Boutin, A.. DOI 10.1016/j.jmig.2019.11.010
Use of Antenatal Corticosteroid Therapy: A Descriptive Study of Clinical Practice Trends Journal of Obstetrics and Gynaecology Canada, 2019. Fillion, A., Boutin, A., Gareau-Léonard, A., Labine, L., Gasse, C., Gaudreau, C., Demers, S., Bujold, E.. DOI 10.1016/j.jogc.2018.06.001
Temporal Trends in Preterm Birth, Neonatal Mortality, and Neonatal Morbidity Following Spontaneous and Clinician-Initiated Delivery in Canada, 2009-2016 Journal of Obstetrics and Gynaecology Canada, 2019. Richter, L.L., Ting, J., Muraca, G.M., Boutin, A., Wen, Q., Lyons, J., Synnes, A., Lisonkova, S.. DOI 10.1016/j.jogc.2019.02.151
Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians’ attitudes,Transfusion d’érythrocytes chez les patients en état critique atteints de traumatisme cérébral : une enquête de pratique internationale des médecins Canadian Journal of Anesthesia, 2019. Lessard Bonaventure, P., Lauzier, F., Zarychanski, R., Boutin, A., Shemilt, M., Saxena, M., Zolfagari, P., Griesdale, D., Menon, D.K., Stanworth, S., English, S., Chassé, M., Fergusson, D.A., Moore, L., Kramer, A., Robitaille, A., Myburgh, J., Cooper, J., Hutchinson, P., Turgeon, A.F.. DOI 10.1007/s12630-019-01369-w
Prognostic Value of Glial Fibrillary Acidic Protein in Patients with Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis Critical Care Medicine, 2019. Shemilt, M., Boutin, A., Lauzier, F., Zarychanski, R., Moore, L., McIntyre, L.A., Nadeau, L., Fergusson, D.A., Mercier, E., Archambault, P., Lamontagne, F., Perron, C., Léger, C., Turgeon, A.F.. DOI 10.1097/CCM.0000000000003728
Impact of Audits and Multifaceted Intervention on Vaginal Birth After Caesarean: Secondary Analysis of the QUARISMA Trial Journal of Obstetrics and Gynaecology Canada, 2019. Roberge, S., Boutin, A., Bujold, E., Dubé, E., Blouin, S., Chaillet, N.. DOI 10.1016/j.jogc.2018.05.044
First-Trimester Uterine Artery Doppler for the Prediction of Preeclampsia in Nulliparous Women: The Great Obstetrical Syndrome Study American Journal of Perinatology, 2019. Demers, S., Boutin, A., Gasse, C., Drouin, O., Girard, M., Bujold, E.. DOI 10.1055/s-0038-1675209
First-Trimester Placental Growth Factor for the Prediction of Preeclampsia in Nulliparous Women: The Great Obstetrical Syndromes Cohort Study Fetal Diagnosis and Therapy, 2019. Boutin, A., Demers, S., Gasse, C., Giguère, Y., Tétu, A., Laforest, G., Bujold, E.. DOI 10.1159/000487301
Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury CMAJ, 2019. Turgeon, A.F., Dorrance, K., Archambault, P., Lauzier, F., Lamontagne, F., Zarychanski, R., Fowler, R., Moore, L., Lacroix, J., English, S., Boutin, A., Muscedere, J., Burns, K.E.A., Griesdale, D., McIntyre, L.A., Scales, D., Bernard, F., Yamada, J., Squires, J.E.. DOI 10.1503/cmaj.190154
Delivery options and risk of severe acute maternal morbidity CMAJ, 2019. Joseph, K.S., Boutin, A., Lisonkova, S.. DOI 10.1503/cmaj.72609
Body mass index and the risk of hypertensive disorders of pregnancy: the great obstetrical syndromes (GOS) study Journal of Maternal-Fetal and Neonatal Medicine, 2019. Gasse, C., Boutin, A., Demers, S., Chaillet, N., Bujold, E.. DOI 10.1080/14767058.2017.1399117
Associations between Migraine and Adverse Pregnancy Outcomes: Systematic Review and Meta-analysis Obstetrical and Gynecological Survey, 2019. Aukes, A.M., Yurtsever, F.N., Boutin, A., Visser, M.C., De Groot, C.J.M.. DOI 10.1097/OGX.0000000000000738
Association between fertility treatments and early placentation markers Placenta, 2019. Côté, A., Maheux-Lacroix, S., Sabr, Y., Gasse, C., Bujold, E., Boutin, A.. DOI 10.1016/j.placenta.2019.05.010
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