Répertoire du corps professoral

Réseau Québécois en Reproduction
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 avril 2024 au 31 mars 2030

Defining the role of GATA4 in steroidogenic cells and sex differentiation in males using novel mouse models
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au 31 mars 2028

Probing the origins and crosstalk between the different Leydig cell populations in the mammalian gonad
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022 au 31 mars 2027

Réseau Québécois en Reproduction (RQR)
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies, Université de Sherbrooke, Université Laval - Fonds internes, Université de Montréal, Université du Québec à Trois-Rivières, Institut national de recherche scientifique (INRS)
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 avril 2017 au 31 mars 2025

Financements des 2 dernières années

Rôle du facteur de transcription GATA4 dans la différenciation sexuelle masculine
Programme: BDR - Contributions
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2022 au 30 juin 2023

Encadrements terminés dans les 5 dernières années

Zoheir Benaoumer Demmouche, Doctorat en médecine moléculaire

Oona Delmas, Maîtrise en médecine moléculaire - avec mémoire

Shirley Ferrier Tarin, Maîtrise en médecine moléculaire - avec mémoire

Karine De Mattos, Doctorat en médecine moléculaire

Samir Mehanovic, Doctorat en médecine moléculaire

Publications des 5 dernières années

A STAR for the ages: a 30-year historical perspective of the role of transcription factors in the regulation of steroidogenic acute regulatory gene expression Journal of Endocrinology, 2024/08/29. Robert S Viger, Marie France Bouchard, Jacques J Tremblay. DOI 10.1530/JOE-24-0087

Hormones and Signaling Pathways Involved in the Stimulation of Leydig Cell Steroidogenesis Endocrines, 2023/08/01. Karine de Mattos, Kenley Joule Pierre, Jacques J. Tremblay. DOI 10.3390/endocrines4030041

ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells Endocrinology, 2023/08/01. Karine de Mattos, Félix-Olivier Dumas, Gabriel Henrique Campolina-Silva, Clémence Belleannée, Robert S Viger, Jacques J Tremblay. DOI 10.1210/endocr/bqad120

A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells International Journal of Molecular Sciences, 2022/12/01. Xavier C. Giner, Kenley Joule Pierre, Nicholas M. Robert, Jacques J. Tremblay. DOI 10.3390/ijms232315060

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells International Journal of Molecular Sciences, 2022/10/29. Kenley Joule Pierre, Jacques J. Tremblay. DOI 10.3390/ijms232113153

Comprehensive and Quantitative Analysis of the Changes in Proteomic and Phosphoproteomic Profiles during Stimulation and Repression of Steroidogenesis in MA-10 Leydig Cells International Journal of Molecular Sciences, 2022/10/25. Zoheir B. Demmouche, Jacques J. Tremblay. DOI 10.3390/ijms232112846

A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis International Journal of Molecular Sciences, 2022/10/09. Marie France Bouchard, Julia Picard, Jacques J. Tremblay, Robert S. Viger. DOI 10.3390/ijms231912009

Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti‐Müllerian hormone receptor type 2 transcription in mouse MA‐10 Leydig cells Andrology, 2022/10. Samir Mehanovic, Kenley Joule Pierre, Robert S. Viger, Jacques J. Tremblay. DOI 10.1111/andr.13266

The Urokinase-Type Plasminogen Activator Contributes to cAMP-Induced Steroidogenesis in MA-10 Leydig Cells Endocrines, 2022/07/28. Zoheir B. Demmouche, Jacques J. Tremblay. DOI 10.3390/endocrines3030037

The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells. Reproduction (Cambridge, England), 2022/06/27. Di-Luoffo M, Pierre KJ, Robert NM, Girard MJ, Jacques J. Tremblay. DOI 10.1530/rep-22-0109

Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression. Frontiers in endocrinology, 2022/05/26. Viger RS, de Mattos K, Jacques J. Tremblay. DOI 10.3389/fendo.2022.902198

Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function. Frontiers in endocrinology, 2022/04/07. de Mattos K, Viger RS, Jacques J. Tremblay. DOI 10.3389/fendo.2022.881309

Mechanism of Action of an Environmentally Relevant Organochlorine Mixture in Repressing Steroid Hormone Biosynthesis in Leydig Cells International Journal of Molecular Sciences, 2022/04. annick niquaise enangue njembele, Zoheir B. Demmouche, Janice Bailey, Jacques J. Tremblay. DOI 10.3390/ijms23073997

Growth Hormone-induced STAT5B Regulates Star Gene Expression Through a Cooperation With cJUN in Mouse MA-10 Leydig Cells Endocrinology, 2022/02/01. Pierre-Olivier Hébert-Mercier, Francis Bergeron, Nicholas M Robert, Samir Mehanovic, Kenley Joule Pierre, Raifish E Mendoza-Villarroel, Karine de Mattos, Catherine Brousseau, Jacques J Tremblay. DOI 10.1210/endocr/bqab267

Dynamic Expression of the Homeobox Factor PBX1 during Mouse Testis Development Endocrines, 2022/01/05. Vanessa Moisan, Catherine Brousseau, Jacques J. Tremblay. DOI 10.3390/endocrines3010002

Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†. Biology of reproduction, 2021/11/01. Mehanovic S, Mendoza-Villarroel RE, de Mattos K, Talbot P, Viger RS, Jacques J. Tremblay. DOI 10.1093/biolre/ioab131

Mechanisms of MEHP Inhibitory Action and Analysis of Potential Replacement Plasticizers on Leydig Cell Steroidogenesis International Journal of Molecular Sciences, 2021/10/24. Annick N. Enangue Njembele, Jacques J. Tremblay. DOI 10.3390/ijms222111456

The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells Journal of the Endocrine Society, 2019/12/01. Samir Mehanovic, Raifish E Mendoza-Villarroel, Robert S Viger, Jacques J Tremblay. DOI 10.1210/js.2019-00266

Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse Andrology, 2019. Bergeron, F., Sab, A. Boulende, Bouchard, M. F., Taniguchi, H., Souchkova, O., Brousseau, C., Tremblay, J. J., Pilon, N., Viger, R. S.. DOI 10.1111/ANDR.12601