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Danielle Laurin

Professeure titulaire
(418) 682-7511, poste 84832
Danielle.Laurin@pha.ulaval.ca
Université Laval, Hôpital du St-Sacrement
1050, chemin Sainte-Foy

Unité de rattachement — Faculté
Pharmacie

Affiliations
Institut sur le vieillissement et la participation sociale des aînés
VITAM - Centre de recherche en santé durable
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en santé durable (VITAM)

Étude de la sélénonéine en tant que nouveau biomarqueur nutritionnel et agent thérapeutique dans les maladies neurodégénératives
Programme: Projet subsidiaire d'un regroupement stratégique
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université Laval
Du 18 décembre 2024 au 31 mars 2026

Vieillissement et troubles neurocognitifs: identification de biomarqueurs cérébraux et stresseurs psychosociaux au travail
Organisme(s) subventionnaire(s): Fondation de l'Université Laval
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 janvier 2024 au 31 décembre 2026

Est-ce que les approches pharmaco-nutritionnelles préconisées en prévention cardiovasculaire protègent aussi contre les troubles neurocognitifs?
Programme: Projet subsidiaire d'un regroupement stratégique
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au 31 mars 2025

Prévenir l’hypertension, le diabète de type 2 et les maladies cardiovasculaires en ciblant les stresseurs psychosociaux au travail, les longues heures de travail et les mauvaises habitudes de vie : Des fractions
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2022 au 31 mars 2026

Financements des 2 dernières années

Phase Two of the Canadian Consortium on Neurodegeneration in Aging
Programme: Consortium canadien en neurodégénérescence et vieillissement (CCNV)
Organisme(s) subventionnaire(s): Société Alzheimer du Canada, Centre for Aging + Brain Health Innovation, Saskatchewan Health Research Foundation, Hypertension Canada, Instituts de recherche en santé du Canada, Fondation des infirmières et infirmiers du Canada, Brain Canada Foundation, Fondation de la recherche en santé du Nouveau-Brunswick
Type de financement: Subvention
Établissement tête: University of Toronto
Du 1 avril 2019 au 31 mars 2024

Encadrements terminés dans les 5 dernières années

  • Virginie Drolet-Labelle, Maîtrise en nutrition - avec mémoire
  • Gisele Beltrao Barcelos Vincler, Maîtrise en épidémiologie - avec mémoire
  • Caroline Duchaine, Doctorat en épidémiologie
  • David Mumbere Bamusemba, Maîtrise en sciences pharmaceutiques - pharmaco-épidémiologie - avec mémoire
  • Publications des 5 dernières années

    Effort-reward imbalance at work assessed at midlife and prediabetes prevalence assessed 18 years later in a prospective cohort of white-collar workers Annals of Work Exposures and Health, 2024/11/25. Camille Riopel, Xavier Trudel, Alain Milot, Danielle Laurin, Mahée Gilbert-Ouimet, Chantal Brisson. DOI 10.1093/annweh/wxae071

    Biological Markers of Musculoskeletal Pain: A Scoping Review Journal of Pain Research, 2024/10. Codjo Djignefa Djade, Caroline Diorio, Danielle Laurin, Septime Pepin Hector Hessou, Alfred Kodjo Toi, Amédé Gogovor, Aboubacar Sidibe, Giraud Ekanmian, Teegwendé Valérie Porgo, Hervé Tchala Vignon Zomahoun, Clermont E Dionne. DOI 10.2147/JPR.S472934

    Psychosocial Stressors at Work and Coronary Heart Disease Risk in Men and Women: 18-Year Prospective Cohort Study of Combined Exposures Circulation: Cardiovascular Quality and Outcomes, 2023/10. Mathilde Lavigne-Robichaud, Xavier Trudel, Denis Talbot, Alain Milot, Mahée Gilbert-Ouimet, Michel Vézina, Danielle Laurin, Clermont E. Dionne, Neil Pearce, Gilles R. Dagenais, Chantal Brisson. DOI 10.1161/CIRCOUTCOMES.122.009700

    Effort-reward imbalance at work, glycated hemoglobin and prediabetes prevalence in a prospective cohort 2023/01/09. C Riopel, X Trudel, A Milot, D Laurin, M Gilbert-Ouimet, C Brisson. DOI 10.1101/2023.01.07.23284201

    Beliefs underlying older adults' intention to consume plant-based protein foods: A qualitative study Appetite, 2023/01. Virginie Drolet-Labelle, Danielle Laurin, Alexandra Bédard, Vicky Drapeau, Sophie Desroches. DOI 10.1016/j.appet.2022.106346

    Effect of APOE ε4 allele and redox signature in circulating extracellular vesicles in cognitively impaired patients converted to Alzheimer's disease Free Radical Biology and Medicine, 2022/08. Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy. DOI 10.1016/j.freeradbiomed.2022.06.059

    Serum ω-3 Fatty Acids and Cognitive Domains in Community-Dwelling Older Adults from the NuAge Study: Exploring the Associations with Other Fatty Acids and Sex The Journal of Nutrition, 2022/05. Caroline S Duchaine, Alexandra J Fiocco, Pierre-Hugues Carmichael, Stephen C Cunnane, Mélanie Plourde, Aurélie Lampuré, Benjamin Allès, Sylvie Belleville, Pierrette Gaudreau, Nancy Presse, Guylaine Ferland, Danielle Laurin. DOI 10.1093/jn/nxac110

    An exploratory identification of biological markers of chronic musculoskeletal pain in the low back, neck, and shoulders PLOS ONE, 2022/04. Codjo Djignefa Djade, Caroline Diorio, Danielle Laurin, Clermont E. Dionne. DOI 10.1371/journal.pone.0266999

    The Association Between Self-Reported Cigarette Smoking and Spinal Pain is Not Explained by Serum Cotinine Levels Annals of Epidemiology, 2022/03. Clermont E. Dionne, Danielle Laurin, Thérèse Desrosiers, Belkacem Abdous, Natalie Le Sage, Jérôme Frenette, Myrto Mondor. DOI 10.1016/j.annepidem.2021.12.006

    Effect of APOE ε4 Allele on Levels of Apolipoproteins E, J, and D, and Redox Signature In Circulating Extracellular Vesicles from Cognitively Impaired with No Dementia Participants Converted to Alzheimer’s Disease Free Radical Biology and Medicine, 2022/02. Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy. DOI 10.1016/j.freeradbiomed.2021.12.242

    Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies Nature Communications, 2021/12. DOI 10.1038/s41467-021-22370-2

    Psychosocial stressors at work and inflammatory biomarkers: PROspective Quebec Study on Work and Health Psychoneuroendocrinology, 2021/11. Caroline S. Duchaine, Chantal Brisson, Denis Talbot, Mahée Gilbert-Ouimet, Xavier Trudel, Michel Vézina, Alain Milot, Caroline Diorio, Ruth Ndjaboué, Yves Giguère, Benoît Mâsse, Clermont E. Dionne, Elizabeth Maunsell, Danielle Laurin. DOI 10.1016/j.psyneuen.2021.105400

    Effect of <i>APOE</i> ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer's disease Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021/09. Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy. DOI 10.1002/dad2.12231

    Discontinuation of bisphosphonates in seniors: a systematic review on health outcomes Archives of Osteoporosis, 2021/09. Marianne Lamarre, Martine Marcotte, Danielle Laurin, Daniela Furrer, Isabelle Vedel, André Tourigny, Anik Giguère, Pierre-Hugues Carmichael, Rosa Martines, José Morais, Edeltraut Kröger. DOI 10.1007/s11657-021-01000-w

    Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis Hypertension, 2021/09. Jean K. Ho, Frank Moriarty, Jennifer J. Manly, Eric B. Larson, Denis A. Evans, Kumar B. Rajan, Elizabeth M. Hudak, Lamiaa Hassan, Enwu Liu, Nobuyuki Sato, Naoyuki Hasebe, Danielle Laurin, Pierre-Hugues Carmichael, Daniel A. Nation. DOI 10.1161/hypertensionaha.121.17049

    Cumulative exposure to psychosocial stressors at work and global cognitive function: the PROspective Quebec Study on Work and Health Occupational and Environmental Medicine, 2021/07/06. Caroline S. Duchaine, Chantal Brisson, Denis Talbot, Mahée Gilbert-Ouimet, Xavier Trudel, Michel Vézina, Alain Milot, Caroline Diorio, Ruth Ndjaboué, Yves Giguère, Benoît Mâsse, Clermont E Dionne, Elizabeth Maunsell, Danielle Laurin. DOI 10.1136/oemed-2021-107407

    The impact of adjusting for pure predictors of exposure, mediator, and outcome on the variance of natural direct and indirect effect estimators Statistics in Medicine, 2021/03. Awa Diop, Geneviève Lefebvre, Caroline S. Duchaine, Danielle Laurin, Denis Talbot. DOI 10.1002/sim.8906

    Plasma Long Chain Fatty Acids and Cognitive Function in Older Adults: A Comparison of Statistical Analyses Innovation in Aging, 2021. Caroline Duchaine, Pierre-Hugues Carmichael, Nancy Presse, Alexandra Fiocco, Pierrette Gaudreau, Guylaine Ferland, Danielle Laurin. DOI 10.1093/geroni/igab046.048

    Is arthritis associated with cardiovascular diseases in both sexes? An analysis of NHANES data Rhumatology and Orthopedic Medicine, 2021.

    Health Impacts and Characteristics of Deprescribing Interventions in Older Adults: Protocol for a Systematic Review and Meta-analysis JMIR Research Protocols, 2021. Zoë Tremblay, David Mumbere, Danielle Laurin, Caroline Sirois, Daniela Furrer, Lise Poisblaud, Pierre-Hugues Carmichael, Barbara Farrell, André Tourigny, Anik Giguere, Isabelle Vedel, José Morais, Edeltraut Kröger. DOI 10.2196/25200

    Apolipoprotein E4‐driven effects on inflammatory and neurotrophic factors in peripheral extracellular vesicles from cognitively impaired not demented participants converted to Alzheimer’s disease Alzheimer's & Dementia, 2021. Mohamed Raâfet Ben Kheder, Mohamed Haddad, Danielle Laurin, Charles Ramassamy. DOI 10.1002/alz.051972

    Apolipoprotein E4–driven effects on inflammatory and neurotrophic factors in peripheral extracellular vesicles from cognitively impaired, no dementia participants who converted to Alzheimer's disease Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2021/01. Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy. DOI 10.1002/trc2.12124

    Health Impacts and Characteristics of Deprescribing Interventions in Older Adults: Protocol for a Systematic Review and Meta-analysis (Preprint) 2020/10/21. Zoë Tremblay, David Mumbere, Danielle Laurin, Caroline Sirois, Daniela Furrer, Lise Poisblaud, Pierre-Hugues Carmichael, Barbara Farrell, André Tourigny, Anik Giguere, Isabelle Vedel, José Morais, Edeltraut Kröger. DOI 10.2196/preprints.25200

    The Association Between Dietary Pattern Adherence, Cognitive Stimulating Lifestyle, and Cognitive Function Among Older Adults From the Quebec Longitudinal Study on Nutrition and Successful Aging The Journals of Gerontology: Series B, 2020/10. Matthew D Parrott, Pierre-Hugues Carmichael, Danielle Laurin, Carol E Greenwood, Nicole D Anderson, Guylaine Ferland, Pierrette Gaudreau, Sylvie Belleville, José A Morais, Marie-Jeanne Kergoat, Alexandra J Fiocco. DOI 10.1093/geronb/gbaa178

    Psychosocial Stressors at Work and the Risk of Sickness Absence Due to a Diagnosed Mental Disorder JAMA Psychiatry, 2020/08/01. Caroline S. Duchaine, Karine Aubé, Mahée Gilbert-Ouimet, Michel Vézina, Ruth Ndjaboué, Victoria Massamba, Denis Talbot, Mathilde Lavigne-Robichaud, Xavier Trudel, Ana-Paula Bruno Pena-Gralle, Alain Lesage, Lynne Moore, Alain Milot, Danielle Laurin, Chantal Brisson. DOI 10.1001/jamapsychiatry.2020.0322

    Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study Nutrition Journal, 2020/06. Danielle D’Amico, Matthew D. Parrott, Carol E. Greenwood, Guylaine Ferland, Pierrette Gaudreau, Sylvie Belleville, Danielle Laurin, Nicole D. Anderson, Marie-Jeanne Kergoat, Jose A. Morais, Nancy Presse, Alexandra J. Fiocco. DOI 10.1186/s12937-020-00575-3

    Is Benzodiazepine Use Associated With the Risk of Dementia and Cognitive Impairment–Not Dementia in Older Persons? The Canadian Study of Health and Aging Annals of Pharmacotherapy, 2020/03/09. Mohamed Nafti, Caroline Sirois, Edeltraut Kröger, Pierre-Hugues Carmichael, Danielle Laurin. DOI 10.1177/1060028019882037

    Vitamin D status, cognitive decline and incident dementia: the Canadian Study of Health and Aging Canadian Journal of Public Health, 2020/02/03. Caroline S. Duchaine, Denis Talbot, Mohamed Nafti, Yves Giguère, Sylvie Dodin, André Tourigny, Pierre-Hugues Carmichael, Danielle Laurin. DOI 10.17269/s41997-019-00290-5

    Does serum vitamin D concentration modify the association between arthritis and cardiovascular diseases in both sexes? Rheumatology and Orthopedic Medicine, 2020. Rachelle Saade, Danielle Laurin, Clermont E. Dionne. DOI 10.15761/rom.1000181

    Circulating extracellular vesicles as an emerging tool for the early detection of Alzheimer’s disease or other dementia Alzheimer's & Dementia, 2020. Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy. DOI 10.1002/alz.044074

    Effect of psychosocial work factors on the risk of depression: a protocol of a systematic review and meta-analysis of prospective studies BMJ Open, 2019/11/04. Caroline S Duchaine, Karine Aubé, Mahee Gilbert-Ouimet, Ana Paula Bruno Pena Gralle, Michel Vezina, Ruth Ndjaboue, Victoria K Massamba, Xavier Trudel, Alain Lesage, Lynne Moore, Danielle Laurin, Chantal Brisson. DOI 10.1136/bmjopen-2019-033093

    Development and validation of a Brief Diet Quality Assessment Tool in the French-speaking adults from Quebec International Journal of Behavioral Nutrition and Physical Activity, 2019/08/06. J. Lafrenière, S. Harrison, D. Laurin, C. Brisson, D. Talbot, P. Couture, S. Lemieux, B. Lamarche. DOI 10.1186/s12966-019-0821-6

    Nutrient Patterns, Cognitive Function, and Decline in Older Persons: Results from the Three-City and NuAge Studies Nutrients, 2019/08/05. Benjamin Allès, Cécilia Samieri, Marthe-Aline Jutand, Pierre-Hugues Carmichael, Bryna Shatenstein, Pierrette Gaudreau, Guylaine Ferland, Pascale Barberger-Gateau, Danielle Laurin. DOI 10.3390/nu11081808

    A systematic review of existing peripheral biomarkers of cognitive aging: Is there enough evidence for biomarker proxies in behavioral modification interventions? Ageing Research Reviews, 2019/07. Alexandra J. Fiocco, Laura Krieger, Danielle D’Amico, Matthew D. Parrott, Danielle Laurin, Pierrette Gaudreau, Carol Greenwood, Guylaine Ferland. DOI 10.1016/j.arr.2019.04.008

    Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging Environmental Health, 2019/06. Thierry Comlan Marc Medehouenou, Pierre Ayotte, Pierre-Hugues Carmichael, Edeltraut Kröger, René Verreault, Joan Lindsay, Éric Dewailly, Suzanne L. Tyas, Alexandre Bureau, Danielle Laurin. DOI 10.1186/s12940-019-0494-2

    Domaines de recherche

    • Épidémiologie (sauf l'épidémiologie nutritionnelle et vétérinaire)
    • Épidémiologie nutritionnelle
    • Déterminants biologiques et sociaux du vieillissement
    • Santé publique et santé des populations, n.c.a.
    • Pharmacologie translationnelle et clinique, et thérapeutique

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