Répertoire du corps professoral
Mohamed Chahine
Professeur titulaire
(418) 663-5747, poste 4723
Mohamed.Chahine@phc.ulaval.ca
Université Laval, CERVO
2601, chemin de la Canardière
Local F-6539
Ant venom peptides as potential inhibitors for peripheral nerve sodium channels
Programme: Subventions Alliance - Internationale - Catalyseur
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 27 décembre 2023
au26 décembre 2024
Cardiac Manifestations in Myotonic Dystrophy Type1: Arrhythmia Mechanisms and Novel Therapeutic Approaches
Programme: Peer Reviewed Medical Research Program (PRMRP)
Organisme(s) subventionnaire(s): Department of Defense (USA)
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2021
au30 juin 2025
Mechanisms of heart rhythm disorders and therapeutic interventions in myotonic dystrophy type 1
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2021
au31 mars 2026
Apis mellifera ion channels and tools to study agroecosystems contaminants
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2020
au31 mars 2025
Financements des 2 dernières années
Characterization of honeybee inward rectifier potassium (Kir) channels and their sensitivity to insecticides
Programme: Subventions Alliance - Internationale - Catalyseur
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2022
au30 septembre 2023
Human iPSC-derived neurons as a model of congenital myotonic dystrophy type 1
Organisme(s) subventionnaire(s): Association canadienne de la dystrophie musculaire (L')
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mai 2021
au30 avril 2023
Omega currents cause cardiac arrhythmias and dilated cardiomyopathy
Organisme(s) subventionnaire(s): AFM Téléthon
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2020
au23 juillet 2023
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
Impacts of DCM-linked gating pore currents on the electrophysiological characteristics of hiPSC-CM monolayers Biochemical and Biophysical Research Communications, 2024/09. Mohammed Djemai, Maroua Jalouli, Mohamed Chahine. DOI 10.1016/j.bbrc.2024.150175
Generation of a lymphoblastoid-derived induced pluripotent stem cell line (CBRCULi015-A) from a patient with congenital myotonic dystrophy Stem Cell Research, 2024/06. Thiéry De Serres-Bérard, Dominic Jauvin, Valérie Pouliot, Jack Puymirat, Mohamed Chahine. DOI 10.1016/j.scr.2024.103430
Arrhythmias and ion channelopathies causing sudden cardiac death in Hispanic/Latino and Indigenous populations Journal of Cardiovascular Electrophysiology, 2024/06. Sahil Zaveri, Mohamed Chahine, Mohamed Boutjdir. DOI 10.1111/jce.16282
Arrhythmias and Ion Channelopathies Causing Sudden Cardiac Death in Hispanic/Latino and Indigenous Populations 2024/04/13. Mohamed Boutjdir, Sahil Zaveri, Mohamed Chahine. DOI 10.22541/au.171300659.94084184/v1
Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A) Stem Cell Research, 2024/03. Mohammed Djemai, Dominic Jauvin, Hugo Poulin, Charles-Albert Chapotte-Baldacci, Mohamed Chahine. DOI 10.1016/j.scr.2024.103308
Generation of induced pluripotent stem cell lines from pediatric patients with congenital myotonic dystrophy (CBRCULi012-A and CBRCULi013-A) and age-matched controls (CBRCULi010-A and CBRCULi011-A) Stem Cell Research, 2023/10. Thiéry De Serres-Bérard, Dominic Jauvin, Jack Puymirat, Mohamed Chahine. DOI 10.1016/j.scr.2023.103234
Lymphoblastoid cell lines derived from iPSCs of a myotonic dystrophy type 1 patient carrying 700 CTG repeats (CBRCULi007-A) and a control (CBRCULi006-A) Stem Cell Research, 2023/09. Mohamed Chahine, Dominic Jauvin, Marion Pierre, Jack Puymirat, Mohamed Boutjdir. DOI 10.1016/j.scr.2023.103148
Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells Cells, 2023/08. Mohammed Djemai, Michael Cupelli, Mohamed Boutjdir, Mohamed Chahine. DOI 10.3390/cells12172168
Generation of four myotonic dystrophy type 1 patient iPSC lines (CBRCULi002-A, CBRCULi003-A, CBRCULi004-A, CBRCULi005-A) and a control (CBRCULi001-A) derived from lymphoblastoids cell lines Stem Cell Research, 2023/03. Dominic Jauvin, Marion Pierre, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine. DOI 10.1016/j.scr.2023.103037
Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1 Gene Therapy, 2022/12. Siham Ait Benichou, Dominic Jauvin, Thiéry De Serres-Bérard, Marion Pierre, Karen K. Ling, C. Frank Bennett, Frank Rigo, Genevieve Gourdon, Mohamed Chahine, Jack Puymirat. DOI 10.1038/s41434-022-00316-7
Recent Progress and Challenges in the Development of Antisense Therapies for Myotonic Dystrophy Type 1 International Journal of Molecular Sciences, 2022/11/01. Thiéry De Serres-Bérard, Siham Ait Benichou, Dominic Jauvin, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine. DOI 10.3390/ijms232113359
Enhanced Delivery of Ligand-Conjugated Antisense Oligonucleotides (C16-HA-ASO) Targeting Dystrophia Myotonica Protein Kinase Transcripts for the Treatment of Myotonic Dystrophy Type 1 Human Gene Therapy, 2022/08/01. Siham Ait Benichou, Dominic Jauvin, Thiéry De Serres-Bérard, Frank Bennett, Frank Rigo, Genevieve Gourdon, Mohamed Boutjdir, Mohamed Chahine, Jack Puymirat. DOI 10.1089/hum.2022.069
SCN2A-related epilepsy of infancy with migrating focal seizures: report of a variant with apparent gain- and loss-of-function effects Journal of Neurophysiology, 2022/05/01. Xiao-Ru Yang, Vamsi Krishna Murthy Ginjupalli, Olivier Theriault, Hugo Poulin, Juan Pablo Appendino, Ping Yee Billie Au, Mohamed Chahine. DOI 10.1152/jn.00309.2021
Racial Disparities in Ion Channelopathies and Inherited Cardiovascular Diseases Associated With Sudden Cardiac Death Journal of the American Heart Association, 2022/03/15. Mohamed Chahine, John M. Fontaine, Mohamed Boutjdir. DOI 10.1161/JAHA.121.023446
NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis eneuro, 2022/03. Jeremy B. Hui, Jose Cesar Hernandez Silva, Mari Carmen Pelaez, Myriam Sévigny, Janani Priya Venkatasubramani, Quentin Plumereau, Mohamed Chahine, Christophe D. Proulx, Chantelle F. Sephton, Paul A. Dutchak. DOI 10.1523/ENEURO.0317-21.2022
R1617Q epilepsy mutation slows NaV1.6 sodium channel inactivation and increases the persistent current and neuronal firing The Journal of Physiology, 2021/03. Hugo Poulin, Mohamed Chahine. DOI 10.1113/JP280838
Novel re-expression of L-type calcium channel Cav1.3 in left ventricles of failing human heart Heart Rhythm, 2020/07. Ujala Srivastava, Rachael Jennings-Charles, Yongxia S. Qu, Samuel Sossalla, Mohamed Chahine, Mohamed Boutjdir. DOI 10.1016/j.hrthm.2020.02.025
Differentiation of lymphoblastoid-derived iPSCs into functional cardiomyocytes, neurons and myoblasts Biochemical and Biophysical Research Communications, 2019/08. Hugo Poulin, Laurie Martineau, Véronique Racine, Jack Puymirat, Mohamed Chahine. DOI 10.1016/j.bbrc.2019.05.176
Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides Scientific Reports, 2019/01/31. Aklesso Kadala, Mercédès Charreton, Pierre Charnet, Thierry Cens, Mathieu Rousset, Mohamed Chahine, Bernard E. Vaissière, Claude Collet. DOI 10.1038/s41598-018-37278-z
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