Répertoire du corps professoral

Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au 31 mars 2028

Physiological regulation of tau protein
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au 31 mars 2028

Financements des 2 dernières années

Prize - Mid Career Investigator Prize in Research in Aging: Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2023 au 29 février 2024

Mechanisms of neuronal and vascular impairments in ischemic retinopathies
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2019 au 31 mars 2024

Untangling tau contribution to cognitive impairments in Huntington’s disease.
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2019 au 31 mars 2024

Encadrements terminés dans les 5 dernières années

Parissa Fereydouni-Forouzandeh, Maîtrise en neurosciences - avec mémoire

Julius Baya Mdzomba, Doctorat en neurobiologie

Isabelle Guisle, Doctorat en neurobiologie

Publications des 5 dernières années

Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington's Disease Brain. Neuroscience, 2022/07/19. Petry S, Nateghi B, Keraudren R, Sergeant N, Planel E, Hébert SS, St-Amour I. DOI 10.1016/j.neuroscience.2022.07.014

Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer's Disease. Antioxidants (Basel, Switzerland), 2022/04/25. Zussy C, John R, Urgin T, Otaegui L, Claire VIGOR, Acar N, Geoffrey CANET, Vitalis M, Morin F, Planel E, OGER Camille, Durand T, Rajshree SL, Laurent Givalois, Devarajan PV, Desrumaux C. DOI 10.3390/antiox11050838

Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways. Epilepsia, 2022/02/28. Geoffrey CANET, Zub E, Zussy C, Hernandez C, Blaquiere M, Garcia V, Vitalis M, deBock F, Moreno-Montano M, Audinat E, Desrumaux C, Planel E, Laurent Givalois, Nicola Marchi. DOI 10.1111/epi.17186

Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia. Neurobiology of aging, 2022/02/26. Isabelle GUISLE, Geoffrey CANET, Pétry S, Fereydouni-Forouzandeh P, Françoise Morin, Kérauden R, Whittington RA, Frédéric Calon, Hébert SS, Planel E. DOI 10.1016/j.neurobiolaging.2022.02.011

Passive immunization against phosphorylated tau improves features of Huntington's disease pathology. Molecular therapy : the journal of the American Society of Gene Therapy, 2022/01/17. Melanie Alpaugh, Masnata M, Aurelie de Rus Jacquet, Eva LEPINAY, Denis HL, Saint-Pierre M, Davies P, Planel E, Francesca Cicchetti. DOI 10.1016/j.ymthe.2022.01.020

Metabolic determinants of Alzheimer's disease: A focus on thermoregulation. Ageing research reviews, 2021/09. Tournissac M, Leclerc M, Valentin-Escalera J, Vandal M, Bosoi CR, Planel E, Calon F. DOI 10.1016/j.arr.2021.101462

Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimer's research & therapy, 2021/05. Tournissac M, Vu TM, Vrabic N, Hozer C, Tremblay C, Mélançon K, Planel E, Pifferi F, Calon F. DOI 10.1186/s13195-021-00842-3

Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212. Frontiers in neurology, 2020/09. Boscher E, Hernandez-Rapp J, Petry S, Keraudren R, Rainone S, Loiselle A, Goupil C, Turgeon A, St-Amour I, Planel E, Hébert SS. DOI 10.3389/fneur.2020.578720

Repurposing beta3-adrenergic receptor agonists for Alzheimer’s disease: Beneficial effects on recognition memory and amyloid pathology in a mouse model 2020/05. Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, Planel E, Pifferi F, Calon F. DOI 10.1101/2020.05.25.114454

Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature. Sleep, 2020/04. Guisle I, Gratuze M, Petry S, Morin F, Keraudren R, Whittington RA, Hébert SS, Mongrain V, Planel E. DOI 10.1093/sleep/zsz266

MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice. Frontiers in neuroscience, 2020/01. Boscher E, Goupil C, Petry S, Keraudren R, Loiselle A, Planel E, Hébert SS. DOI 10.3389/fnins.2020.591138

Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits. Journal of the American Heart Association, 2019/05. Muhire G, Iulita MF, Vallerand D, Youwakim J, Gratuze M, Petry FR, Planel E, Ferland G, Girouard H. DOI 10.1161/jaha.118.011630

The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice. Brain research, 2019/01. Gratuze M, Josset N, Petry FR, Pflieger M, Eyoum Jong L, Truchetti G, Poitras I, Julien J, Bezeau F, Morin F, Samadi P, Cicchetti F, Bretzner F, Planel E. DOI 10.1016/j.brainres.2019.01.016

Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation. Molecular metabolism, 2019/01. Tournissac M, Bourassa P, Martinez-Cano RD, Vu TM, Hébert SS, Planel E, Calon F. DOI 10.1016/j.molmet.2019.01.008