Répertoire du corps professoral

Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université du Québec à Montréal - UQAM
Du 1 avril 2024 au 31 mars 2030

Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au 31 mars 2028

A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2021 au 30 septembre 2026

Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease
Programme: Subvention en aide à la recherche
Organisme(s) subventionnaire(s): Crohn et Colite Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2021 au 30 juin 2025

Financements des 2 dernières années

Scaling up the production of recombinant human NTPDase8 in CHO expression system for in vivo testing
Programme: Projet subsidiaire d'un regroupement stratégique
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université du Québec à Montréal - UQAM
Du 1 septembre 2023 au 31 mars 2024

A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2018 au 31 mars 2023

Encadrements terminés dans les 5 dernières années

Chakib Hamoudi, Maîtrise en microbiologie-immunologie - avec mémoire

Romuald Brice Babou Kammoe, Maîtrise en biologie cellulaire et moléculaire - avec mémoire

Publications des 5 dernières années

CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets Frontiers in Immunology, 2024/06/28. Xiangni Wu, Pin-I Chen, Robert L. Whitener, Matthew S. MacDougall, Vy M. N. Coykendall, Hao Yan, Yong Bin Kim, William Harper, Shiva Pathak, Bettina P. Iliopoulou, Allison Hestor, Diane C. Saunders, Erick Spears, Jean Sévigny, David M. Maahs, Marina Basina, Seth A. Sharp, Anna L. Gloyn, Alvin C. Powers, Seung K. Kim, Kent P. Jensen, Everett H. Meyer. DOI 10.3389/fimmu.2024.1415102

Endometrial epithelial cell organoids as tools for studying the CD39 family of enzymes and for validating enzyme inhibitors. Histology and histopathology, 2024/06/17. Rodríguez-Martínez A, Torrejón-Escribano B, Eritja N, Dorca-Arévalo J, Gabaldón C, Sévigny J, Matias-Guiu X, Martín-Satué M. DOI 10.14670/hh-18-782

Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors. International journal of biological macromolecules, 2024/03/24. Tasleem M, Pelletier J, Sévigny J, Hussain Z, Ajmal M, Al-Harrasi A, El-Kott AF, Taslimi P, Negm S, Shafiq Z, Iqbal J. DOI 10.1016/j.ijbiomac.2024.131068

Extracellular nucleotides in smooth muscle contraction Biochemical Pharmacology, 2024/02. Romuald Brice Babou Kammoe, Jean Sévigny. DOI 10.1016/j.bcp.2023.116005

Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitors Results in Chemistry, 2024/01. Abdullah Yahya Abdullah Alzahrani, Abdul Hameed, Abdul Rehman Khan, Julie Pelletier, Jean Sévigny, Jamshed Iqbal. DOI 10.1016/j.rechem.2024.101548

Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme. Purinergic signalling, 2023/10/31. da Silva ÁC, Scholl JN, de Fraga Dias A, Weber AF, Morrone FB, Cruz-López O, Conejo-García A, Campos JM, Sévigny J, Figueiró F, Battastini AMO. DOI 10.1007/s11302-023-09975-6

NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow International Journal of Molecular Sciences, 2023/10/10. Julie Favre, Charlotte Roy, Anne-Laure Guihot, Annick Drouin, Manon Laprise, Marc-Antoine Gillis, Simon C. Robson, Eric Thorin, Jean Sévigny, Daniel Henrion, Gilles Kauffenstein. DOI 10.3390/ijms242015038

UTP increases wound healing in the self assembled skin substitute (SASS) Journal of Cell Communication and Signaling, 2023/09. Liliana I. Sous Naasani, Jean Sévigny, Véronique J. Moulin, Marcia Wink. DOI 10.1007/s12079-023-00725-2

Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) – a promising target for the immunotherapy of cancer Frontiers in Immunology, 2023/08/29. Vittoria Lopez, H. J. Maximilian Schuh, Salahuddin Mirza, Victoria J. Vaaßen, Michael S. Schmidt, Katharina Sylvester, Riham M. Idris, Christian Renn, Laura Schäkel, Julie Pelletier, Jean Sévigny, Annamaria Naggi, Björn Scheffler, Sang-Yong Lee, Gerd Bendas, Christa E. Müller. DOI 10.3389/fimmu.2023.1173634

Resistance training reduces platelet activation in hypertensive women: the role of purinergic signaling Journal of Hypertension, 2023/08/10. Andréia Machado Cardoso, Nyasmin Mendes Aneli, Mônica Lammers, Aline Mânica, Daniela Zanini, Sarah Franco Vieira de Oliveira Maciel, Jean Sévigny, Vanessa da Silva Corralo, Clodoaldo Antônio De Sá. DOI 10.1097/hjh.0000000000003529

Synthesis of Thieno[3,2-d]pyrimidine Derivatives through Sequential SNAr and Suzuki Reactions as Selective h-NTPDases Inhibitors ChemMedChem, 2023/07/17. Gohar Zaman, Saif Ullah, Muhammad Uzair, Sania Batool, Haseen Ahmad, Farman Ullah, Julia Pelletier, Jean Sévigny, Jamshed Iqbal, Abbas Hassan. DOI 10.1002/cmdc.202300165

Synthesis and structure–activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39 Bioorganic Chemistry, 2023/06. Chunyang Bi, Laura Schäkel, Salahuddin Mirza, Katharina Sylvester, Julie Pelletier, Sang-Yong Lee, Thanigaimalai Pillaiyar, Jean Sévigny, Christa E. Müller. DOI 10.1016/j.bioorg.2023.106460

Epidermal melanocytes metabolize extracellular nucleotides by purinergic enzymes Biochemistry and Cell Biology, 2023/06/01. Liliana Sous Naasani, Jéssica Gonçalves Azevedo, Jean Sévigny, Tiago Franco de Oliveira, Silvya Stuchi Maria-Engler, Marcia Wink. DOI 10.1139/bcb-2022-0058

Tumor-neutrophil crosstalk promotes in vitro and in vivo glioblastoma progression Frontiers in Immunology, 2023/05/24. Dominique S. Rubenich, Priscila O. de Souza, Natalia Omizzollo, Mariana R. Aubin, Paulo J. Basso, Luisa M. Silva, Eloisa M. da Silva, Fernanda C. Teixeira, Gabriela F.S. Gentil, Jordana L. Domagalski, Maico T. Cunha, Kerolainy A. Gadelha, Leonardo F. Diel, Nicolly E. Gelsleichter, Aline S. Rubenich, Gabriela S. Lenz, Aline M. de Abreu, Giselle M. Kroeff, Ana H. Paz, Fernanda Visioli, Marcelo L. Lamers, Marcia R. Wink, Paulo V. Worm, Anelise B. Araújo, Jean Sévigny, Niels O. S. Câmara, Nils Ludwig, Elizandra Braganhol. DOI 10.3389/fimmu.2023.1183465

Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX Medicinal Chemistry Research, 2023/05. Saquib Jalil, Saif Ullah, Seyed-Omar Zaraei, Rawan M. Sbenati, Afnan I. Shahin, Bilal O. AlKubaisi, Julie Pelletier, Jean Sévigny, Taleb H. Al-Tel, Jamshed Iqbal, Mohammed El-Gamal. DOI 10.1007/s00044-023-03043-9

Stomach-derived human insulin-secreting organoids restore glucose homeostasis Nature Cell Biology, 2023/05. Xiaofeng Huang, Wei Gu, Jiaoyue Zhang, Ying Lan, Jonathan L. Colarusso, Sanlan Li, Christoph Pertl, Jiaqi Lu, Hyunkee Kim, Jian Zhu, David T. Breault, Jean Sévigny, Qiao Zhou. DOI 10.1038/s41556-023-01130-y

Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: Synthesis, biological evaluation and in silico study Bioorganic Chemistry, 2023/05. Hafiza Amna Younus, Muhammad Saeed, Abid Mahmood, Muhammad Siraj Khan Jadoon, Abdul Hameed, Asnuzilawati Asari, Habsah Mohamad, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Mariya al-Rashida. DOI 10.1016/j.bioorg.2023.106450

Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors Stem Cell Research & Therapy, 2023/04/19. José Bernardo Noronha-Matos, Rui Pinto-Cardoso, Catarina Bessa-Andrês, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Maria Adelina Costa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá. DOI 10.1186/s13287-023-03315-6

Synthesis of new sulphonate derivatives containing adamantane and 4-chlorophenyl moieties as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors Journal of Molecular Structure, 2023/02. Saif Ullah, Kiran Hamid, Amna Batool, Julie Pelletier, Jean Sévigny, Abdul Rehman Khan, Peter Langer, Jamshed Iqbal. DOI 10.1016/j.molstruc.2022.134494

Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors RSC Advances, 2023. Muhammad Siraj Khan Jadoon, Julie Pelletier, Jean Sévigny, Jamshed Iqbal. DOI 10.1039/D3RA04266A

Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for h-NTPDases RSC Advances, 2023. Zahid Hussain Zaigham, Saif Ullah, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Abbas Hassan. DOI 10.1039/D3RA03874B

Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages Acta Tropica, 2023/01. Walmir da Silva, Isadora Cunha Ribeiro, Joice de Melo Agripino, Victor Hugo Ferraz da Silva, Luciana Ângelo de Souza, Tatiana Aparecida Oliveira, Gustavo Costa Bressan, Raphael de Souza Vasconcellos, Carole Dumas, Julie Pelletier, Jean Sévigny, Barbara Papadopoulou, Juliana Lopes Rangel Fietto. DOI 10.1016/j.actatropica.2022.106732

Bioscaffold developed with decellularized human amniotic membrane seeded with mesenchymal stromal cells: assessment of efficacy and safety profiles in a second-degree burn preclinical model Biofabrication, 2023/01/01. Liliana Ivet Sous Naasani, Luiza Pretto, Carla Zanatelli, Thaís Casagrande Paim, Aline Francielle Damo Souza, Pablo Fagundes Pase, Marilda Da Cruz Fernandes, Jean Sévigny, Marcia Wink. DOI 10.1088/1758-5090/ac9ff4

Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases Bioorganic Chemistry, 2022/12. Zahra Begum, Saif Ullah, Muhammad Akram, Muhammad Uzair, Farman Ullah, Ahsanullah, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Abbas Hassan. DOI 10.1016/j.bioorg.2022.106196

Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European journal of medicinal chemistry, 2022/11/26. Shahin AI, Zaraei SO, AlKubaisi BO, Ullah S, Hanan S. Anbar, El-Gamal R, Menon V, Abdel-Maksoud MS, Oh CH, El-Awady R, Gelsleichter NE, Pelletier J, Sévigny J, Iqbal J, Al-Tel TH, El-Gamal MI. DOI 10.1016/j.ejmech.2022.114958

Diacylhydrazine Derivatives of 2-(5-(Pyridin-3-yl)-2H-Tetrazol-2-yl)Acetohydrazide and 2-(5-(Pyridin-4-yl)-2H-Tetrazol-2-yl)Acetohydrazide as Potential Inhibitors of Nucleotide Pyrophosphatase Russian Journal of Bioorganic Chemistry, 2022/10. M. Arif, G. Shabir, S. A. Ejaz, A. Saeed, S. U. Khan, J. Lecka, J. Sévigny, J. Iqbal. DOI 10.1134/s1068162022050053

The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis Journal of immunology (Baltimore, Md : 1950), 2022. Hamoudi, C, Zhao, C, Abderrazak, A, Salem, M, Fortin, PR, Sévigny, J, Aoudjit, F. DOI 10.4049/jimmunol.2100550

Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors Bioorganic chemistry, 2022. Abbas, S, Afzal, S, Nadeem, H, Hussain, D, Langer, P, Sévigny, J, Ashraf, Z, Iqbal, J. DOI 10.1016/j.bioorg.2021.105456

Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists Bioorganic & medicinal chemistry letters, 2022. Jung, Y. H., Shah, Q., Lewicki, S. A., Pramanik, A., Gopinatth, V., Pelletier, J., Sévigny, J., Iqbal, J., Jacobson, K. A.. DOI 10.1016/j.bmcl.2022.128981

Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors ACS omega, 2022. Ullah, S, Pelletier, J, Sévigny, J, Iqbal, J. DOI 10.1021/acsomega.2c03473

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapy Journal for immunotherapy of cancer, 2022. Schäkel, L, Mirza, S, Winzer, R, Lopez, V, Idris, R, Al-Hroub, H, Pelletier, J, Sévigny, J, Tolosa, E, Müller, CE. DOI 10.1136/jitc-2022-004660

NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD Gut, 2022. Salem, M, Lecka, J, Pelletier, J, Gomes Marconato, D, Dumas, A, Vallières, L, Brochu, G, Robaye, B, Jobin, C, Sévigny, J. DOI 10.1136/gutjnl-2020-320937

Homeostasis of extracellular ATP in uninfected RBCs from a Plasmodium falciparum culture and derived microparticles Biochimica et biophysica acta Biomembranes, 2022. Alvarez, CL, Chêne, A, Semblat, JP, Gamain, B, Lapouméroulie, C, Fader, CM, Hattab, C, Sévigny, J, Denis, MFL, Lauri, N, Ostuni, MA, Schwarzbaum, PJ. DOI 10.1016/j.bbamem.2022.183980

HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES 2022. Jean Sévigny, Fischer Hana, Bilha, Nassir, Molhm, Zelikman, Vadim, Arad Uri, Moshe, Muller, Christa.

2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors Archiv der Pharmazie, 2021/12. Laura Schäkel, Salahuddin Mirza, Markus Pietsch, Sang‐Yong Lee, Tim Keuler, Katharina Sylvester, Julie Pelletier, Jean Sévigny, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Michael Gütschow, Christa E. Müller. DOI 10.1002/ardp.202100300

New insights into cytotoxic mechanisms of bozepinib against glioblastoma European Journal of Pharmaceutical Sciences, 2021/07. Amanda de Fraga Dias, Juliete Nathali Scholl, Cesar Eduardo Jacintho Moritz, Luciano Porto Kagami, Gustavo Machado das Neves, Vera Lúcia Eifler-Lima, Olga Cruz-López, Ana Conejo-García, Jean Sévigny, Ana Maria Oliveira Battastini, Joaquin María Campos, Fabrício Figueiró. DOI 10.1016/j.ejps.2021.105823

Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines Journal of biomolecular structure & dynamics, 2021. Aziz, H, Mahmood, A, Zaib, S, Saeed, A, El-Seedi, HR, Pelletier, J, Sévigny, J, Iqbal, J. DOI 10.1080/07391102.2020.1802336

Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents European journal of medicinal chemistry, 2021. Ullah, S, El-Gamal, MI, El-Gamal, R, Pelletier, J, Sevigny, J, Shehata, MK, Anbar, HS, Iqbal, J. DOI 10.1016/j.ejmech.2021.113339

Synthesis, In-vitro evaluation and molecular docking studies of oxoindolin phenylhydrazine carboxamides as potent and selective inhibitors of ectonucleoside triphosphate diphosphohydrolase (NTPDase) Bioorganic chemistry, 2021. Afzal, S, Al-Rashida, M, Hameed, A, Pelletier, J, Sévigny, J, Iqbal, J. DOI 10.1016/j.bioorg.2021.104957

Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39 Marine drugs, 2021. Lopez, V, Schakel, L, Schuh, HJM, Schmidt, MS, Mirza, S, Renn, C, Pelletier, J, Lee, SY, Sevigny, J, Alban, S, Bendas, G, Muller, CE. DOI 10.3390/md19020051

Neutrophils: fast and furious-the nucleotide pathway Purinergic signalling, 2021. Rubenich, DS, de Souza, PO, Omizzollo, N, Lenz, GS, Sevigny, J, Braganhol, E. DOI 10.1007/s11302-021-09786-7

NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female Biomolecules, 2021. Babou Kammoe, RB, Kauffenstein, G, Pelletier, J, Robaye, B, Sevigny, J. DOI 10.3390/biom11020147

Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth Purinergic signalling, 2021. Lopes, DV, de Fraga Dias, A, Silva, LFL, Scholl, JN, Sévigny, J, Battastini, AMO, Figueiró, F. DOI 10.1007/s11302-021-09775-w

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer Medicinal chemistry (Shariqah (United Arab Emirates)), 2021. Iqbal, J, Basharat, A, Bano, S, Abid, SMA, Pelletier, J, Sévigny, J. DOI 10.2174/1573406416666200925141703

Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism Metabolism: clinical and experimental, 2021. S, hu, B, Tran, S, Singhal, G, Syed, I, Feldbrügge, L, Mitsuhashi, S, Pelletier, J, Huang, J, Yalcin, Y, Csizmadia, E, Tiwari-Heckler, S, Enjyoji, K, Sévigny, J, Maratos-Flier, E, Robson, SC, Jiang, ZG, Perez-Matos, MC. DOI 10.1016/j.metabol.2021.154731

Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation Purinergic signalling, 2021. Haas, CB, Lovászi, M, Pacher, P, de Souza, PO, Pelletier, J, Leite, RO, Sévigny, J, Németh, Z, Braganhol, E, Haskó, G. DOI 10.1007/s11302-021-09819-1

Extracellular ATP hydrolysis in Caco-2 human intestinal cell line Biochimica et biophysica acta Biomembranes, 2021. Schachter, J, Alvarez, CL, Bazzi, Z, Faillace, MP, Corradi, G, Hattab, C, Rinaldi, DE, Gonzalez-Lebrero, R, Molineris, MP, Sévigny, J, Ostuni, MA, Schwarzbaum, PJ. DOI 10.1016/j.bbamem.2021.183679

Editorial: Metalloenzymes: Potential Drug Targets Frontiers in pharmacology, 2021. Iqbal, J, Jacob, C, Sévigny, J. DOI 10.3389/fphar.2021.746925

Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor Bioorganic chemistry, 2021. Murtaza, A, Afzal, S, Zaman, G, Saeed, A, Pelletier, J, Sévigny, J, Iqbal, J, Hassan, A. DOI 10.1016/j.bioorg.2021.105240

Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes Journal of personalized medicine, 2021. Rodriguez-Martinez, A, Trapero, C, Vidal, A, Piulats, JM, Gomez de Ar, a, I, Sevigny, J, Fern, ez-Montoli, ME, Ponce, J, Matias-Guiu, X, Martin-Satue, M. DOI 10.3390/jpm11050331

Antenatal Dexamethasone Treatment Induces Sex-dependent Upregulation of NTPDase1/CD39 and Ecto-5'-nucleotidase/CD73 in the Rat Fetal Brain Cellular and molecular neurobiology, 2021. Manojlovic-Stojanoski, M, Lavrnja, I, Stevanovic, I, Trifunovic, S, Ristic, N, Nestorovic, N, Sevigny, J, Nedeljkovic, N, Laketa, D. DOI 10.1007/s10571-021-01081-8

The anti-inflammatory effect of resistance training in hypertensive women: the role of purinergic signaling Journal of hypertension, 2020. Lammers, MD, Aneli, NM, de Oliveira, GG, de Oliveira Maciel, SFV, Zanini, D, Manica, A, de Resende E Silva, DT, Bagatini, MD, Sevigny, J, De Sa, CA, Manfredi, LH, Cardoso, AM. DOI 10.1097/HJH.0000000000002578

Synthesis, characterization, in vitro tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibition studies and computational evaluation of novel thiazole derivatives Bioorganic chemistry, 2020. Aziz, H, Mahmood, A, Zaib, S, Saeed, A, Shafiq, Z, Pelletier, J, Sevigny, J, Iqbal, J. DOI 10.1016/j.bioorg.2020.104088

Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase Bioorganic chemistry, 2020. Ullah, S, El-Gamal, MI, Zaib, S, Anbar, HS, Zaraei, SO, Sbenati, RM, Pelletier, J, Sevigny, J, Oh, CH, Iqbal, J. DOI 10.1016/j.bioorg.2020.103783

Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors ACS medicinal chemistry letters, 2020. Ashraf, A, Shafiq, Z, Khan Jadoon, MS, Tahir, MN, Pelletier, J, Sevigny, J, Yaqub, M, Iqbal, J. DOI 10.1021/acsmedchemlett.0c00343

Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors European journal of medicinal chemistry, 2020. Ahmad, H, Ullah, S, Rahman, F, Saeed, A, Pelletier, J, Sevigny, J, Hassan, A, Iqbal, J. DOI 10.1016/j.ejmech.2020.112759

Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification Bioorganic chemistry, 2020. Andleeb, H, Hussain, M, Abida Ejaz, S, Sevigny, J, Farman, M, Yasinzai, M, Zhang, J, Iqbal, J, Hameed, S. DOI 10.1016/j.bioorg.2020.103999

Synthesis and Nucleotide Pyrophosphatase/Phosphodiesterase Inhibition Studies of Carbohydrazides Based on Benzimidazole-Benzothiazine Skeleton ChemistrySelect, 2020. Kanwal, A, Ullah, S, Ahmad, M, Pelletier, J, Aslam, S, Sultan, S, Sevigny, J, Iqbal, M, Iqbal, J. DOI 10.1002/slct.202003479

Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5'NT) inhibition activities Bioorganic chemistry, 2020. Younus, HA, Hameed, A, Mahmood, A, Khan, MS, Saeed, M, Batool, F, Asari, A, Mohamad, H, Pelletier, J, Sevigny, J, Iqbal, J, Al-Rashida, M. DOI 10.1016/j.bioorg.2020.103827

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A receptor as potential antitumor agents Bioorganic & medicinal chemistry letters, 2020. Varano, F, Catarzi, D, Vincenzi, F, Pasquini, S, Pelletier, J, Lopes Rangel Fietto, J, Espindola Gelsleichter, N, Sarl, ie, M, Guilbaud, A, Sevigny, J, Varani, K, Colotta, V. DOI 10.1016/j.bmcl.2020.127067

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers Cells, 2020. Herman-de-Sousa, C, Pinheiro, AR, Paramos-de-Carvalho, D, Costa, MA, Ferreirinha, F, Magalhaes-Cardoso, T, Ribeiro, S, Pelletier, J, Sevigny, J, Correia-de-Sa, P. DOI 10.3390/cells9030651

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors Frontiers in pharmacology, 2020. Schakel, L, Schmies, CC, Idris, RM, Luo, X, Lee, SY, Lopez, V, Mirza, S, Vu, TH, Pelletier, J, Sevigny, J, Namasivayam, V, Muller, CE. DOI 10.3389/fphar.2020.01294

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach Molecular neurobiology, 2020. Azambuja, JH, Schuh, RS, Michels, LR, Gelsleichter, NE, Beckenkamp, LR, Iser, IC, Lenz, GS, de Oliveira, FH, Venturin, G, Greggio, S, daCosta, JC, Wink, MR, Sevigny, J, Stefani, MA, Battastini, AMO, Teixeira, HF, Braganhol, E. DOI 10.1007/s12035-019-01730-6

Immortalization of Mesenchymal Stromal Cells by TERT Affects Adenosine Metabolism and Impairs their Immunosuppressive Capacity Stem cell reviews and reports, 2020. Beckenkamp, LR, da Fontoura, DMS, Korb, VG, de Campos, RP, Onzi, GR, Iser, IC, Bertoni, APS, Sévigny, J, Lenz, G, Wink, MR. DOI 10.1007/s12015-020-09986-5

Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line Purinergic signalling, 2020. Willig, JB, Vianna, DRB, Beckenkamp, A, Beckenkamp, LR, Sevigny, J, Wink, MR, Buffon, A, Pilger, DA. DOI 10.1007/s11302-019-09686-x

Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold Medicinal chemistry (Shariqah (United Arab Emirates)), 2020. Afzal, S, Zaib, S, Jafari, B, Langer, P, Lecka, J, Sevigny, J, Iqbal, J. DOI 10.2174/1573406415666190614095821

HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES 2020. Jean Sévigny, Fischer Hana, Bilha, Nassir, Molhm, Zelikman, Vadim, Arad Uri, Moshe, Muller, Christa.

Functionalized Oxoindolin Hydrazine Carbothioamide Derivatives as Highly Potent Inhibitors of Nucleoside Triphosphate Diphosphohydrolases Frontiers in pharmacology, 2020. Afzal, S, Al-Rashida, M, Hameed, A, Pelletier, J, Sevigny, J, Iqbal, J. DOI 10.3389/fphar.2020.585876

Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents Bioorganic chemistry, 2020. Anbar, HS, El-Gamal, R, Ullah, S, Zaraei, SO, Al-Rashida, M, Zaib, S, Pelletier, J, Sevigny, J, Iqbal, J, El-Gamal, MI. DOI 10.1016/j.bioorg.2020.104305

Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3 Frontiers in pharmacology, 2020. Baqi, Y, Rashed, M, Schakel, L, Malik, EM, Pelletier, J, Sevigny, J, Fiene, A, Muller, CE. DOI 10.3389/fphar.2020.01282

Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes Pharmaceutical development and technology, 2020. Teixeira, FC, Bruxel, F, Azambuja, JH, Berenguer, AM, Stefani, MA, Sevigny, J, Spanevello, RM, Battastini, AMO, Teixeira, HF, Braganhol, E. DOI 10.1080/10837450.2019.1705485

Characterization and antiproliferative activity of glioma-derived extracellular vesicles Nanomedicine (London, England), 2020. Scholl, JN, de Fraga Dias, A, Pizzato, PR, Lopes, DV, Moritz, CEJ, J, rey, EHF, Souto, GD, Colombo, M, Rohden, F, Sevigny, J, Pohlmann, AR, Guterres, SS, Figueiro, F, Battastini, AMO. DOI 10.2217/nnm-2019-0431

Blockade of CD73 delays glioblastoma growth by modulating the immune environment Cancer immunology, immunotherapy : CII, 2020. Azambuja, JH, Schuh, RS, Michels, LR, Iser, IC, Beckenkamp, LR, Roliano, GG, Lenz, GS, Scholl, JN, Sevigny, J, Wink, MR, Stefani, MA, Battastini, AMO, Figueiro, F, Teixeira, HF, Braganhol, E. DOI 10.1007/s00262-020-02569-w

Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies Bioorganic chemistry, 2020. Mumtaz, A, Saeed, K, Mahmood, A, Zaib, S, Saeed, A, Pelletier, J, Sevigny, J, Iqbal, J. DOI 10.1016/j.bioorg.2020.103996

A Simple and Efficient Genetic Immunization Protocol for the Production of Highly Specific Polyclonal and Monoclonal Antibodies against the Native Form of Mammalian Proteins International journal of molecular sciences, 2020. Pelletier, J, Agonsanou, H, Manica, F, G Lavoie, E, Salem, M, Luyindula, P, Babou Kammoe, RB, Sevigny, J. DOI 10.3390/ijms21197074

The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells Purinergic signalling, 2019. Trapero, C, Vidal, A, Rodriguez-Martinez, A, Sevigny, J, Ponce, J, Coroleu, B, Matias-Guiu, X, Martin-Satue, M. DOI 10.1007/s11302-019-09656-3

Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors Bioorganic & medicinal chemistry, 2019. Semreen, MH, El-Gamal, MI, Ullah, S, Jalil, S, Zaib, S, Anbar, HS, Lecka, J, Sevigny, J, Iqbal, J. DOI 10.1016/j.bmc.2019.04.031

Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase European journal of medicinal chemistry, 2019. El-Gamal, MI, Ullah, S, Zaraei, SO, Jalil, S, Zaib, S, Zaher, DM, Omar, HA, Anbar, HS, Pelletier, J, Sevigny, J, Iqbal, J. DOI 10.1016/j.ejmech.2019.07.063

Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold European journal of medicinal chemistry, 2019. Nassir, M, Pelletier, J, Arad, U, Arguin, G, Khazanov, N, Gendron, FP, Sevigny, J, Senderowitz, H, Fischer, B. DOI 10.1016/j.ejmech.2019.111754

Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship Bioorganic chemistry, 2019. Kanwal, Kanwal, Mohammed Khan, K, Salar, U, Afzal, S, Wadood, A, Taha, M, Perveen, S, Khan, H, Lecka, J, Sevigny, J, Iqbal, J. DOI 10.1016/j.bioorg.2018.10.046

Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases Bioorganic chemistry, 2019. Andleeb, H, Hameed, S, Ejaz, SA, Khan, I, Zaib, S, Lecka, J, Sevigny, J, Iqbal, J. DOI 10.1016/j.bioorg.2019.03.067

Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression Journal of hypertension, 2019. Cardoso, AM, Manfredi, LH, Zanini, D, Bagatini, MD, Gutierres, JM, Carvalho, F, Tremblay, A, Bello-Klein, A, Rubin, MA, Morsch, VM, Sevigny, J, Schetinger, MRC. DOI 10.1097/HJH.0000000000001845

Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide-induced sepsis in rats Journal of cellular biochemistry, 2019. Miron, VV, Bottari, NB, Assmann, CE, Stefanello, N, da Costa, P, Pelinson, LP, Reichert, KP, da Silva, AD, Lopes, TF, da Cruz, IBM, Sevigny, J, Morsch, VM, Schetinger, MRC, Cardoso, AM. DOI 10.1002/jcb.27590

Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-]indoles Beilstein journal of organic chemistry, 2019. Do, HH, Ullah, S, Villinger, A, Lecka, J, Sevigny, J, Ehlers, P, Iqbal, J, Langer, P. DOI 10.3762/bjoc.15.276

NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis American journal of physiology Gastrointestinal and liver physiology, 2019. Grubisic, V, Perez-Medina, AL, Fried, DE, Sevigny, J, Robson, SC, Galligan, JJ, Gulbransen, BD. DOI 10.1152/ajpgi.00104.2019

Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies Bioorganic chemistry, 2019. Hayat, K, Afzal, S, Saeed, A, Murtaza, A, Ur Rahman, S, Khan, KM, Zaib, S, Lecka, J, Sevigny, J, Iqbal, J, Hassan, A. DOI 10.1016/j.bioorg.2019.03.019

Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE Frontiers in neuroscience, 2019. Jakovljevic, M, Lavrnja, I, Bozic, I, Milosevic, A, Bjelobaba, I, Savic, D, Sevigny, J, Pekovic, S, Nedeljkovic, N, Laketa, D. DOI 10.3389/fnins.2019.00410

Impaired Expression of Ectonucleotidases in Ectopic and Eutopic Endometrial Tissue Is in Favor of ATP Accumulation in the Tissue Microenvironment in Endometriosis International journal of molecular sciences, 2019. Trapero, C, Vidal, A, Fern, ez-Montoli, ME, Coroleu, B, Tresserra, F, Barri, P, Gomez de Ar, a, I, Sevigny, J, Ponce, J, Matias-Guiu, X, Martin-Satue, M. DOI 10.3390/ijms20225532

Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes Purinergic signalling, 2019. Nassir, M, Arad, U, Lee, SY, Journo, S, Mirza, S, Renn, C, Zimmermann, H, Pelletier, J, Sevigny, J, Muller, CE, Fischer, B. DOI 10.1007/s11302-019-09649-2

Exacerbated intestinal inflammation in P2Y deficient mice is associated with Th17 activation Biochimica et biophysica acta Molecular basis of disease, 2019. Salem, M, El Azreq, MA, Pelletier, J, Robaye, B, Aoudjit, F, Sevigny, J. DOI 10.1016/j.bbadis.2019.06.019

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis Cell metabolism, 2019. Saunders, DC, Brissova, M, Phillips, N, Shrestha, S, Walker, JT, Aram, la, R, Poffenberger, G, Flaherty, DK, Weller, KP, Pelletier, J, Cooper, T, Goff, MT, Virostko, J, Shostak, A, Dean, ED, Greiner, DL, Shultz, LD, Prasad, N, Levy, SE, Carnahan, RH, Dai, C, Sevigny, J, Powers, AC. DOI 10.1016/j.cmet.2018.10.007

Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase Bioorganic chemistry, 2019. Channar, PA, Irum, H, Mahmood, A, Shabir, G, Zaib, S, Saeed, A, Ashraf, Z, Larik, FA, Lecka, J, Sevigny, J, Iqbal, J. DOI 10.1016/j.bioorg.2019.103137

Correction to: Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes Purinergic signalling, 2019. Nassir, M, Arad, U, Lee, SY, Journo, S, Renn, SMC, Zimmermann, H, Pelletier, J, Sevigny, J, Muller, CE, Fischer, B. DOI 10.1007/s11302-019-09671-4

Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitis Scientific reports, 2019. Benmoussa, A, Diallo, I, Salem, M, Michel, S, Gilbert, C, Sevigny, J, Provost, P. DOI 10.1038/s41598-019-51092-1

Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac nonviral system as a tool to control the nucleotides level The Biochemical journal, 2019. Beckenkamp, LR, Iser, IC, Onzi, GR, Fontoura, DM, Bertoni, APS, Sevigny, J, Lenz, G, Wink, MR. DOI 10.1042/BCJ20190040

CD73 Downregulation Decreases In Vitro and In Vivo Glioblastoma Growth Molecular neurobiology, 2019. Azambuja, JH, Gelsleichter, NE, Beckenkamp, LR, Iser, IC, Fern, es, MC, Figueiro, F, Battastini, AMO, Scholl, JN, de Oliveira, FH, Spanevello, RM, Sevigny, J, Wink, MR, Stefani, MA, Teixeira, HF, Braganhol, E. DOI 10.1007/s12035-018-1240-4

Benzo[b]carbazolediones Synthesis and Inhibitory Effects on Nucleotide Pyrophosphatases/Phosphodiesterases ChemistrySelect, 2019. Do, HH, Ejaz, SA, Molenda, R, Ohlendorf, L, Villinger, A, Khan, SU, Lecka, J, Sévigny, J, Iqbal, J, Ehlers, P, Langer, P. DOI 10.1002/slct.201803061

Adenine-(methoxy)-ethoxy-P-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes Organic & biomolecular chemistry, 2019. Nassir, M, Mirza, S, Arad, U, Lee, S, Rafehi, M, Yaw Attah, I, Renn, C, Zimmermann, H, Pelletier, J, Sevigny, J, Muller, CE, Fischer, B. DOI 10.1039/c9ob02199j