Répertoire du corps professoral

Creating a biomimetic 3D engineered model of the liver metastatic niche
Programme: Fonds Nouvelles frontières en recherche - Volet Exploration
Organisme(s) subventionnaire(s): Secrétariat des programmes interorganismes à l’intention des établissements
Type de financement: Subvention
Établissement tête: Université Laval
Du 31 mars 2024 au 30 mars 2026

Mise en place de la plateforme d'ingénierie tissulaire en cancer
Programme: Fonds d'innovation (FI)
Organisme(s) subventionnaire(s): Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux, Advanced Solutions
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2023 au 31 décembre 2025

Protein glycation acts as a substrate-dependent tumorigenic molecular switch in prostate cancer
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Institut de recherche du Centre universitaire de santé McGill
Du 1 avril 2022 au 31 mars 2027

Canada Research Chair in Tumor Mechanoregulation
Programme: Chaires de recherche du Canada - Fonctionnement
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2020 au 30 juin 2025

The combined role of cellular force dynamics and extracellular matrix mechanical properties in driving angiogenesis
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2018 au 31 mars 2025

Financements des 2 dernières années

Hepatic stellate cells as a driver of the pre-metastatic niche in uveal melanoma
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2023 au 29 février 2024

Programme de soutien aux nouveaux détenteurs de CRC
Programme: Fonds de soutien aux professeurs-chercheurs bénéficiant d’une Chaire de recherche du Canada
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mai 2022 au 30 avril 2024

Exploration of a novel therapeutic strategy impeding triple-negative breast cancer growth and progression
Organisme(s) subventionnaire(s): Fondation de l'Université Laval
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022 au 31 mars 2023

Toward elucidating the interplay between cell contractility state, mechanotransduction and alternative splicing during tumor progression
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2022 au 28 février 2023

Thérapie photodynamique véctorisée du cancer de la vessie: étude sur un modèle 3D reconstruit par génie tissulaire
Programme: Programme Samuel-De Champlain
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2021 au 31 mars 2023

Seyed Mohammad Reza Rafieipour Alavi, Stage postdoctoral en médecine

Encadrements terminés dans les 5 dernières années

Enola Bollmann, Maîtrise en biologie cellulaire et moléculaire - avec mémoire

Kevin Homsy, Maîtrise en biologie cellulaire et moléculaire - avec mémoire

Nafiseh Sadat Mousavi Maleki, Maîtrise en biologie cellulaire et moléculaire - avec mémoire

Publications des 5 dernières années

Tension directs cancer cell migration over fiber alignment through energy minimization Biomaterials, 2024/12. Matthew R. Zanotelli, Joseph P. Miller, Wenjun Wang, Ismael Ortiz, Elise Tahon, Francois Bordeleau, Cynthia A. Reinhart-King. DOI 10.1016/j.biomaterials.2024.122682

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression 2024/04/14. Diogjena Katerina Prifti, Eva Calvo, Annie Lauzier, Chantal Garand, Romain Devillers, Suparba Roy, Alexsandro Dos Santos, Laurence Descombes, François Bordeleau, Sabine Elowe. DOI 10.1101/2024.04.14.589449

Using Machine Learning to Predict TP53 Mutation Status and Aggressiveness of Prostate Cancer from Routine Histology Images Cancer Research, 2023/09/01. François Bordeleau. DOI 10.1158/0008-5472.CAN-23-1856

Substrate stiffness regulates focal adhesion kinase alternative splicing in breast cancer Biophysical journal, 2023. Millet, M., Pic, E., Luthold, C., Bourriquen, G., Khelifi, G., Hussein, S., Bordeleau, F.. DOI 10.1016/j.bpj.2022.11.1533

Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA Cell Reports, 2023. Wang, W., Taufalele, P.V., Millet, M., Homsy, K., Smart, K., Berestesky, E.D., Schunk, C.T., Rowe, M.M., Bordeleau, F., Reinhart-King, C.A.. DOI 10.1016/j.celrep.2023.112338

Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment Acta Biomaterialia, 2023. Taufalele, P.V., Wang, W., Simmons, A.J., Southard-Smith, A.N., Chen, B., Greenlee, J.D., King, M.R., Lau, K.S., Hassane, D.C., Bordeleau, F., Reinhart-King, C.A.. DOI 10.1016/j.actbio.2022.04.031

Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis Cell Reports, 2023. Tang, Y.C., Ponsin, K., Graham-Paquin, A.-L., Luthold, C., Homsy, K., Schindler, M., Tran, V., Côté, J.-F., Bordeleau, F., Khadra, A., Bouchard, M.. DOI 10.1016/j.celrep.2023.112202

Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment Cells, 2022/11/29. Léo Piquet, Kelly Coutant, Andrew Mitchell, Amel Ben Anes, Enola Bollmann, Nathan Schoonjans, Julie Bérubé, François Bordeleau, Alain Brisson, Solange Landreville. DOI 10.3390/cells11233828

Cancer-Associated Fibroblasts in a 3D Engineered Tissue Model Induce Tumor-like Matrix Stiffening and EMT Transition Cancers, 2022/08/05. Martial Millet, Enola Bollmann, Cassandra Ringuette Goulet, Geneviève Bernard, Stéphane Chabaud, Marc-Étienne Huot, Frédéric Pouliot, Stéphane Bolduc, François Bordeleau. DOI 10.3390/cancers14153810

The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance? Cancers, 2022/06/11. Carole Luthold, Tarek Hallal, David P. Labbé, François Bordeleau. DOI 10.3390/cancers14122887

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis eLife, 2022. Schwager, S.C., Young, K.M., Hapach, L.A., Carlson, C.M., Mosier, J.A., McArdle, T.J., Wang, W., Schunk, C., Jayathilake, A.L., Bates, M.E., Bordeleau, F., Antonyak, M.A., Cerione, R.A., Reinhart-King, C.A.. DOI 10.7554/ELIFE.74433

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis 2021/10/29. Samantha C. Schwager, Lauren A. Hapach, Caroline M. Carlson, Jenna A. Mosier, Tanner J. McArdle, Wenjun Wang, Anissa L. Jayathilake, Francois Bordeleau, Marc A. Antonyak, Richard A. Cerione, Cynthia A. Reinhart-King. DOI 10.1101/2021.10.27.466095

Phenotypic heterogeneity and metastasis of breast cancer cells Cancer Research, 2021. Hapach, L.A., Carey, S.P., Schwager, S.C., Taufalele, P.V., Wang, W., Mosier, J.A., Ortiz-Otero, N., McArdle, T.J., Goldblatt, Z.E., Lampi, M.C., Bordeleau, F., Marshall, J.R., Richardson, I.M., Li, J., King, M.R., Reinhart-King, C.A.. DOI 10.1158/0008-5472.CAN-20-1799

Chaperone-Assisted Mitotic Actin Remodeling by BAG3 and HSPB8 Involves the Deacetylase HDAC6 and Its Substrate Cortactin International Journal of Molecular Sciences, 2020/12/25. Carole Luthold, Alice-Anaïs Varlet, Herman Lambert, François Bordeleau, Josée N. Lavoie. DOI 10.3390/ijms22010142

High type I collagen density fails to increase breast cancer stem cell phenotype PeerJ, 2020/05/12. Iuri C. Valadão, Ana Carolina L. Ralph, François Bordeleau, Luciana M. Dzik, Karen S.C. Borbely, Murilo V. Geraldo, Cynthia A. Reinhart-King, Vanessa M. Freitas. DOI 10.7717/peerj.9153

Adenoviral protein E4orf4 interacts with the polarity protein par3 to induce nuclear rupture and tumor cell death Journal of Cell Biology, 2020. Dziengelewski, C., Rodrigue, M.-A., Caillier, A., Jacquet, K., Boulanger, M.-C., Bergeman, J., Fuchs, M., Lambert, H., Laprise, P., Richard, D.E., Bordeleau, F., Huot, M.-É., Lavoie, J.N.. DOI 10.1083/JCB.201805122

Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility Journal of Cell Science, 2020/01/01. Francois Bordeleau, Wenjun Wang, Alysha Simmons, Marc A. Antonyak, Richard A. Cerione, Cynthia A. Reinhart-King. DOI 10.1242/jcs.231134

Author Correction: Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making Nature Communications, 2019/12/04. Matthew R. Zanotelli, Aniqua Rahman-Zaman, Jacob A. VanderBurgh, Paul V. Taufalele, Aadhar Jain, David Erickson, Francois Bordeleau, Cynthia A. Reinhart-King. DOI 10.1038/s41467-019-13655-8

Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains Biophysical Journal, 2019/11. Jenna A. Mosier, Aniqua Rahman-Zaman, Matthew R. Zanotelli, Jacob A. VanderBurgh, Francois Bordeleau, Brenton D. Hoffman, Cynthia A. Reinhart-King. DOI 10.1016/j.bpj.2019.09.024

Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making Nature Communications, 2019/09/13. Matthew R. Zanotelli, Aniqua Rahman-Zaman, Jacob A. VanderBurgh, Paul V. Taufalele, Aadhar Jain, David Erickson, Francois Bordeleau, Cynthia A. Reinhart-King. DOI 10.1038/s41467-019-12155-z

Synergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth Cancers, 2019/07/24. Léo Piquet, Louise Dewit, Nathan Schoonjans, Martial Millet, Julie Bérubé, Peter R. A. Gerges, François Bordeleau, Solange Landreville. DOI 10.3390/cancers11081043

Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology Micromachines, 2019/06/22. Martial Millet, Raoua Ben Messaoud, Carole Luthold, Francois Bordeleau. DOI 10.3390/mi10060418

Matrix stiffness regulates vascular integrity through focal adhesion kinase activity FASEB Journal, 2019. Wang, W., Lollis, E.M., Bordeleau, F., Reinhart-King, C.A.. DOI 10.1096/fj.201800841R

Matrix stiffness regulates microvesicle-induced fibroblast activation American Journal of Physiology - Cell Physiology, 2019. Schwager, S.C., Bordeleau, F., Zhang, J., Antonyak, M.A., Cerione, R.A., Reinhart-King, C.A.. DOI 10.1152/ajpcell.00418.2018

Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells Proceedings of the National Academy of Sciences of the United States of America, 2019. Zhang, J., Goliwas, K.F., Wang, W., Taufalele, P.V., Bordeleau, F., Reinhart-King, C.A.. DOI 10.1073/pnas.1809964116