Répertoire du corps professoral

National Primate Center for Pandemic Preparedness (NPCPP)
Programme: Fonds d'infrastructure de recherche en sciences biologiques (FIRSB)
Organisme(s) subventionnaire(s): Fondation Canadienne pour l'innovation (La), Ministère de l'Économie et de l'Innovation et de l'énergie, Ministère de l'Enseignement supérieur
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2024 au 31 mars 2028

Prevention of the immunopathology induced by SARS-CoV-2
Programme: Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juin 2021 au 31 mars 2025

Therapeutic approach to preserve Tfh cells and improve B cell immunity in simian immunodeficiency virus infected rhesus macaques
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2021 au 31 mars 2026

Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and C04+ T-cells for HIV cure
Programme: Subvention d'équipe : Recherche biomédicale et clinique sur le VIH/sida
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 avril 2019 au 31 mars 2025

Chaire de recherche du Canada en physiopathologie de la mort cellulaire dans les interactions hôtes-pathogènes
Programme: Chaires de recherche du Canada - Fonctionnement
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2018 au 31 mars 2025

Financements des 2 dernières années

Contribution VRRCI - 32e Congrès canadien de recherche sur le VIH/sida (ACRV 2023)
Programme: BDR - Contributions
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2023 au 30 avril 2024

Manufacturing of antigens and adjuvants for development of vaccines (MAAV)
Programme: Fonds d'innovation (FI)
Organisme(s) subventionnaire(s): Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux, Fondation du CHU de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2021 au 31 mars 2024

Louise Descamps,

Encadrements terminés dans les 5 dernières années

Julien Clain, Doctorat en microbiologie-immunologie

Vanessa Poirier, Maîtrise en microbiologie-immunologie - avec mémoire

Juliette Dewatines, Maîtrise en microbiologie-immunologie - avec mémoire

Henintsoa Rabezanahary Aina, Doctorat en microbiologie-immunologie

Publications des 5 dernières années

Double-Negative T-Cells during Acute Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections and Following Early Antiretroviral Therapy Initiation Viruses, 2024/10/14. Alexis Yero, Tao Shi, Julien A. Clain, Ouafa Zghidi-Abouzid, Gina Racine, Cecilia T. Costiniuk, Jean-Pierre Routy, Jérôme Estaquier, Mohammad-Ali Jenabian. DOI 10.3390/v16101609

ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor Biology, 2024/02/26. Adrien Corne, Florine Adolphe, Jérôme Estaquier, Sébastien Gaumer, Jean-Marc Corsi. DOI 10.3390/biology13030146

Single-cell transcriptomics reveals altered myeloid cell profiles associated with the early establishment of leishmania reservoirs 2024/02/12. Jerome Estaquier, Morgane Picard, Steven Boutrais, Vasco Rodrigues, Yasmina Fortier, Chloé Borde, Calaiselvy Soundaramourty, Julien Clain, Charles Joly Beauparlant, Gina Racine, Ouafa Zghidi-Abouzid, Arnaud Droit, Alain Pruvost, Maria Costi, Ricardo Silvestre, Anabela Cordeiro-da-Silva, Jane MacDougall, Sónia André. DOI 10.21203/rs.3.rs-3931457/v1

ATF4 Signaling in HIV Infection: Viral Subversion of a Stress Response Transcription Factor 2024/01/23. Adrien Corne, Florine Adolphe, Jérôme Estaquier, Sébastien Gaumer, Jean-Marc Corsi. DOI 10.20944/preprints202401.1708.v1

T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID Frontiers in Immunology, 2024/01/03. Renaud Cezar, Lucy Kundura, Sonia André, Claire Lozano, Thierry Vincent, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Paul Loubet, Albert Sotto, Tu-Ahn Tran, Jérôme Estaquier, Pierre Corbeau. DOI 10.3389/fimmu.2023.1335352

Is the Central Nervous System Reservoir a Hurdle for an HIV Cure? Viruses, 2023/12/05. Nazanin Mohammadzadeh, Nicolas Chomont, Jerome Estaquier, Éric Cohen, Christopher Power. DOI 10.3390/v15122385

Lipid metabolic reprogramming of hepatic CD4 + T cells during SIV infection Microbiology Spectrum, 2023/10/17. Julien A. Clain, Steven Boutrais, Juliette Dewatines, Gina Racine, Henintsoa Rabezanahary, Arnaud Droit, Ouafa Zghidi-Abouzid, Jérôme Estaquier. DOI 10.1128/spectrum.01687-23

Repetitive mRNA vaccination is required to improve the quality of broad-spectrum anti–SARS-CoV-2 antibodies in the absence of CXCL13 Science Advances, 2023/08/04. Marne Azarias-da-Silva, pierre nioche, Calaiselvy Soudaramourty, Anne Bull-Maurer, Mounira Tiouajni, kong dechuan, Ouafa Zghidi-Abouzid, Morgane Picard, Ana Frias, André Santa Cruz, Alexandre Carvalho, Carlos Capela, J Pedrosa, António Gil Castro, Paul Loubet, Albert Sotto, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Tu-Anh TRAN, Kenzo Tokunaga, Silvestre R, Pierre Corbeau, Fabrizio Mammano, Jérôme Estaquier. DOI 10.1126/sciadv.adg2122

Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques JCI Insight, 2023/07/24. Julien A. Clain, Henintsoa Rabezanahary, Gina Racine, Steven Boutrais, Calaiselvy Soundaramourty, Charles Joly Beauparlant, Mohammad-Ali Jenabian, Arnaud Droit, Petronela Ancuta, Ouafa Zghidi-Abouzid, Jérôme Estaquier. DOI 10.1172/jci.insight.167856

Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response Nature Communications, 2023/03/30. André Santa Cruz, Ana Mendes-Frias, Marne Azarias-da-Silva, Sónia André, Ana Isabel Oliveira, Olga Pires, Marta Mendes, Bárbara Fontes-Oliveira, Marta Braga, Joana Rita Lopes, Rui Domingues, Ricardo Costa, Neves da Silva, Luís, Ana Rita Matos, Cristina Ângela, Patrício Costa, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, António Gil Castro, Jérôme Estaquier, Silvestre R. DOI 10.1038/s41467-023-37368-1

Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection Cytokine & Growth Factor Reviews, 2023/02. Alexis Yero, Ralph-Sydney Mboumba Bouassa, Petronela Ancuta, Jerome Estaquier, Mohammad-Ali Jenabian. DOI 10.1016/j.cytogfr.2023.01.001

The HIV Restriction Factor Profile in the Brain Is Associated with the Clinical Status and Viral Quantities Viruses, 2023/01/23. Nazanin Mohammadzadeh, Na Zhang, William Branton, Ouafa Zghidi-Abouzid, Éric Cohen, Benjamin B. Gelman, Jerome Estaquier, Linglong Kong, Christopher Power. DOI 10.3390/v15020316

Low perforin expression in CD8+ T lymphocytes during the acute phase of severe SARS-CoV-2 infection predicts long COVID Frontiers in Immunology, 2022/10/20. Jérôme Estaquier, Lucy Kundura, Renaud Cezar, Sonia André, Mauricio Campos-Mora, Claire Lozano, Thierry Vincent, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Paul Loubet, Albert Sotto, Tu-Ahn Tran, Jérôme Estaquier, Pierre Corbeau. DOI 10.3389/fimmu.2022.1029006

Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19 Journal of Allergy and Clinical Immunology, 2022/09. Jérôme Estaquier, Lucy Kundura, Sandrine Gimenez, Renaud Cezar, Sonia André, Mehwish Younas, Yea-Lih Lin, Pierre Portalès, Claire Lozano, Charlotte Boulle, Jacques Reynes, Thierry Vincent, Clément Mettling, Philippe Pasero, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Paul Loubet, Albert Sotto, Tu-Anh Tran, Jérôme Estaquier, PIERRE CORBEAU. DOI 10.1016/j.jaci.2022.06.020

Genotypic and Phenotypic Diversity of the Replication-Competent HIV Reservoir in Treated Patients Microbiology Spectrum, 2022/08/31. Alexandre Nicolas, Julie Migraine, Jacques Dutrieux, Maud Salmona, Alexandra Tauzin, Atsuko Hachiya, Jérôme Estaquier, Jean-Michel Molina, François Clavel, Allan J. Hance, Fabrizio Mammano. DOI 10.1128/spectrum.00784-22

Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients Cell Death & Disease, 2022/08/27. Sonia André, Marne Azarias da Silva, Morgane Picard, Aurélie Alleaume-Buteau, Lucy Kundura, Renaud Cezar, Calaiselvy Soudaramourty, André Santa Cruz, Ana Mendes-Frias, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, António Gil Castro, Paul Loubet, Albert Sotto, Laurent Muller, Jean Yves LEFRANT, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Tu-Anh Tran, Ouafa Zghidi-Abouzid, Pierre Nioche, Ricardo Silvestre, Pierre Corbeau, Fabrizio Mammano, Jérôme Estaquier. DOI 10.1038/s41419-022-05190-0

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network Biomolecules, 2022/06/28. Jérôme Estaquier, Gabriel Ichim, Benjamin GIBERT, Sahil ADRIOUCH, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Dubrez Laurence, Jérôme Estaquier, Germain Gillet, Isabelle Guénal, Philippe P. Juin, Guido Kroemer, patrick legembre, Romain Levayer, Stéphen Manon, Patrick Mehlen, Olivier Meurette, olivier micheau, Bernard Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Luc Poyet, Muriel Priault, Jean-Ehrland Ricci, Franck B. Riquet, Santos A. Susin, Magali Suzanne, Pierre VACHER, Ludivine Walter, Bertrand Mollereau. DOI 10.3390/biom12070901

<i>Leishmania infantum</i> Infection of Primary Human Myeloid Cells. Microorganisms, 2022/06/17. DOI 10.3390/microorganisms10061243

Immune response in COVID-19: what is next? Cell death and differentiation, 2022/05/17. DOI 10.1038/s41418-022-01015-x

Impact of Early ARV Initiation on Relative Proportions of Effector and Regulatory CD8 T Cell in Mesenteric Lymph Nodes and Peripheral Blood During Acute SIV Infection of Rhesus Macaques. Journal of virology, 2022/03/21. DOI 10.1128/jvi.00255-22

T cell apoptosis characterizes severe Covid-19 disease Cell Death & Differentiation, 2022/01/22. DOI 10.1038/s41418-022-00936-x

Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation mBio, 2021/12/21. DOI 10.1128/mbio.02784-21

Immune-metabolic interactions between Leishmania and macrophage host Current Opinion in Microbiology, 2021/10. DOI 10.1016/j.mib.2021.07.012

[What is known about the action of endocrine disruptors on the immune system?] La Revue du praticien, 2021/09/01.

Differential Inhibition of HIV Replication by the 12 Interferon Alpha Subtypes Journal of Virology, 2021/07/12. Alexandra Tauzin, Armando Espinosa Ortiz, Olivia Blake, Calaiselvy Soundaramourty, Charles Joly-Beauparlant, Alexandre Nicolas, Arnaud Droit, Jacques Dutrieux, Jérôme Estaquier, Fabrizio Mammano. DOI 10.1128/JVI.02311-20

RALDH Activity Induced by Bacterial/Fungal Pathogens in CD16+ Monocyte-Derived Dendritic Cells Boosts HIV Infection and Outgrowth in CD4+ T Cells The Journal of Immunology, 2021/06/01. DOI 10.4049/jimmunol.2001436

The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of Leishmania major and Leishmania tropica Is Not Associated with p47phox Phosphorylation Microorganisms, 2021/05/10. DOI 10.3390/microorganisms9051025

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy The Journal of Immunology, 2021/02/01. DOI 10.4049/jimmunol.2000916

Non-human primates and Leishmania immunity Cytokine: X, 2020/12. DOI 10.1016/j.cytox.2020.100038

Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques Journal of Virology, 2020/10. Henintsoa Rabezanahary, Julien Clain, Gina Racine, Guadalupe Andreani, Ghita Benmadid-Laktout, Chloé Borde, Fabrizio Mammano, Thibault Mesplèdes, Petronela Ancuta, Ouafa Zghidi-Abouzid, Jérôme Estaquier. DOI 10.1128/jvi.01478-20

Cytokines, Apoptosis, and Immune Therapy in HIV Infection Immune Modulating Agents, 2020/10. Jerôme Estaquier, Jean-Claude Ameisen. DOI 10.1201/9781003064671-21

Cytokines and metabolic regulation: A framework of bidirectional influences affecting Leishmania infection Cytokine, 2020/09. Neelam Bodhale, Mareike Ohms, Carolina Ferreira, Inês Mesquita, Arkajyoti Mukherjee, Sónia André, Arup Sarkar, Jérôme Estaquier, Tamás Laskay, Bhaskar Saha, Ricardo Silvestre. DOI 10.1016/j.cyto.2020.155267

Antileishmanial Drugs Modulate IL-12 Expression and Inflammasome Activation in Primary Human Cells The Journal of Immunology, 2020/04/01. DOI 10.4049/jimmunol.1900590

The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis Cell Reports, 2020/03. Inês Mesquita, Carolina Ferreira, Diana Moreira, George Eduardo Gabriel Kluck, Ana Margarida Barbosa, Egídio Torrado, Ricardo Jorge Dinis-Oliveira, Luís Gafeira Gonçalves, Charles-Joly Beauparlant, Arnaud Droit, Luciana Berod, Tim Sparwasser, Neelam Bodhale, Bhaskar Saha, Fernando Rodrigues, Cristina Cunha, Agostinho Carvalho, António Gil Castro, Jérôme Estaquier, Ricardo Silvestre. DOI 10.1016/j.celrep.2020.02.098

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis PLOS Neglected Tropical Diseases, 2020/03. Carolina Ferreira, Inês Mesquita, Ana Margarida Barbosa, Nuno Sampaio Osório, Egídio Torrado, Charles-Joly Beauparlant, Arnaud Droit, Cristina Cunha, Agostinho Carvalho, Bhaskar Saha, Jerôme Estaquier, Ricardo Silvestre. DOI 10.1371/journal.pntd.0008125

Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques Mucosal Immunology, 2019/11. Henintsoa Rabezanahary, Félicien Moukambi, David Palesch, Julien Clain, Gina Racine, Guadalupe Andreani, Ghita Benmadid-Laktout, Ouafa Zghidi-Abouzid, Calayselvy Soundaramourty, Cécile Tremblay, Guido Silvestri, Jérôme Estaquier. DOI 10.1038/s41385-019-0221-x

Transcriptional Analysis of Human Skin Lesions Identifies Tryptophan-2,3-Deoxygenase as a Restriction Factor for Cutaneous Leishmania Frontiers in Cellular and Infection Microbiology, 2019/10/04. Vasco Rodrigues, Sónia André, Hasnaa Maksouri, Tarik Mouttaki, Soumiya Chiheb, Myriam Riyad, Khadija Akarid, Jérôme Estaquier. DOI 10.3389/fcimb.2019.00338

Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection Journal of Virology, 2019/09. Alexis Yero, Omar Farnos, Henintsoa Rabezanahary, Gina Racine, Jérôme Estaquier, Mohammad-Ali Jenabian. DOI 10.1128/jvi.00371-19

Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform Vaccines, 2019/06. Marie-Ève Laliberté-Gagné, Marilène Bolduc, Ariane Thérien, Caroline Garneau, Philippe Casault, Pierre Savard, Jérome Estaquier, Denis Leclerc. DOI 10.3390/vaccines7020049

Mucosal T follicular helper cells in SIV-infected rhesus macaques: contributing role of IL-27 Mucosal Immunology, 2019/05. Félicien Moukambi, Henintsoa Rabezanahary, Yasmina Fortier, Vasco Rodrigues, Julien Clain, Ghita Benmadid-Laktout, Ouafa Zghidi-Abouzid, Calayselvy Soundaramourty, Mireille Laforge, Jérôme Estaquier. DOI 10.1038/s41385-019-0174-0