Répertoire du corps professoral

Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth
Programme: Réseau de recherche international (RRI)
Organisme(s) subventionnaire(s): Université Laval - Fonds internes, Université McGill, Université de Toronto, Institut national de la recherche agronomique
Type de financement: Subvention
Établissement tête: Université Laval
Du 18 mars 2019 au 17 mars 2025

Encadrements terminés dans les 5 dernières années

Marie-Kim St-Pierre, Maîtrise en médecine moléculaire - avec mémoire

Marie-Kim St-Pierre, Doctorat en médecine moléculaire

Fernando Gonzalez Ibanez, Doctorat en médecine moléculaire

Micaël Carrier, Maîtrise en neurosciences - avec mémoire

Micaël Carrier, Doctorat en neurosciences

Katherine Picard, Maîtrise en médecine moléculaire - avec mémoire

Katherine Picard, Doctorat en médecine moléculaire

Publications des 5 dernières années

Exploring iron deposition patterns using light and electron microscopy in the mouse brain across aging and Alzheimer’s disease pathology conditions 2024/11/08. Victor Lau, Jared VanderZwaag, Colin Murray, Marie-Ève Tremblay. DOI 10.21203/rs.3.rs-5364430/v1

Ultrastructural features of psychological stress resilience in the brain: a microglial perspective Open Biology, 2024/11. Fernando González Ibáñez, Jared VanderZwaag, Jessica Deslauriers, Marie-Ève Tremblay. DOI 10.1098/rsob.240079

A comparison of microglial morphological complexity in adult mouse brain samples using 2-dimensional and 3-dimensional image analysis tools 2024/10/02. Colin J. Murray, Eva D. Tunderman, Haley A. Vecchiarelli, Fernando González Ibáñez, Marie-Ève Tremblay. DOI 10.1101/2024.09.30.615842

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal Nature Cell Biology, 2024/02. Laura E. Newman, Sammy Weiser Novak, Gladys R. Rojas, Nimesha Tadepalle, Cara R. Schiavon, Danielle A. Grotjahn, Christina G. Towers, Marie-Ève Tremblay, Matthew P. Donnelly, Sagnika Ghosh, Michaela Medina, Sienna Rocha, Ricardo Rodriguez-Enriquez, Joshua A. Chevez, Ian Lemersal, Uri Manor, Gerald S. Shadel. DOI 10.1038/s41556-023-01343-1

Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge Brain, Behavior, and Immunity, 2024/02. Micaël Carrier, Chin W. Hui, Valérie Watters, Eva Šimončičová, Katherine Picard, Fernando González Ibáñez, Nathalie Vernoux, Arnaud Droit, Michèle Desjardins, Marie-Ève Tremblay. DOI 10.1016/j.bbi.2023.11.025

Disrupting T cell memory to promote stress resilience: A role for CD74? Brain, Behavior, and Immunity, 2023/11. Haley A. Vecchiarelli, Marie-Ève Tremblay. DOI 10.1016/j.bbi.2023.08.011

Local translation in microglial processes Nature Neuroscience, 2023/07. Haley A. Vecchiarelli, Marie-Ève Tremblay. DOI 10.1038/s41593-023-01370-z

An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease Nature Communications, 2023/03/25. Victor Lau, Leanne Ramer, Marie-Ève Tremblay. DOI 10.1038/s41467-023-37304-3

The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring Developmental Neuroscience, 2023. Sophia M. Loewen, Adriano M. Chavesa, Colin J. Murray, Marianela E. Traetta, Sophia E. Burns, Keelin H. Pekarik, Marie-Ève Tremblay. DOI 10.1159/000530185

Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring Communications Biology, 2022/12. DOI 10.1038/s42003-021-02947-9

Plasmalogens and platelet‐activating factor roles in chronic inflammatory diseases BioFactors, 2022/11. Marie‐Ève Tremblay, Zakaria A. Almsherqi, Yuru Deng. DOI 10.1002/biof.1916

Present and future of microglial pharmacology Trends in Pharmacological Sciences, 2022/08. Eva Šimončičová, Elisa Gonçalves de Andrade, Haley A. Vecchiarelli, Ifeoluwa O. Awogbindin, Charlotte I. Delage, Marie-Ève Tremblay. DOI 10.1016/j.tips.2021.11.006

Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys Cells, 2022/02/16. DOI 10.3390/cells11040691

N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice Frontiers in Cellular Neuroscience, 2022/02/10. DOI 10.3389/fncel.2022.802411

Editorial: Role of Neuroinflammation in the Neuropsychiatric and Neurological Aspects of COVID-19 Frontiers in Cellular Neuroscience, 2022/02/09. DOI 10.3389/fncel.2022.840121

Plasticity of microglia Biological Reviews, 2022/02. DOI 10.1111/brv.12797

N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development Glia, 2022/01. DOI 10.1002/glia.24088

Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle Glia, 2022/01. DOI 10.1002/glia.24090

Microglia control glutamatergic synapses in the adult mouse hippocampus Glia, 2022/01. DOI 10.1002/glia.24101

A Systematic, Open-Science Framework for Quantification of Cell-Types in Mouse Brain Sections Using Fluorescence Microscopy Frontiers in Neuroanatomy, 2021/12/06. DOI 10.3389/fnana.2021.722443

Microglia are involved in phagocytosis and extracellular digestion during Zika virus encephalitis in young adult immunodeficient mice Journal of Neuroinflammation, 2021/12. William Enlow, Maude Bordeleau, Jocelyne Piret, Fernando González Ibáñez, Olus Uyar, Marie-Christine Venable, Nathalie Goyette, Julie Carbonneau, Marie-Eve Tremblay, Guy Boivin. DOI 10.1186/s12974-021-02221-z

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice Nature Communications, 2021/12. DOI 10.1038/s41467-021-25590-8

Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner Cannabis and Cannabinoid Research, 2021/12/01. DOI 10.1089/can.2020.0170

Editorial: The Metabolism of the Neuron-Glia Unit Frontiers in Cellular Neuroscience, 2021/11/05. DOI 10.3389/fncel.2021.791389

Psychological Stress as a Risk Factor for Accelerated Cellular Aging and Cognitive Decline: The Involvement of Microglia-Neuron Crosstalk Frontiers in Molecular Neuroscience, 2021/11/04. DOI 10.3389/fnmol.2021.749737

Novel microglia-mediated mechanisms underlying synaptic loss and cognitive impairment after traumatic brain injury Brain, Behavior, and Immunity, 2021/11. DOI 10.1016/j.bbi.2021.08.210

Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice Brain, Behavior, and Immunity, 2021/10. DOI 10.1016/j.bbi.2021.07.022

Microglial functional alteration and increased diversity in the challenged brain: Insights into novel targets for intervention Brain, Behavior, & Immunity - Health, 2021/10. Marie-Ève Tremblay. DOI 10.1016/j.bbih.2021.100301

Microglia contribute to social behavioral adaptation to chronic stress Glia, 2021/10. DOI 10.1002/glia.24053

Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence Brain, Behavior, and Immunity, 2021/10. Lourdes Fernández de Cossío, Chloé Lacabanne, Maude Bordeleau, Garance Castino, Phillip Kyriakakis, Marie-Ève Tremblay. DOI 10.1016/j.bbi.2021.07.025

Purinergic signaling in nervous system health and disease: Focus on pannexin 1 Pharmacology & Therapeutics, 2021/09. DOI 10.1016/j.pharmthera.2021.107840

Editorial: The Crossroads Between Immunological Disorders and Neuropsychiatric Diseases. A Case for Schizophrenia Frontiers in Cellular Neuroscience, 2021/08/05. DOI 10.3389/fncel.2021.733997

Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring Brain, Behavior, & Immunity - Health, 2021/08. Maude Bordeleau, Lourdes Fernández de Cossío, Chloé Lacabanne, Julie C. Savage, Nathalie Vernoux, Mallar Chakravarty, Marie-Ève Tremblay. DOI 10.1016/j.bbih.2021.100281

Microglial heterogeneity in aging and Alzheimer's disease: Is sex relevant? Journal of Pharmacological Sciences, 2021/07. DOI 10.1016/j.jphs.2021.03.006

Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson’s Disease Frontiers in Cellular Neuroscience, 2021/06/15. DOI 10.3389/fncel.2021.670298

Neuroendocrine, neuroinflammatory and pathological outcomes of chronic stress: A story of microglial remodeling Neurochemistry International, 2021/05. Katherine Picard, Marie-Kim St-Pierre, Haley A. Vecchiarelli, Maude Bordeleau, Marie-Ève Tremblay. DOI 10.1016/j.neuint.2021.104987

Editorial: Synaptic Loss and Neurodegeneration Frontiers in Cellular Neuroscience, 2021/04/21. DOI 10.3389/fncel.2021.681029

Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance Molecular Neurobiology, 2021/02/24. DOI 10.1007/s12035-021-02327-8

Microglia Fighting for Neurological and Mental Health: On the Central Nervous System Frontline of COVID-19 Pandemic Frontiers in Cellular Neuroscience, 2021/02/18. DOI 10.3389/fncel.2021.647378

Brain Ultrastructure: Putting the Pieces Together Frontiers in Cell and Developmental Biology, 2021/02/18. DOI 10.3389/fcell.2021.629503

Platelets release mitochondrial antigens in systemic lupus erythematosus Science Translational Medicine, 2021/02/17. DOI 10.1126/scitranslmed.aav5928

The Intellicage system provides a reproducible and standardized method to assess behavioral changes in cuprizone-induced demyelination mouse model Behavioural Brain Research, 2021/02. Giulia Cisbani, Silvia Poggini, Nataly Laflamme, Vincent Pons, Marie-Ève Tremblay, Igor Branchi, Serge Rivest. DOI 10.1016/j.bbr.2020.113039

Structural and Functional Features of Developing Brain Capillaries, and Their Alteration in Schizophrenia Frontiers in Cellular Neuroscience, 2021/01/15. DOI 10.3389/fncel.2020.595002

From Maternal Diet to Neurodevelopmental Disorders: A Story of Neuroinflammation Frontiers in Cellular Neuroscience, 2021/01/15. DOI 10.3389/fncel.2020.612705

Sex differences in microglia as a risk factor for Alzheimer’s disease Sex and Gender Differences in Alzheimer's Disease, 2021. DOI 10.1016/b978-0-12-819344-0.00008-9

A Diversity of Cell Types, Subtypes and Phenotypes in the Central Nervous System: The Importance of Studying Their Complex Relationships Frontiers in Cellular Neuroscience, 2020/12/23. DOI 10.3389/fncel.2020.628347

Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models Frontiers in Cellular Neuroscience, 2020/12/17. DOI 10.3389/fncel.2020.592607

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain Nature Communications, 2020/12. DOI 10.1038/s41467-020-19861-z

Neuropathobiology of COVID-19: The Role for Glia Frontiers in Cellular Neuroscience, 2020/11/11. DOI 10.3389/fncel.2020.592214

Levodopa partially rescues microglial numerical, morphological, and phagolysosomal alterations in a monkey model of Parkinson’s disease Brain, Behavior, and Immunity, 2020/11. DOI 10.1016/j.bbi.2020.07.044

Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells Journal of Pharmacological Sciences, 2020/11. DOI 10.1016/j.jphs.2020.07.011

Sex Differences of Microglia and Synapses in the Hippocampal Dentate Gyrus of Adult Mouse Offspring Exposed to Maternal Immune Activation Frontiers in Cellular Neuroscience, 2020/10/15. DOI 10.3389/fncel.2020.558181

Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging Frontiers in Cellular Neuroscience, 2020/10/14. DOI 10.3389/fncel.2020.554405

Imaging the Neuroimmune Dynamics Across Space and Time Frontiers in Neuroscience, 2020/09/23. DOI 10.3389/fnins.2020.00903

Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice Nature Neuroscience, 2020/09. DOI 10.1038/s41593-020-0663-1

Remodeling microglia to a protective phenotype in Parkinson’s disease? Neuroscience Letters, 2020/09. Ifeoluwa Oluleke Awogbindin, Ismail Ogunbayode Ishola, Marie-Kim St-Pierre, Micaël Carrier, Julie C. Savage, Thérèse Di Paolo, Marie-Ève Tremblay. DOI 10.1016/j.neulet.2020.135164

The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation Frontiers in Cellular Neuroscience, 2020/08/27. DOI 10.3389/fncel.2020.00274

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration Journal of Clinical Investigation, 2020/08/17. Maud Gratuze, Cheryl E.G. Leyns, Andrew D. Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T. Kummer, Marco Colonna, Jason D. Ulrich, David M. Holtzman. DOI 10.1172/JCI138179

Neuronal hypertrophy dampens neuronal intrinsic excitability and stress responsiveness during chronic stress The Journal of Physiology, 2020/07. DOI 10.1113/jp279666

Microglia: Multiple states and multiple roles in the normal and diseased brain and spinal cord Neuroscience Letters, 2020/06. DOI 10.1016/j.neulet.2020.135019

Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet 2020/05/08. Maude Bordeleau, Chloé Lacabanne, Lourdes Fernández de Cossío, Nathalie Vernoux, Julie C. Savage, Fernando González-Ibáñez, Marie-Eve Tremblay. DOI 10.21203/rs.3.rs-25000/v1

Role of Glia in the Regulation of Sleep in Health and Disease Comprehensive Physiology, 2020/03/12. DOI 10.1002/cphy.c190022

Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets Current Behavioral Neuroscience Reports, 2020/03. DOI 10.1007/s40473-020-00199-1

An antibody for analysis of autophagy induction Nature Methods, 2020/02. DOI 10.1038/s41592-019-0661-y

Shedding Light on the Dark Side of the Microglia ASN Neuro, 2020/01. Marie-Kim St-Pierre, Eva Šimončičová, Eszter Bögi, Marie-Ève Tremblay. DOI 10.1177/1759091420925335

Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington's disease pathology 2019/12/23. Julie Savage, Marie-Kim St-Pierre, Micaël Carrier, Hassan El Hajj, Sammy Novak, Maria Gabriela Sanchez, Francesca Cicchetti, Marie-Eve Tremblay. DOI 10.21203/rs.2.19435/v1

Microglial Ultrastructure in the Hippocampus of a Lipopolysaccharide-Induced Sickness Mouse Model Frontiers in Neuroscience, 2019/12/20. DOI 10.3389/fnins.2019.01340

Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology Journal of Neuroinflammation, 2019/12. DOI 10.1186/s12974-019-1473-9

Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells Scientific Reports, 2019/12. DOI 10.1038/s41598-019-48886-8

Glial phagocytic clearance in Parkinson’s disease Molecular Neurodegeneration, 2019/12. DOI 10.1186/s13024-019-0314-8

Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations Scientific Reports, 2019/12. DOI 10.1038/s41598-019-40900-3

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain Journal of Visualized Experiments, 2019/10/27. DOI 10.3791/60510

Microglia along sex lines: From brain colonization, maturation and function, to implication in neurodevelopmental disorders Seminars in Cell & Developmental Biology, 2019/10. DOI 10.1016/j.semcdb.2019.06.001

Microglial subtypes: diversity within the microglial community The EMBO Journal, 2019/09/02. DOI 10.15252/embj.2019101997

Studying Laboratory Mice – Into the Wild Trends in Neurosciences, 2019/09. DOI 10.1016/j.tins.2019.05.004

Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy Molecular Neurobiology, 2019/09. DOI 10.1007/s12035-019-1539-9

Inflammatory mechanisms in neurodegeneration Journal of Neurochemistry, 2019/06. Michael R. Nichols, Marie‐Kim St‐Pierre, Ann‐Christin Wendeln, Nyasha J. Makoni, Lisa K. Gouwens, Evan C. Garrad, Mona Sohrabi, Jonas J. Neher, Marie‐Eve Tremblay, Colin K. Combs. DOI 10.1111/jnc.14674

Microglia and Neonatal Brain Injury Neuroscience, 2019/05. DOI 10.1016/j.neuroscience.2018.01.023

Platelet abnormalities in Huntington’s disease Journal of Neurology, Neurosurgery & Psychiatry, 2019/03. DOI 10.1136/jnnp-2018-318854

Microglia in the developing prefrontal cortex of rats show dynamic changes following neonatal disconnection of the ventral hippocampus Neuropharmacology, 2019/03. DOI 10.1016/j.neuropharm.2018.12.007

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury Nature Communications, 2019/01/31. Victor Bellver-Landete, Floriane Bretheau, Benoit Mailhot, Nicolas Vallières, Martine Lessard, Marie-Eve Janelle, Nathalie Vernoux, Marie-Ève Tremblay, Tobias Fuehrmann, Molly S. Shoichet, Steve Lacroix. DOI 10.1038/s41467-019-08446-0

Visualizing Dark Microglia Microglia, 2019. DOI 10.1007/978-1-4939-9658-2_8

Ultrastructural Analyses of Microglial Interactions with Synapses Microglia, 2019. DOI 10.1007/978-1-4939-9658-2_7

Physiology of Microglia Neuroglia in Neurodegenerative Diseases, 2019. DOI 10.1007/978-981-13-9913-8_6

Morphology of Microglia Across Contexts of Health and Disease Microglia, 2019. DOI 10.1007/978-1-4939-9658-2_2