Répertoire du corps professoral

A Phase 2, Randomized, Double-blind, Clinical Study of V940 (mRNA-4157) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in the Adjuvant Treatment of Participants With Renal Cell Carcinoma
Organisme(s) subventionnaire(s): Merck Canada Inc.
Type de financement: Contrat
Établissement tête: Université Laval
Du 22 septembre 2023 au25 décembre 2028

UGT2B28 IS A PROGNOSTIC AND PREDICTIVE BIOMARKER IN PROSTATE CANCER
Programme: Subvention de fonctionnement
Organisme(s) subventionnaire(s): Société de recherche sur le cancer
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2023 au31 août 2025

Targeting sex steroids to improve the response to bladder cancer immunotherapy
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2021 au30 septembre 2026

Financements des 2 dernières années

Aberrant UGT2B28 androgen inactivation pathway predicts prostate cancer progression
Programme: Subvention de fonctionnement
Organisme(s) subventionnaire(s): Société de recherche sur le cancer
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2021 au31 août 2023

Soutien à la recherche
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2017 au30 juin 2024

Publications des 5 dernières années

A phase IIb randomized placebo-controlled trial testing the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation Communications Medicine, 2024/03/22. Karine Robitaille, Marie-Hélène Guertin, Afshin Jamshidi, Hui Wen Xu, Hélène Hovington, Jean-François Pelletier, Lisanne Beaudoin, Nikunj Gevariya, Louis Lacombe, Rabi Tiguert, Yves Caumartin, Thierry Dujardin, Paul Toren, Michele Lodde, Étienne Racine, Dominique Trudel, Martine Perigny, Thierry Duchesne, Josée Savard, Pierre Julien, Yves Fradet, Vincent Fradet. DOI 10.1038/s43856-024-00456-4

Leukocytic Infiltration of Intraductal Carcinoma of the Prostate: An Exploratory Study Cancers, 2023/04/09. Mame-Kany Diop, Oscar Eduardo Molina, Mirela Birlea, Hélène LaRue, Hélène Hovington, Bernard Têtu, Louis Lacombe, Alain Bergeron, Yves Fradet, Dominique Trudel. DOI 10.3390/cancers15082217

Effects of Concentrated Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation on Quality of Life after Radical Prostatectomy: A Phase II Randomized Placebo-Controlled Trial (RCT-EPA) Nutrients, 2023/03/11. Hanane Moussa, Karine Robitaille, Jean-François Pelletier, Roxane Tourigny, Yves Fradet, Louis Lacombe, Paul Toren, Michele Lodde, Rabi Tiguert, Thierry Dujardin, Yves Caumartin, Thierry Duchesne, Pierre Julien, Josée Savard, Caroline Diorio, Vincent Fradet. DOI 10.3390/nu15061369

Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer British Journal of Cancer, 2023/01/19. Michèle Rouleau, Flora Nguyen Van Long, Véronique Turcotte, Patrick Caron, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Lévesque, Chantal Guillemette. DOI 10.1038/s41416-022-02040-w

Effects of omega-3 fatty acids supplementation on perioperative blood loss and complications after radical prostatectomy Clinical Nutrition ESPEN, 2022/02. Samuel Fradet, Jean-François Pelletier, Narcisse Singbo, Louis Lacombe, Paul Toren, Michele Lodde, Thierry Dujardin, Rabi Tiguert, Yves Fradet, Karine Robitaille, Vincent Fradet. DOI 10.1016/j.clnesp.2021.12.011

Follicle-stimulating hormone (FSH) levels prior to prostatectomy are not related to long-term oncologic or cardiovascular outcomes for men with prostate cancer. Asian journal of andrology, 2022/01. Kourbanhoussen K, Joncas FH, D Wallis CJ, Hovington H, Dagenais F, Fradet Y, Guillemette C, Lacombe L, Toren P. DOI 10.4103/aja.aja_58_21

Double inferior vena cava systems during retroperitoneal surgery: Description of a systematic approach to a rare and challenging anatomic variant. Journal of vascular surgery cases and innovative techniques, 2021/12. Chaud GJ, Lacombe L, Dagenais F. DOI 10.1016/j.jvscit.2021.12.003

Résumés AUQ 2021. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021/11. DOI 10.5489/cuaj.7674

¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is accurate for high-grade prostate cancer bone staging when compared to bone scintigraphy. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021/10. Otis-Chapados S, Goulet CR, Dubois G, Lavallée É, Dujardin T, Fradet Y, Lacombe L, Lodde M, Tiguert R, Toren P, Fradet V, Beauregard JM, Buteau FA, Pouliot F. DOI 10.5489/cuaj.7107

Canadian Urological Association guideline on the management of non-muscle-invasive bladder cancer - Full-text. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021/08. Bhindi B, Kool R, Kulkarni GS, Siemens DR, Aprikian AG, Breau RH, Brimo F, Fairey A, French C, Hanna N, Izawa JI, Lacombe L, McPherson V, Rendon RA, Kassouf W. DOI 10.5489/cuaj.7367

Canadian Urological Association guideline on the management of non-muscle-invasive bladder cancer - Abridged version. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021/08. Bhindi B, Kool R, Kulkarni GS, Siemens DR, Aprikian AG, Breau RH, Brimo F, Fairey A, French C, Hanna N, Izawa JI, Lacombe L, McPherson V, Rendon RA, Kassouf W. DOI 10.5489/cuaj.7487

Urinary oestrogen steroidome as an indicator of the risk of localised prostate cancer progression British Journal of Cancer, 2021/07/06. Jean-Philippe Emond, Louis Lacombe, Patrick Caron, Véronique Turcotte, David Simonyan, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Chantal Guillemette, Eric Lévesque. DOI 10.1038/s41416-021-01376-z

A prospective, multisite study analyzing the percentage of urological cases that can be completely managed by telemedicine. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020/10. Turcotte B, Paquet S, Blais AS, Blouin AC, Bolduc S, Bureau M, Caumartin Y, Cloutier J, Deschênes-Rompré MP, Dujardin T, Fradet Y, Lacombe L, Pouliot F. DOI 10.5489/cuaj.6862

Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer. The New England journal of medicine, 2020/09. Hussain M, Mateo J, Fizazi K, Saad F, Shore N, Sandhu S, Chi KN, Sartor O, Agarwal N, Olmos D, Thiery-Vuillemin A, Twardowski P, Roubaud G, PROfound Trial Investigators. DOI 10.1056/nejmoa2022485

Northeastern Section of the AUA 72nd Annual Meeting Abstracts Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020/09. Donnelly L, Tang J, Lian F, Higgins P, Samarakoon R, Doersch K, Abston K, Kim H, Li X, Bjazevic J, Spierling A, Al K, Razvi H, Burton J, Bjazevic J, Skog J.

Androgen receptor and immune cell PD-L1 expression in bladder tumors predicts disease recurrence and survival. World journal of urology, 2020/07. Toren P, Brisson H, Simonyan D, Hovington H, Lacombe L, Bergeron A, Fradet Y. DOI 10.1007/s00345-020-03358-x

Achieving the "trifecta" with open versus minimally invasive partial nephrectomy. World journal of urology, 2020/07. Ghavimi S, Saarela O, Pouliot F, Rendon RA, Finelli A, Kapoor A, Moore RB, Breau RH, Lavallee L, Lacombe L, Fairey A, Jewett M, Liu Z, Tanguay S, Black PC. DOI 10.1007/s00345-020-03349-y

Message from our President Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020/06. Zorn K, Bhojani N, Elterman D, Goldenberg S, So A, Paterson R, Desai M, Roehrborn R, Kaplan S, Gilling P, Berto F, Wang Z, Bjazevic J, Filler G, Romao R.

Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer. The New England journal of medicine, 2020/05. Shore ND, Saad F, Cookson MS, George DJ, Saltzstein DR, Tutrone R, Akaza H, Bossi A, van Veenhuyzen DF, Selby B, Fan X, Kang V, Walling J, Tombal B, HERO Study Investigators. DOI 10.1056/nejmoa2004325

Extragonadal Steroids Contribute Significantly to Androgen Receptor Activity and Development of Castration Resistance in Recurrent Prostate Cancer after Primary Therapy. The Journal of urology, 2020/05. Pouliot F, Rouleau M, Neveu B, Toren P, Morin F, Vélot L, Ding K, Caron P, Lacombe L, Lévesque É, Klotz L, Guillemette C. DOI 10.1097/ju.0000000000000699

Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer. The New England journal of medicine, 2020/05. Sternberg CN, Fizazi K, Saad F, Shore ND, De Giorgi U, Penson DF, Ferreira U, Efstathiou E, Madziarska K, Kolinsky MP, Cubero DIG, Noerby B, PROSPER Investigators. DOI 10.1056/nejmoa2003892

Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression. British journal of cancer, 2020/02. Lévesque E, Labriet A, Hovington H, Allain ÉP, Melo-Garcia L, Rouleau M, Brisson H, Turcotte V, Caron P, Villeneuve L, Leclercq M, Droit A, Guillemette C. DOI 10.1038/s41416-020-0749-2

Best practices for enhancing surgical research: a perspective from the Canadian Association of Chairs of Surgical Research Canadian journal of surgery. Journal canadien de chirurgie, 2019/12. Sener A, Anderson CC, Auger FA, Barralet J, Brindle M, Cayabyab FS, Fehlings MG, Lacombe L, Perrault LP, Sabbagh R, Seely AJ, Wallace C, Ellsmere J, Keijzer R. DOI 10.1503/cjs.012619

Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation. Drug metabolism and disposition: the biological fate of chemicals, 2019/11. Vaillancourt J, Turcotte V, Caron P, Villeneuve L, Lacombe L, Pouliot F, Lévesque É, Guillemette C. DOI 10.1124/dmd.119.088229

Genome-wide germline correlates of the epigenetic landscape of prostate cancer. Nature medicine, 2019/10. Houlahan KE, Shiah YJ, Gusev A, Yuan J, Ahmed M, Shetty A, Ramanand SG, Yao CQ, Bell C, O'Connor E, Huang V, Fraser M, Heisler LE, Livingstone J, Boutros PC. DOI 10.1038/s41591-019-0579-z

Résumés AUQ 2019. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2019/09. DOI 10.5489/cuaj.6229

The Immune Landscape of Cancer. Immunity, 2019/08. Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Shmulevich I. DOI 10.1016/j.immuni.2019.08.004

Receipt of 5-Alpha Reductase Inhibitors Before Radical Cystectomy: Do They Render High-Grade Bladder Tumors Less Aggressive? Clinical genitourinary cancer, 2019/08. McMartin C, Lacombe L, Fradet V, Fradet Y, Lodde M, Toren P. DOI 10.1016/j.clgc.2019.07.016

Validation of the prognostic value of NF-κB p65 in prostate cancer: A retrospective study using a large multi-institutional cohort of the Canadian Prostate Cancer Biomarker Network. PLoS medicine, 2019/07. Grosset AA, Ouellet V, Caron C, Fragoso G, Barrès V, Delvoye N, Latour M, Aprikian A, Bergeron A, Chevalier S, Fazli L, Fleshner N, Gleave M, Canadian Prostate Cancer Biomarker Network. DOI 10.1371/journal.pmed.1002847

Use and duration of antibiotic prophylaxis and the rate of urinary tract infection after radical cystectomy for bladder cancer: Results of a multicentric series. Urologic oncology, 2019/03. Haider M, Ladurner C, Mayr R, Tandogdu Z, Fritsche HM, Fradet V, Comploj E, Pycha A, Lemire F, Lacombe L, Fradet Y, Toren P, Lodde M. DOI 10.1016/j.urolonc.2019.01.017

Widespread and Functional RNA Circularization in Localized Prostate Cancer. Cell, 2019/02. Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, Zeng Y, Hua JT, Petricca J, Guo H, Wang M, Yousif F, Zhang Y, Donmez N, Ahmed M, Volik S, He HH. DOI 10.1016/j.cell.2019.01.025

Psychosocial adjustment to a prostate cancer diagnosis in a cohort of radical prostatectomy patients in Quebec, Canada. Psycho-oncology, 2019/02. Wissing MD, Chevalier S, O'Flaherty A, McKercher G, Aprikian S, Saad F, Carmel M, Lacombe L, Hamel M, Aprikian A. DOI 10.1002/pon.5031

Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody. Drug metabolism and disposition: the biological fate of chemicals, 2019/02. Émond JP, Labriet A, Desjardins S, Rouleau M, Villeneuve L, Hovington H, Brisson H, Lacombe L, Simonyan D, Caron P, Périgny M, Têtu B, Fallon JK, Lévesque E. DOI 10.1124/dmd.119.086330

Discordance between testosterone measurement methods in castrated prostate cancer patients. Endocrine connections, 2019/02. Rouleau M, Lemire F, Déry M, Thériault B, Dubois G, Fradet Y, Toren P, Guillemette C, Lacombe L, Klotz L, Saad F, Guérette D, Pouliot F. DOI 10.1530/ec-18-0476

A Comprehensive Analysis of Steroid Hormones and Progression of Localized High-Risk Prostate Cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019/02. Lévesque E, Caron P, Lacombe L, Turcotte V, Simonyan D, Fradet Y, Aprikian A, Saad F, Carmel M, Chevalier S, Guillemette C. DOI 10.1158/1055-9965.epi-18-1002