Répertoire du corps professoral

MicroPaint: a pipeline for Meta and Genomics Real-Time Monitoring of Antibiotic Resistance Pathogens
Programme: Solutions génomiques pour l’identification, la caractérisation et la surveillance de la résistance aux antimicrobiens et des pathogènes émergents
Organisme(s) subventionnaire(s): Génome Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2023 au30 septembre 2026

MICPathoScan-Ticks: Microbiome Pathogen Scanning Tick Species and Multiplex Diagnostics of Human Pathogens
Programme: Programme d’intégration de la génomique
Organisme(s) subventionnaire(s): Génome Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2023 au30 septembre 2025

RosHAB: Rapid on-site detection of harmful algal blooms
Programme: Programme de partenariats pour les applications de la génomique (PPAG)
Organisme(s) subventionnaire(s): Génome Québec, Génome Canada
Type de financement: Subvention
Établissement tête: Institut national de la recherche scientifique, Université du Québec - INRS
Du 1 octobre 2022 au30 septembre 2025

SENTINEL : Stopping Enteric Illnesses Early - Activité 3
Programme: Programme de partenariats pour les applications de la génomique (PPAG)
Organisme(s) subventionnaire(s): Génome Canada, Génome Québec
Type de financement: Subvention
Établissement tête: University of Guelph
Du 1 janvier 2021 au30 juin 2025

SENTINEL : Stopping Enteric Illnesses Early - Activité 1
Programme: Programme de partenariats pour les applications de la génomique (PPAG)
Organisme(s) subventionnaire(s): Génome Québec, Génome Canada
Type de financement: Subvention
Établissement tête: University of Guelph
Du 1 janvier 2021 au30 juin 2025

SENTINEL : Stopping Enteric Illnesses Early
Programme: Programme de partenariats pour les applications de la génomique (PPAG)
Organisme(s) subventionnaire(s): Génome Canada, Ministère de l'agriculture, des pêcheries et de l'alimentation, Génome Québec
Type de financement: Subvention
Établissement tête: University of Guelph
Du 1 janvier 2021 au30 juin 2025

Financements des 2 dernières années

An evidence-based preclinical framework for the development of antimicrobial therapeutics in cystic fibrosis (PIPE-CF)
Organisme(s) subventionnaire(s): Cystic Fibrosis Trust
Type de financement: Subvention
Établissement tête: University of Liverpool
Du 1 octobre 2021 au31 mars 2024

Diagnosing the onset of severe Covid-19 disease
Programme: Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: University of British Columbia
Du 1 juin 2020 au31 mars 2023

A Smart Surveillance Strategy for Carbapenem-resistant Pseudomonas aeruginosa - SAMPAN
Programme: Joint Programming Initiative on Antimicrobial Resistance JPIAMR
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Érasme de Rotterdam
Du 1 octobre 2019 au1 mars 2024

Anthony Piot, Stage postdoctoral en médecine

Publications des 5 dernières années

Complete genome sequence of multidrug-resistant Enterobacter roggenkampii 0-E Microbiology Resource Announcements, 2024/03/12. Jeff Gauthier, Irena Kukavica-Ibrulj, Laure Cockenpot, Vani Mohit, Jimmy Bernier, Chantal Brisson, Roger C. Levesque. DOI 10.1128/mra.01149-23

Genomic and Phenotypic Analysis of <i>Salmonella enterica</i> Bacteriophages Identifies Two Novel Phage Species Microorganisms, 2024/03. Dr. Sudhakar Bhandare, Opeyemi U Lawal, Anna Colavecchio, Brigitte Cadieux, Yella Zahirovich-Jovich, Zeyan Zhong, Elizabeth Tompkins, Margot Amitrano, Irena Kukavica-Ibrulj, Brian Boyle, Siyun Wang, Roger C. Levesque, Pascal Delaquis, Michelle Danyluk, Lawrence Goodridge. DOI 10.3390/microorganisms12040695

Draft genome sequences of six Pseudomonas spp. and one Rheinheimera sp. isolated from oil sands process-affected water from Alberta, Canada Microbiology Resource Announcements, 2023/12/14. Kira L. Goff, Jeff Gauthier, Steven M. Shideler, Tyson Bookout, Irena Kukavica-Ibrulj, Shawn Lewenza, Roger C. Levesque. DOI 10.1128/MRA.00589-23

Mutational spectra are associated with bacterial niche Nature Communications, 2023/11/04. Christopher Ruis, Aaron Weimann, Gerry Tonkin-Hill, Arun Prasad Pandurangan, Marta Matuszewska, Gemma G. R. Murray, Roger C. Lévesque, Tom L. Blundell, R. Andres Floto, Julian Parkhill. DOI 10.1038/s41467-023-42916-w

Mutational spectra analysis reveals bacterial niche and transmission routes 2022/07/13. Christopher Ruis, Aaron Weimann, Gerry Tonkin-Hill, Arun Prasad Pandurangan, Marta Matuszewska, Gemma G. R. Murray, Roger C. Lévesque, Tom L. Blundell, R. Andres Floto, Julian Parkhill. DOI 10.1101/2022.07.13.499881

The Spruce Budworm Genome: Reconstructing the Evolutionary History of Antifreeze Proteins. Genome biology and evolution, 2022/06/07. DOI 10.1093/gbe/evac087

Liverpool Epidemic Strain Isolates of Pseudomonas aeruginosa Display High Levels of Antimicrobial Resistance during Both Planktonic and Biofilm Growth. Microbiology spectrum, 2022/06/06. DOI 10.1128/spectrum.01024-22

Draft Genome Sequences of Two Clostridium botulinum Group II Strains Carrying Phage-Like Plasmids. Microbiology resource announcements, 2022/05/18. DOI 10.1128/mra.00091-22

Application of a High-Throughput Targeted Sequence AmpliSeq Procedure to Assess the Presence and Variants of Virulence Genes in Salmonella Microorganisms, 2022/02/05. Ruimin Gao, Hongsheng Huang, Jérémie Hamel, Roger C. Levesque, Lawrence D. Goodridge, Dele Ogunremi. DOI 10.3390/microorganisms10020369

An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence. Virulence, 2021/12/01. DOI 10.1080/21505594.2021.1926408

Genome evolution drives transcriptomic and phenotypic adaptation in Pseudomonas aeruginosa during 20 years of infection Microbial Genomics, 2021/11/30. Samuel J.T. Wardell, Jeff Gauthier, Lois W. Martin, Marianne Potvin, Ben Brockway, Roger C. Levesque, Iain L. Lamont. DOI 10.1099/mgen.0.000681

Single nucleotide variants in Pseudomonas aeruginosa populations from sputum correlate with baseline lung function and predict disease progression in individuals with cystic fibrosis 2021/10/05. Morteza M. Saber, Jannik Donner, Inès Levade, Nicole Acosta, Michael D. Parkins, Brian Boyle, Roger Levesque, Dao Nguyen, B. Jesse Shapiro. DOI 10.1101/2021.10.04.21264421

Combined use of Oxford Nanopore and Illumina sequencing yields insights into soybean structural variation biology 2021/08/28. Marc-André Lemay, Jonas A. Sibbesen, Davoud Torkamaneh, Jérémie Hamel, Roger C. Levesque, François Belzile. DOI 10.1101/2021.08.26.457816

Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa. ACS infectious diseases, 2021/08/17. DOI 10.1021/acsinfecdis.1c00175

Salmonella enterica subsp. enterica virulence potential can be linked to higher survival within a dynamic in vitro human gastrointestinal model. Food microbiology, 2021/07/31. DOI 10.1016/j.fm.2021.103877

Gene-Gene Interactions Dictate Ciprofloxacin Resistance in Pseudomonas aeruginosa and Facilitate Prediction of Resistance Phenotype from Genome Sequence Data. Antimicrobial agents and chemotherapy, 2021/06/17. DOI 10.1128/aac.02696-20

Novel antimicrobial anionic cecropins from the spruce budworm feature a poly-L-aspartic acid C-terminus. Proteins, 2021/05/24. DOI 10.1002/prot.26142

Transmission, adaptation and geographical spread of the Pseudomonas aeruginosa Liverpool epidemic strain. Microbial genomics, 2021/03/15. DOI 10.1099/mgen.0.000511

Complete Genome Sequence of a Pseudomonas Species Isolated from Tailings Pond Water in Alberta, Canada. Microbiology resource announcements, 2021/03/04. DOI 10.1128/mra.01174-20

The Pseudomonas aeruginosa whole genome sequence: A 20th anniversary celebration Advances in Microbial Physiology, 2021. Brinkman, F.S.L., Winsor, G.L., Done, R.E., Filloux, A., Francis, V.I., Goldberg, J.B., Greenberg, E.P., Han, K., Hancock, R.E.W., Haney, C.H., Häußler, S., Klockgether, J., Lamont, I.L., Levesque, R.C., Lory, S., Nikel, P.I., Porter, S.L., Scurlock, M.W., Schweizer, H.P., Tümmler, B., Wang, M., Welch, M.. DOI 10.1016/bs.ampbs.2021.07.001

Sequencing, assembly and annotation of the whole-insect genome of Lymantria dispar dispar, the European gypsy moth G3: Genes, Genomes, Genetics, 2021. Sparks, M.E., Hebert, F.O., Johnston, J.S., Hamelin, R.C., Cusson, M., Levesque, R.C., Gundersen-Rindal, D.E.. DOI 10.1093/g3journal/jkab150

Bacteriophage-Induced Lipopolysaccharide Mutations in Escherichia coli Lead to Hypersensitivity to Food Grade Surfactant Sodium Dodecyl Sulfate Antibiotics, 2020/08. DOI 10.3390/antibiotics9090552

The Salmonella enterica Plasmidome as a Reservoir of Antibiotic Resistance. Microorganisms, 2020/07/08. DOI 10.3390/microorganisms8071016

Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors of Salmonella Virulence. mSphere, 2020/06/10. DOI 10.1128/msphere.00293-20

Phenomic and genomic approaches to studying the inhibition of multiresistant Salmonella enterica by microcin J25. Environmental microbiology, 2020/05/15. DOI 10.1111/1462-2920.15045

Structural insights into the putative bacterial acetylcholinesterase ChoE and its substrate inhibition mechanism. The Journal of biological chemistry, 2020/05/05. DOI 10.1074/jbc.ra119.011809

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa. Frontiers in chemistry, 2020/05/04. DOI 10.3389/fchem.2020.00204

A New Whole Genome Culture-Independent Diagnostic Test (WG-CIDT) for Rapid Detection of Salmonella in Lettuce. Frontiers in microbiology, 2020/04/17. DOI 10.3389/fmicb.2020.00602

Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections. Molecular pharmaceutics, 2020/04/06. DOI 10.1021/acs.molpharmaceut.9b00968

A megaplasmid family driving dissemination of multidrug resistance in Pseudomonas. Nature communications, 2020/03/13. DOI 10.1038/s41467-020-15081-7

Bacteriophage-Insensitive Mutants of Antimicrobial-Resistant Salmonella Enterica are Altered in their Tetracycline Resistance and Virulence in Caco-2 Intestinal Cells. International journal of molecular sciences, 2020/03/10. DOI 10.3390/ijms21051883

Continent-wide population genomic structure and phylogeography of North America's most destructive conifer defoliator, the spruce budworm (Choristoneura fumiferana). Ecology and evolution, 2020/01/07. DOI 10.1002/ece3.5950

Similar yet different: Phylogenomic analysis to delineate Salmonella and Citrobacter species boundaries BMC Genomics, 2020. Pilar, A.V.C., Petronella, N., Dussault, F.M., Verster, A.J., Bekal, S., Levesque, R.C., Goodridge, L., Tamber, S.. DOI 10.1186/s12864-020-06780-y

Reuse of voucher specimens provides insights into the genomic associations and taxonomic value of wing colour and genitalic differences in a pest group (Lepidoptera: Tortricidae: Choristoneura) Systematic Entomology, 2020. French, R.L.K., Lebunasin, P.N.A., Brunet, B.M.T., Lumley, L.M., Cusson, M., Levesque, R.C., Sperling, F.A.H.. DOI 10.1111/syen.12416

Reassessment of the status of Lymantria albescens and Lymantria postalba (Lepidoptera: Erebidae: Lymantriinae) as distinct ‘Asian gypsy moth’ species, using both mitochondrial and nuclear sequence data Systematic Entomology, 2020. Djoumad, A., Nisole, A., Stewart, D., Holden, D., Zahiri, R., Inoue, M.N., Martemyanov, V.V., Levesque, R.C., Hamelin, R.C., Cusson, M.. DOI 10.1111/syen.12410

Comparative genomic analysis of 142 bacteriophages infecting Salmonella enterica subsp. enterica BMC Genomics, 2020. Gao, R., Naushad, S., Moineau, S., Levesque, R., Goodridge, L., Ogunremi, D.. DOI 10.1186/s12864-020-6765-z

Inactivation of Salmonella enterica on post-harvest cantaloupe and lettuce by a lytic bacteriophage cocktail. Current research in food science, 2019/11/28. DOI 10.1016/j.crfs.2019.11.004

Expansion of LINEs and species-specific DNA repeats drives genome expansion in Asian Gypsy Moths. Scientific reports, 2019/11/11. DOI 10.1038/s41598-019-52840-z

Diversity and Host Specificity Revealed by Biological Characterization and Whole Genome Sequencing of Bacteriophages Infecting <i>Salmonella enterica</i>. Viruses, 2019/09/14. DOI 10.3390/v11090854

Temporal variation in spatial genetic structure during population outbreaks: Distinguishing among different potential drivers of spatial synchrony. Evolutionary applications, 2019/08/24. DOI 10.1111/eva.12852

Culture-Dependent Bioprospecting of Bacterial Isolates From the Canadian High Arctic Displaying Antibacterial Activity. Frontiers in microbiology, 2019/08/09. DOI 10.3389/fmicb.2019.01836

Reservoirs of resistance: polymyxin resistance in veterinary-associated companion animal isolates of <i>Pseudomonas aeruginosa</i>. The Veterinary record, 2019/06/25. DOI 10.1136/vr.105075

The Pseudomonas aeruginosa Population among Cystic Fibrosis Patients in Quebec, Canada: a Disease Hot Spot without Known Epidemic Isolates. Journal of clinical microbiology, 2019/05/24. DOI 10.1128/jcm.02019-18

Fate of 43 <i>Salmonella</i> Strains on Lettuce and Tomato Seedlings. Journal of food protection, 2019/05/24. DOI 10.4315/0362-028x.jfp-18-435

Major Release of 161 Whole-Genome Sequences from the International Pseudomonas Consortium Database. Microbiology resource announcements, 2019/03/28. DOI 10.1128/mra.00013-19

Species interactions and distinct microbial communities in high Arctic permafrost affected cryosols are associated with the CH<inf>4</inf> and CO<inf>2</inf> gas fluxes Environmental Microbiology, 2019. Altshuler, I., Hamel, J., Turney, S., Magnuson, E., Lévesque, R., Greer, C.W., Whyte, L.G.. DOI 10.1111/1462-2920.14715

A needle in a haystack: a multigene TaqMan assay for the detection of Asian gypsy moths in bulk pheromone trap samples Biological Invasions, 2019. Stewart, D., Nisole, A., Djoumad, A., Zahiri, R., Lamarche, J., Levesque, R.C., Hamelin, R.C., Cusson, M.. DOI 10.1007/s10530-019-01943-9

A megaplasmid family responsible for dissemination of multidrug resistance in Pseudomonas bioRxiv, 2019. Cazares, A., Moore, M.P., Grimes, M., Emond-Rhéault, J.-G., Wright, L.L., Pongchaikul, P., Santanirand, P., Levesque, R.C., Fothergill, J.L., Winstanley, C.. DOI 10.1101/630780

The Pseudomonas aeruginosa Pan-Genome Provides New Insights on Its Population Structure, Horizontal Gene Transfer, and Pathogenicity. Genome biology and evolution, 2019/01/01. DOI 10.1093/gbe/evy259