Répertoire du corps professoral

Financements des 2 dernières années

A transcriptome- and proteome-wide association study of non-alcoholic fatty liver disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2021 au 30 septembre 2024

Identification of novel therapeutic targets for calcific aortic valve stenosis using integrative genomics
Programme: Subventions de recherche
Organisme(s) subventionnaire(s): Fondation des maladies du coeur et de l'AVC du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2019 au 31 juillet 2023

Integrative genomics and functional analyses to uncover the molecular mechanisms involved in bicuspid aortic valve disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2019 au 31 mars 2024

Finding the molecular drivers of calcific aortic valve stenosis
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2018 au 31 mars 2023

Déterminants moléculaires et environnementaux de l’adiposité viscérale et du risque cardio-métabolique : un pas vers la médecine personnalisée
Programme: Établissement de jeunes chercheurs - Juniors 1
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2018 au 30 juin 2023

Ran Xu, Doctorat en médecine moléculaire

Pardis Zamani, Maîtrise en médecine moléculaire - avec mémoire

Pardis Zamani, Doctorat en médecine moléculaire

Veronique Boumtje, Doctorat en médecine moléculaire

Ursula Houessou, Doctorat en médecine moléculaire

Encadrements terminés dans les 5 dernières années

Hasanga Dilshan Manik Purage, Doctorat en sciences cliniques et biomédicales

Publications des 5 dernières années

Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights PLOS Genetics, 2024/05/30. Sébastien Renaut, Victoria Saavedra Armero, Dominique K. Boudreau, Nathalie Gaudreault, Patrice Desmeules, Sébastien Thériault, Patrick Mathieu, Philippe Joubert, Yohan Bossé. DOI 10.1371/journal.pgen.1011301

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation Nature Communications, 2024/03/18. Sébastien Thériault, Zhonglin Li, Erik Abner, Jian’an Luan, Hasanga D. Manikpurage, Ursula Houessou, Pardis Zamani, Mewen Briend, Dominique K. Boudreau, Nathalie Gaudreault, Lily Frenette, Déborah Argaud, Manel Dahmene, François Dagenais, Marie-Annick Clavel, Philippe Pibarot, Benoit J. Arsenault, S. Matthijs Boekholdt, Nicholas J. Wareham, Tõnu Esko, Patrick Mathieu, Yohan Bossé. DOI 10.1038/s41467-024-46639-4

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets 2023/12/07. Eloi Gagnon, Arnaud Girard, Jérôme Bourgault, Erik Abner, Dipender Gill, Sébastien Thériault, Marie-Claude Vohl, André Tchernof, Tõnu Esko, Patrick Mathieu, Benoit J. Arsenault. DOI 10.1101/2023.12.05.23299567

Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis Circulation: Genomic and Precision Medicine, 2023/10. Hasanga D. Manikpurage, Audrey Paulin, Arnaud Girard, Aida Eslami, Patrick Mathieu, Sébastien Thériault, Benoit J. Arsenault. DOI 10.1161/CIRCGEN.123.004137

Integrative Analysis of the Blood Proteome by Mendelian Randomization Reveals Regulatory Networks in Calcific Aortic Valve Disease 2023/07/28. Mewen Briend, Louis-Hippolyte Minvielle Moncla, Valentine Duclos, Samuel Mathieu, Anne Rufiange, Sébastien Thériault, Benoit Arsenault, Yohan Bossé, Patrick Mathieu. DOI 10.1101/2023.07.26.23293222

The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis European Heart Journal, 2023/06/01. Sébastien Thériault, Patrick Mathieu, Yohan Bossé. DOI 10.1093/eurheartj/ehad134

Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study Journal of Translational Medicine, 2023/01/30. Eloi Gagnon, Patricia L. Mitchell, Hasanga D. Manikpurage, Erik Abner, Nele Taba, Tõnu Esko, Nooshin Ghodsian, Sébastien Thériault, Patrick Mathieu, Benoit J. Arsenault. DOI 10.1186/s12967-022-03799-5

Sex-specific impact of body weight on atherosclerotic cardiovascular disease incidence in individuals with and without ideal cardiovascular health 2023/01/18. Audrey Paulin, Hasanga D. Manikpurage, Jean-Pierre Després, Sébastien Thériault, Benoit J. Arsenault. DOI 10.1101/2023.01.16.23284627

Greater adherence to the 2019 Canada’s Food Guide recommendations on healthy food choices reduces the risk of cardiovascular disease in adults: a prospective analysis of UK Biobank data The American Journal of Clinical Nutrition, 2022/12. Didier Brassard, Hasanga D Manikpurage, Sébastien Thériault, Benoît J Arsenault, Benoît Lamarche. DOI 10.1093/ajcn/nqac256

Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease Metabolites, 2022/05. Émilie Gobeil, Ina Maltais-Payette, Nele Taba, Francis Brière, Nooshin Ghodsian, Erik Abner, Jérôme Bourgault, Eloi Gagnon, Hasanga Dilshan Manikpurage, Christian Couture, Patricia Mitchell, Patrick Mathieu, François Julien, Jacques Corbeil, Marie-Claude Vohl, Sébastien Thériault, Tõnu Esko, André Tchernof, Benoit Arsenault. DOI 10.3390/metabo12050440

Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve PLOS Genetics, 2022/01/18. Arnaud Chignon, Déborah Argaud, Marie-Chloé Boulanger, Ghada Mkannez, Valentin Bon-Baret, Zhonglin Li, Sébastien Thériault, Yohan Bossé, Patrick Mathieu. DOI 10.1371/journal.pgen.1010010

Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin Journal of the American Society of Nephrology, 2022. Joseph, C.B., Mariniello, M., Yoshifuji, A., Schiano, G., Lake, J., Marten, J., Richmond, A., Huffman, J.E., Campbell, A., Harris, S.E., Troyanov, S., Cocca, M., Robino, A., Thériault, S., Eckardt, K.-U., Wuttke, M., Cheng, Y., Corre, T., Kolcic, I., Black, C., Bruat, V., Concas, M.P., Sala, C., Aeschbacher, S., Schaefer, F., Bergmann, S., Campbell, H., Olden, M., Polasek, O., Porteous, D.J., Deary, I.J., Madore, F., Awadalla, P., Girotto, G., Ulivi, S., Conen, D., Wuehl, E., Olinger, E., Wilson, J.F., Bochud, M., Köttgen, A., Hayward, C., Devuyst, O.. DOI 10.1681/ASN.2021040491

Mendelian randomization of circulating proteome identifies actionable targets in heart failure BMC Genomics, 2022. Moncla, L.-H.M., Mathieu, S., Sylla, M.S., Bossé, Y., Thériault, S., Arsenault, B.J., Mathieu, P.. DOI 10.1186/s12864-022-08811-2

Mendelian Randomization of Circulating Proteome Identifies Actionable Targets in Heart Failure ResearchSquare, 2022. Moncla, L.-H.M., Mathieu, S., Bossé, Y., Thériault, S., Arsenault, B., Mathieu, P.. DOI 10.21203/rs.3.rs-1547537

Genetic risk score for intracranial aneurysms to predict aneurysmal subarachnoid hemorrhage and identify associations with patient characteristics medRxiv, 2022. Bakker, M.K., Kanning, J.P., Abraham, G., Martinsen, A.E., Winsvold, B.S., Zwart, J.-A., Bourcier, R., Sawada, T., Koido, M., Kamatani, Y., Morel, S., Amouyel, P., Debette, S., Bijlenga, P., Berrandou, T., Ganesh, S.K., Bouatia-Naji, N., Jones, G., Bown, M., Rinkel, G.J.E., Veldink, J.H., Ruigrok, Y.M., Aamodt, A.H., Skogholt, A.H., Brumpton, B.M., Willer, C.J., Sandset, E.C., Kristoffersen, E.S., Ellekjær, H., Heuch, I., Zwart, J.-A., Nielsen, J.B., Hagen, K., Hveem, K., Fritsche, L.G., Thomas, L.F., Pedersen, L.M., Gabrielsen, M.E., Holmen, O.L., Børte, S., Zhou, W., Abboud, S., Pandolfo, M., Thijs, V., Leys, D., Bodenant, M., Louillet, F., Touzé, E., Mas, J.-L., Samson, Y., Leder, S., Léger, A., Deltour, S., Crozier, S., Méresse, I., Canaple, S., Godefroy, O., Giroud, M., Béjot, Y., Decavel, P., Medeiros, E., Montiel, P., Moulin, T., Vuillier, F., Dallongeville, J., Metso, A.J., Metso, T., Tatlisumak, T., Grond-Ginsbach, C., Lichy, C., Kloss, M., Werner, I., Arnold, M.-L., Dos Santos, M., Grau, A., Dichgans, M., Thomas-Feles, C., Weber, R., Brandt, T., Pezzini, A., De Giuli, V., Caria, F., Poli, L., Padovani, A., Bersano, A., Lanfranconi, S., Beretta, S., Ferrarese, C., Giacolone, G., Paolucci, S., Lyrer, P., Engelter, S., Fluri, F., Hatz, F., Gisler, D., Bonati, L., Gensicke, H., Amort, M., Markus, H., Majersik, J., Worrall, B., Southerland, A., Cole, J., Kittner, S., Evangelou, E., Warren, H.R., Gao, H., Ntritsos, G., Dimou, N., Esko, T., Mägi, R., Milani, L., Almgren, P., Boutin, T., Debette, S., Ding, J., Giulianini, F., Holliday, E.G., Jackson, A.U., Li-Gao, R., Lin, W.-Y., Luan, J., Mangino, M., Oldmeadow, C., Prins, B.P., Qian, Y., Sargurupremraj, M., Shah, N., Surendran, P., Thériault, S., Verweij, N., Willems, S.M., Zhao, J.-H., Amouyel, P., Connell, J., de Mutsert, R., Doney, A.S.F., Farrall, M., Menni, C., Morris, A.D., Noordam, R., Paré, G., Poulter, N.R., Shields, D.C., Stanton, A., Thom, S., Abecasis, G., Amin, N., Arking, D.E., Ayers, K.L., Barbieri, C.M., Batini, C., Bis, J.C., Blake, T., Bochud, M., Boehnke, M., Boerwinkle, E., Boomsma, D.I., Bottinger, E.P., Braund, P.S., Brumat, M., Campbell, A., Campbell, H., Chakravarti, A., Chambers, J.C., Chauhan, G., Ciullo, M., Cocca, M., Collins, F., Cordell, H.J., Davies, G., de Borst, M.H., de Geus, E.J., Deary, I.J., Deelen, J., Del Greco, F.M., Demirkale, C.Y., Dörr, M., Ehret, G.B., Elosua, R., Enroth, S., Erzurumluoglu, A.M., Ferreira, T., Frånberg, M., Franco, O.H., Gandin, I., Gasparini, P., Giedraitis, V., Gieger, C., Girotto, G., Goel, A., Gow, A.J., Gudnason, V., Guo, X., Gyllensten, U., Hamsten, A., Harris, T.B., Harris, S.E., Hartman, C.A., Havulinna, A.S., Hicks, A.A., Hofer, E., Hofman, A., Hottenga, J.-J., Huffman, J.E., Hwang, S.-J., Ingelsson, E., James, A., Jansen, R., Jarvelin, M.-R., Joehanes, R., Johansson, Å., Johnson, A.D., Joshi, P.K., Jousilahti, P., Jukema, J.W., Jula, A., Kähönen, M., Kathiresan, S., Keavney, B.D., Khaw, K.-T., Knekt, P., Knight, J., Kolcic, I., Kooner, J.S., Koskinen, S., Kristiansson, K., Kutalik, Z., Laan, M., Larson, M., Launer, L.J., Lehne, B., Lehtimäki, T., Liewald, D.C.M., Lin, L., Lind, L., Lindgren, C.M., Liu, Y., Loos, R.J.F., Lopez, L.M., Lu, Y., Lyytikäinen, L.-P., Mahajan, A., Mamasoula, C., Marrugat, J., Marten, J., Milaneschi, Y., Morgan, A., Morris, A.P., Morrison, A.C., Munson, P.J., Nalls, M.A., Nandakumar, P., Nelson, C.P., Niiranen, T., Nolte, I.M., Nutile, T., Oldehinkel, A.J., Oostra, B.A., O'Reilly, P.F., Org, E., Padmanabhan, S., Palmas, W., Palotie, A., Pattie, A., Penninx, B.W.J.H., Perola, M., Peters, A., Polasek, O., Pramstaller, P.P., Nguyen, Q.T., Raitakari, O.T., Rettig, R., Rice, K., Ridker, P.M., Ried, J.S., Riese, H., Ripatti, S., Robino, A., Rose, L.M., Rotter, J.I., Rudan, I., Ruggiero, D., Saba, Y., Sala, C.F., Salomaa, V., Samani, N.J., Sarin, A.-P., Schmidt, R., Schmidt, H., Shrine, N., Siscovick, D., Smith, A.V., Snieder, H., Sõber, S., Sorice, R., Starr, J.M., Stott, D.J., Strachan, D.P., Strawbridge, R.J., Sundström, J., Swertz, M.A., Taylor, K.D., Teumer, A., Tobin, M.D., Tomaszewski, M., Toniolo, D., Traglia, M., Trompet, S., Tuomilehto, J., Tzourio, C., Uitterlinden, A.G., Vaez, A., van der Most, P.J., van Duijn, C.M., Verwoert, G.C., Vitart, V., Völker, U., Vollenweider, P., Vuckovic, D., Watkins, H., Wild, S.H., Willemsen, G., Wilson, J.F., Wright, A.F., Yao, J., Zemunik, T., Zhang, W., Attia, J.R., Butterworth, A.S., Chasman, D.I., Conen, D., Cucca, F., Danesh, J., Hayward, C., Howson, J.M.M., Laakso, M., Lakatta, E.G., Langenberg, C., Melander, O., Mook-Kanamori, D.O., Palmer, C.N.A., Risch, L., Scott, R.A., Scott, R.J., Sever, P., Spector, T.D., van der Harst, P., Wareham, N.J., Zeggini, E., Levy, D., Munroe, P.B., Newton-Cheh, C., Brown, M.J., Metspalu, A., Psaty, B.M., Wain, L.V., Elliott, P., Caulfield, M.J., Gormley, P., Anttila, V., Winsvold, B.S., Palta, P., Esko, T., Pers, T.H., Farh, K.-H., Cuenca-Leon, E., Muona, M., Furlotte, N.A., Kurth, T., Ingason, A., McMahon, G., Ligthart, L., Terwindt, G.M., Kallela, M., Freilinger, T.M., Ran, C., Gordon, S.G., Stam, A.H., Steinberg, S., Borck, G., Koiranen, M., Quaye, L., Adams, H.H.H., Lehtimäki, T., Sarin, A.-P., Wedenoja, J., Hinds, D.A., Buring, J.E., Schürks, M., Ridker, P.M., Hrafnsdottir, M.G., Stefansson, H., Ring, S.M., Hottenga, J.-J., Färkkilä, M., Artto, V., Kaunisto, M., Vepsäläinen, S., Malik, R., Heath, A.C., Madden, P.A.F., Martin, N.G., Montgomery, G.W., Kurki, M.I., Kals, M., Mägi, R., Pärn, K., Hämäläinen, E., Huang, H., Byrnes, A.E., Franke, L., Huang, J., Stergiakouli, E., Lee, P.H., Sandor, C., Webber, C., Cader, Z., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Eriksson, J.G., Salomaa, V., Heikkilä, K., Loehrer, E., Uitterlinden, A.G., Hofman, A., van Duijn, C.M., Cherkas, L., Pedersen, L.M., Stubhaug, A., Nielsen, C.S., Männikkö, M., Mihailov, E., Milani, L., Göbel, H., Esserlind, A.-L., Christensen, A.F., Hansen, T.F., Werge, T., Kaprio, J., Aromaa, A.J., Raitakari, O., Ikram, M.A., Spector, T., Järvelin, M.-R., Metspalu, A., Kubisch, C., Strachan, D.P., Ferrari, M.D., Belin, A.C., Dichgans, M., Wessman, M., van den Maagdenberg, A.M.J.M., Zwart, J.-A., Boomsma, D.I., Smith, G.D., Stefansson, K., Eriksson, N., Daly, M.J., Neale, B.M., Olesen, J., Chasman, D.I., Nyholt, D.R., Palotie, A., Bourcier, R., Walters, R.G., Malik, R., Dichgans, M., Sargurupremraj, M., Tatlisumak, T., Debette, S., Rinkel, G.J.E., Worrall, B.B., Pera, J., Slowik, A., Broderick, J.P., Werring, D.J., Woo, D., Kamatani, Y.. DOI 10.1101/2022.04.29.22274404

Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms iScience, 2022. Mathieu, S., Briend, M., Abner, E., Couture, C., Li, Z., Bossé, Y., Thériault, S., Esko, T., Arsenault, B.J., Mathieu, P.. DOI 10.1016/j.isci.2022.104992

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways Nature Communications, 2022. Young, W.J., Lahrouchi, N., Isaacs, A., Duong, T.V., Foco, L., Ahmed, F., Brody, J.A., Salman, R., Noordam, R., Benjamins, J.-W., Haessler, J., Lyytikäinen, L.-P., Repetto, L., Concas, M.P., van den Berg, M.E., Weiss, S., Baldassari, A.R., Bartz, T.M., Cook, J.P., Evans, D.S., Freudling, R., Hines, O., Isaksen, J.L., Lin, H., Mei, H., Moscati, A., Müller-Nurasyid, M., Nursyifa, C., Qian, Y., Richmond, A., Roselli, C., Ryan, K.A., Tarazona-Santos, E., Thériault, S., van Duijvenboden, S., Warren, H.R., Yao, J., Raza, D., Aeschbacher, S., Ahlberg, G., Alonso, A., Andreasen, L., Bis, J.C., Boerwinkle, E., Campbell, A., Catamo, E., Cocca, M., Cutler, M.J., Darbar, D., De Grandi, A., De Luca, A., Ding, J., Ellervik, C., Ellinor, P.T., Felix, S.B., Froguel, P., Fuchsberger, C., Gögele, M., Graff, C., Graff, M., Guo, X., Hansen, T., Heckbert, S.R., Huang, P.L., Huikuri, H.V., Hutri-Kähönen, N., Ikram, M.A., Jackson, R.D., Junttila, J., Kavousi, M., Kors, J.A., Leal, T.P., Lemaitre, R.N., Lin, H.J., Lind, L., Linneberg, A., Liu, S., MacFarlane, P.W., Mangino, M., Meitinger, T., Mezzavilla, M., Mishra, P.P., Mitchell, R.N., Mononen, N., Montasser, M.E., Morrison, A.C., Nauck, M., Nauffal, V., Navarro, P., Nikus, K., Pare, G., Patton, K.K., Pelliccione, G., Pittman, A., Porteous, D.J., Pramstaller, P.P., Preuss, M.H., Raitakari, O.T., Reiner, A.P., Ribeiro, A.L.P., Rice, K.M., Risch, L., Schlessinger, D., Schotten, U., Schurmann, C., Shen, X., Shoemaker, M.B., Sinagra, G., Sinner, M.F., Soliman, E.Z., Stoll, M., Strauch, K., Tarasov, K., Taylor, K.D., Tinker, A., Trompet, S., Uitterlinden, A., Völker, U., Völzke, H., Waldenberger, M., Weng, L.-C., Whitsel, E.A., Wilson, J.G., Avery, C.L., Conen, D., Correa, A., Cucca, F., Dörr, M., Gharib, S.A., Girotto, G., Grarup, N., Hayward, C., Jamshidi, Y., Järvelin, M.-R., Jukema, J.W., Kääb, S., Kähönen, M., Kanters, J.K., Kooperberg, C., Lehtimäki, T., Lima-Costa, M.F., Liu, Y., Loos, R.J.F., Lubitz, S.A., Mook-Kanamori, D.O., Morris, A.P., O’Connell, J.R., Olesen, M.S., Orini, M., Padmanabhan, S., Pattaro, C., Peters, A., Psaty, B.M., Rotter, J.I., Stricker, B., van der Harst, P., van Duijn, C.M., Verweij, N., Wilson, J.F., Arking, D.E., Ramirez, J., Lambiase, P.D., Sotoodehnia, N., Mifsud, B., Newton-Cheh, C., Munroe, P.B.. DOI 10.1038/s41467-022-32821-z

Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease Human Genomics, 2022. Chignon, A., Mathieu, S., Rufiange, A., Argaud, D., Voisine, P., Bossé, Y., Arsenault, B.J., Thériault, S., Mathieu, P.. DOI 10.1186/s40246-022-00381-4

Elevated Lipoprotein(a) and Risk of Atrial Fibrillation: An Observational and Mendelian Randomization Study Journal of the American College of Cardiology, 2022. Mohammadi-Shemirani, P., Chong, M., Narula, S., Perrot, N., Conen, D., Roberts, J.D., Thériault, S., Bossé, Y., Lanktree, M.B., Pigeyre, M., Paré, G.. DOI 10.1016/j.jacc.2022.02.018

A false-positive troponin assay leading to the misdiagnosis of myopericarditis,Résultat de troponine faux positif à l'origine d'un diagnostic erroné de myopéricardite CMAJ. Canadian Medical Association Journal, 2022. Laguë, M., Turgeon, P.Y., Thériault, S., Steinberg, C.. DOI 10.1503/cmaj.211842-f

A false-positive troponin assay leading to the misdiagnosis of myopericarditis CMAJ, 2022. Laguë, M., Turgeon, P.Y., Thériault, S., Steinberg, C.. DOI 10.1503/CMAJ.211842

A Multivariable Mendelian Randomization Analysis Disentangling The Causal Relations Between Abdominal Obesity, Non-Alcoholic Fatty Liver Disease and Cardiometabolic Diseases ResearchSquare, 2022. Gagnon, E., Pelletier, W., Gobeil, É., Bourgault, J., Manikpurage, H., Maltais-Payette, I., Abner, E., Taba, N., Esko, T., Mitchell, P., Ghodsian, N., Després, J.-P., Vohl, M.-C., Tchernof, A., Thériault, S., Arsenault, B.. DOI 10.21203/rs.3.rs-1336425

Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men Circulation: Genomic and Precision Medicine, 2021/12. Hasanga D. Manikpurage, Aida Eslami, Nicolas Perrot, Zhonglin Li, Christian Couture, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault. DOI 10.1161/CIRCGEN.121.003452

A multidimensional Mendelian randomization study on the impact of gut dysbiosis on chronic diseases and human longevity 2021/08/25. Éloi Gagnon, Patricia L. Mitchell, Hasanga Manikpurage, Erik Abner, Nele Taba, Tõnu Esko, Nooshin Ghodsian, Sébastien Thériault, Patrick Mathieu, Benoit J. Arsenault. DOI 10.1101/2021.08.20.21262026

Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis Metabolites, 2021/07. Raphaëlle Bourgeois, Jérôme Bourgault, Audrey-Anne Despres, Nicolas Perrot, Jakie Guertin, Arnaud Girard, Patricia L. Mitchell, Clarisse Gotti, Sylvie Bourassa, Corey A. Scipione, Nathalie Gaudreault, Michael B. Boffa, Marlys L. Koschinsky, Philippe Pibarot, Arnaud Droit, Sébastien Thériault, Patrick Mathieu, Yohan Bossé, Benoit Arsenault. DOI 10.3390/metabo11070459

A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men 2021/04/27. Hasanga D. Manikpurage, Aida Eslami, Nicolas Perrot, Zhonglin Li, Christian Couture, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault. DOI 10.1101/2021.04.25.21256083

System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan Circulation: Genomic and Precision Medicine, 2021/04. Valentin Bon-Baret, Arnaud Chignon, Marie-Chloé Boulanger, Zhonglin Li, Deborah Argaud, Benoit J. Arsenault, Sébastien Thériault, Yohan Bossé, Patrick Mathieu. DOI 10.1161/CIRCGEN.120.003196

Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses Circulation: Genomic and Precision Medicine, 2021. Guertin, J., Kaiser, Y., Manikpurage, H., Perrot, N., Bourgeois, R., Couture, C., Wareham, N.J., Bossé, Y., Pibarot, P., Stroes, E.S.G., Mathieu, P., Clavel, M.-A., Thériault, S., Boekholdt, S.M., Arsenault, B.J.. DOI 10.1161/CIRCGEN.120.003271

Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (Nature Genetics, (2020), 52, 12, (1314-1332), 10.1038/s41588-020-00713-x) Nature Genetics, 2021. Surendran, P., Feofanova, E.V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A.T., Cartwright, J.H., Hellwege, J.N., Giri, A., Tragante, V., Thorleifsson, G., Liu, D.J., Prins, B.P., Stewart, I.D., Cabrera, C.P., Eales, J.M., Akbarov, A., Auer, P.L., Bielak, L.F., Bis, J.C., Braithwaite, V.S., Brody, J.A., Daw, E.W., Warren, H.R., Drenos, F., Nielsen, S.F., Faul, J.D., Fauman, E.B., Fava, C., Ferreira, T., Foley, C.N., Franceschini, N., Gao, H., Giannakopoulou, O., Giulianini, F., Gudbjartsson, D.F., Guo, X., Harris, S.E., Havulinna, A.S., Helgadottir, A., Huffman, J.E., Hwang, S.-J., Kanoni, S., Kontto, J., Larson, M.G., Li-Gao, R., Lindström, J., Lotta, L.A., Lu, Y., Luan, J., Mahajan, A., Malerba, G., Masca, N.G.D., Mei, H., Menni, C., Mook-Kanamori, D.O., Mosen-Ansorena, D., Müller-Nurasyid, M., Paré, G., Paul, D.S., Perola, M., Poveda, A., Rauramaa, R., Richard, M., Richardson, T.G., Sepúlveda, N., Sim, X., Smith, A.V., Smith, J.A., Staley, J.R., Stanáková, A., Sulem, P., Thériault, S., Thorsteinsdottir, U., Trompet, S., Varga, T.V., Velez Edwards, D.R., Veronesi, G., Weiss, S., Willems, S.M., Yao, J., Young, R., Yu, B., Zhang, W., Zhao, J.-H., Zhao, W., Zhao, W., Evangelou, E., Aeschbacher, S., Asllanaj, E., Blankenberg, S., Bonnycastle, L.L., Bork-Jensen, J., Brandslund, I., Braund, P.S., Burgess, S., Cho, K., Christensen, C., Connell, J., Mutsert, R., Dominiczak, A.F., Dörr, M., Eiriksdottir, G., Farmaki, A.-E., Gaziano, J.M., Grarup, N., Grove, M.L., Hallmans, G., Hansen, T., Have, C.T., Heiss, G., Jørgensen, M.E., Jousilahti, P., Kajantie, E., Kamat, M., Käräjämäki, A.M., Karpe, F., Koistinen, H.A., Kovesdy, C.P., Kuulasmaa, K., Laatikainen, T., Lannfelt, L., Lee, I.-T., Lee, W.-J., de Boer, R.A., van der Harst, P., van der Meer, P., Verweij, N., Linneberg, A., Martin, L.W., Moitry, M., Nadkarni, G., Neville, M.J., Palmer, C.N.A., Papanicolaou, G.J., Pedersen, O., Peters, J., Poulter, N., Rasheed, A., Rasmussen, K.L., Rayner, N.W., Mägi, R., Renström, F., Rettig, R., Rossouw, J., Schreiner, P.J., Sever, P.S., Sigurdsson, E.L., Skaaby, T., Sun, Y.V., Sundstrom, J., Thorgeirsson, G., Esko, T., Trabetti, E., Tsao, P.S., Tuomi, T., Turner, S.T., Tzoulaki, I., Vaartjes, I., Vergnaud, A.-C., Willer, C.J., Wilson, P.W.F., Witte, D.R., Yonova-Doing, E., Zhang, H., Aliya, N., Almgren, P., Amouyel, P., Asselbergs, F.W., Barnes, M.R., Blakemore, A.I., Boehnke, M., Bots, M.L., Bottinger, E.P., Buring, J.E., Chambers, J.C., Chen, Y.-D.I., Chowdhury, R., Conen, D., Correa, A., Davey Smith, G., Boer, R.A., Deary, I.J., Dedoussis, G., Deloukas, P., Di Angelantonio, E., Elliott, P., Butterworth, A.S., Danesh, J., Langenberg, C., McCarthy, M.I., Franks, P.W., Rolandsson, O., Wareham, N.J., Felix, S.B., Ferrières, J., Ford, I., Fornage, M., Franks, P.W., Franks, S., Frossard, P., Gambaro, G., Gaunt, T.R., Groop, L., Gudnason, V., Harris, T.B., Hayward, C., Hennig, B.J., Herzig, K.-H., Ingelsson, E., Tuomilehto, J., Järvelin, M.-R., Jukema, J.W., Kardia, S.L.R., Kee, F., Kooner, J.S., Kooperberg, C., Launer, L.J., Lind, L., Loos, R.J.F., Majumder, A.S., Laakso, M., McCarthy, M.I., Melander, O., Mohlke, K.L., Murray, A.D., Nordestgaard, B.G., Orho-Melander, M., Packard, C.J., Padmanabhan, S., Palmas, W., Polasek, O., Porteous, D.J., Prentice, A.M., Province, M.A., Relton, C.L., Rice, K., Ridker, P.M., Rolandsson, O., Rosendaal, F.R., Rotter, J.I., Rudan, I., Salomaa, V., Samani, N.J., Sattar, N., Sheu, W.H.-H., Smith, B.H., Soranzo, N., Spector, T.D., Starr, J.M., Sebert, S., Taylor, K.D., Lakka, T.A., Timpson, N.J., Tobin, M.D., Prins, B.P., Zeggini, E., van der Harst, P., van der Meer, P., Ramachandran, V.S., Verweij, N., Virtamo, J., Völker, U., Weir, D.R., Zeggini, E., Charchar, F.J., Hellwege, J.N., Giri, A., Edwards, D.R.V., Cho, K., Gaziano, J.M., Kovesdy, C.P., Sun, Y.V., Tsao, P.S., Wilson, P.W.F., Edwards, T.L., Hung, A.M., O’Donnell, C.J., Wareham, N.J., Langenberg, C., Tomaszewski, M., Butterworth, A.S., Caulfield, M.J., Danesh, J., Edwards, T.L., Holm, H., Lindgren, C.M., Liu, C., Manning, A.K., Morris, A.P., Morrison, A.C., O’Donnell, C.J., Psaty, B.M., Saleheen, D., Stefansson, K., Boerwinkle, E., Chasman, D.I., Levy, D., Newton-Cheh, C., Munroe, P.B., Howson, J.M.M.. DOI 10.1038/s41588-021-00832-z

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank Communications Biology, 2021. Valette, K., Li, Z., Bon-Baret, V., Chignon, A., Bérubé, J.-C., Eslami, A., Lamothe, J., Gaudreault, N., Joubert, P., Obeidat, M., van den Berge, M., Timens, W., Sin, D.D., Nickle, D.C., Hao, K., Labbé, C., Godbout, K., Côté, A., Laviolette, M., Boulet, L.-P., Mathieu, P., Thériault, S., Bossé, Y.. DOI 10.1038/s42003-021-02227-6

Oximetry neither to prescribe long-term oxygen therapy nor to screen for severe hypoxaemia ERJ Open Research, 2021. Lacasse, Y., Thériault, S., St-Pierre, B., Bernard, S., Sériès, F., Bernatchez, H.J., Maltais, F.. DOI 10.1183/23120541.00272-2021

Mendelian randomization analysis identifies blood tyrosine levels as a biomarker of non-alcoholic fatty liver disease medRxiv, 2021. Gobeil, É., Maltais-Payette, I., Taba, N., Brière, F., Ghodsian, N., Abner, E., Bourgault, J., Gagnon, É., Manikpurage, H.D., Couture, C., Mitchell, P.L., Mathieu, P., Julien, F., Corbeil, J., Vohl, M.-C., Thériault, S., Esko, T., Tchernof, A., Arsenault, B.J.. DOI 10.1101/2021.11.26.21266879

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization medRxiv, 2021. Young, W.J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J.A., Salman, R., Noordam, R., Benjamins, J.-W., Haessler, J., Lyytikäinen, L.-P., Repetto, L., Concas, M.P., van den Berg, M.E., Weiss, S., Baldassari, A.R., Bartz, T.M., Cook, J.P., Evans, D.S., Freudling, R., Hines, O., Isaksen, J.L., Lin, H., Mei, H., Moscati, A., Müller-Nurasyid, M., Nursyifa, C., Qian, Y., Richmond, A., Roselli, C., Ryan, K.A., Tarazona-Santos, E., Thériault, S., van Duijvenboden, S., Warren, H.R., Yao, J., Raza, D., Aeschbacher, S., Ahlberg, G., Alonso, A., Andreasen, L., Bis, J.C., Boerwinkle, E., Campbell, A., Catamo, E., Cocca, M., Cutler, M.J., Darbar, D., de Grandi, A., de Luca, A., Ding, J., Ellervik, C., Ellinor, P.T., Felix, S.B., Froguel, P., Fuchsberger, C., Gögele, M., Graff, C., Graff, M., Guo, X., Hansen, T., Heckbert, S.R., Huang, P.L., Huikuri, H.V., Hutri-Kähönen, N., Ikram, M.A., Jackson, R.D., Junttila, J., Kavousi, M., Kors, J.A., Leal, T.P., Lemaitre, R.N., Lin, H.J., Lind, L., Linneberg, A., Liu, S., MacFarlane, P.W., Mangino, M., Meitinger, T., Mezzavilla, M., Mishra, P.P., Mitchell, R.N., Mononen, N., Montasser, M.E., Morrison, A.C., Nauck, M., Nauffal, V., Navarro, P., Nikus, K., Pare, G., Patton, K.K., Pelliccione, G., Pittman, A., Porteous, D.J., Pramstaller, P.P., Preuss, M.H., Raitakari, O.T., Reiner, A.P., Ribeiro, A.L.P., Rice, K.M., Risch, L., Schlessinger, D., Schotten, U., Schurmann, C., Shen, X., Shoemaker, M.B., Sinagra, G., Sinner, M.F., Soliman, E.Z., Stoll, M., Strauch, K., Tarasov, K., Taylor, K.D., Tinker, A., Trompet, S., Uitterlinden, A., Völker, U., Völzke, H., Waldenberger, M., Weng, L.-C., Whitsel, E.A., Wilson, J.G., Avery, C.L., Conen, D., Correa, A., Cucca, F., Dörr, M., Gharib, S.A., Girotto, G., Grarup, N., Hayward, C., Jamshidi, Y., Järvelin, M.-R., Jukema, J.W., Kääb, S., Kähönen, M., Kanters, J.K., Kooperberg, C., Lehtimäki, T., Lima-Costa, M.F., Liu, Y., Loos, R.J.F., Lubitz, S.A., Mook-Kanamori, D.O., Morris, A.P., O'Connell, J.R., Olesen, M.S., Orini, M., Padmanabhan, S., Pattaro, C., Peters, A., Psaty, B.M., Rotter, J.I., Stricker, B., van der Harst, P., van Duijn, C.M., Verweij, N., Wilson, J.F., Arking, D.E., Ramirez, J., Lambiase, P.D., Sotoodehnia, N., Mifsud, B., Newton-Cheh, C., Munroe, P.B.. DOI 10.1101/2021.11.04.21265866

Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis iScience, 2021. Chignon, A., Rosa, M., Boulanger, M.-C., Argaud, D., Devillers, R., Bon-Baret, V., Mkannez, G., Li, Z., Rufiange, A., Gaudreault, N., Gosselin, D., Thériault, S., Bossé, Y., Mathieu, P.. DOI 10.1016/j.isci.2021.102241

Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery ddisease ResearchSquare, 2021. Chignon, A., Mathieu, S., Rufiange, A., Argaud, D., Voisine, P., Bossé, Y., Arsenault, B., Thériault, S., Mathieu, P.. DOI 10.21203/rs.3.rs-978033

Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease Cell Reports Medicine, 2021. Ghodsian, N., Abner, E., Emdin, C.A., Gobeil, É., Taba, N., Haas, M.E., Perrot, N., Manikpurage, H.D., Gagnon, É., Bourgault, J., St-Amand, A., Couture, C., Mitchell, P.L., Bossé, Y., Mathieu, P., Vohl, M.-C., Tchernof, A., Thériault, S., Khera, A.V., Esko, T., Arsenault, B.J.. DOI 10.1016/j.xcrm.2021.100437

Circulating Galectin-3 Levels Are Not Associated with Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study Journal of Clinical Endocrinology and Metabolism, 2021. Tremblay, M., Perrot, N., Ghodsian, N., Gobeil, É., Couture, C., Mitchell, P.L., Thériault, S., Arsenault, B.J.. DOI 10.1210/clinem/dgab144

A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases Aging Cell, 2021. Perrot, N., Pelletier, W., Bourgault, J., Couture, C., Li, Z., Mitchell, P.L., Ghodsian, N., Bossé, Y., Thériault, S., Mathieu, P., Arsenault, B.J.. DOI 10.1111/acel.13497

A multivariable Mendelian randomization analysis disentangling the causal relations between abdominal obesity, non-alcoholic fatty liver disease and cardiometabolic diseases medRxiv, 2021. Pelletier, W., Gagnon, É., Gobeil, É., Bourgault, J., Manikpurage, H.D., Maltais-Payette, I., Abner, E., Taba, N., Esko, T., Mitchell, P.L., Ghodsian, N., Després, J.-P., Vohl, M.-C., Tchernof, A., Thériault, S., Arsenault, B.J.. DOI 10.1101/2021.09.28.21264201

A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization CJC Open, 2021. Bourgeois, R., Girard, A., Perrot, N., Guertin, J., Mitchell, P.L., Couture, C., Gotti, C., Bourassa, S., Poggio, P., Mass, E., Capoulade, R., Scipione, C.A., Després, A.-A., Couture, P., Droit, A., Pibarot, P., Boffa, M.B., Thériault, S., Koschinsky, M.L., Mathieu, P., Arsenault, B.J.. DOI 10.1016/j.cjco.2020.11.019

Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis Communications Biology, 2020/08/28. Zhonglin Li, Nathalie Gaudreault, Benoit J. Arsenault, Patrick Mathieu, Yohan Bossé, Sébastien Thériault. DOI 10.1038/s42003-020-01210-x

Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases Communications Biology, 2020. Chignon, A., Bon-Baret, V., Boulanger, M.-C., Li, Z., Argaud, D., Bossé, Y., Thériault, S., Arsenault, B.J., Mathieu, P.. DOI 10.1038/s42003-020-0937-x

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction Nature Communications, 2020. Ntalla, I., Weng, L.-C., Cartwright, J.H., Hall, A.W., Sveinbjornsson, G., Tucker, N.R., Choi, S.H., Chaffin, M.D., Roselli, C., Barnes, M.R., Mifsud, B., Warren, H.R., Hayward, C., Marten, J., Cranley, J.J., Concas, M.P., Gasparini, P., Boutin, T., Kolcic, I., Polasek, O., Rudan, I., Araujo, N.M., Lima-Costa, M.F., Ribeiro, A.L.P., Souza, R.P., Tarazona-Santos, E., Giedraitis, V., Ingelsson, E., Mahajan, A., Morris, A.P., Del Greco M, F., Foco, L., Gögele, M., Hicks, A.A., Cook, J.P., Lind, L., Lindgren, C.M., Sundström, J., Nelson, C.P., Riaz, M.B., Samani, N.J., Sinagra, G., Ulivi, S., Kähönen, M., Mishra, P.P., Mononen, N., Nikus, K., Caulfield, M.J., Dominiczak, A., Padmanabhan, S., Montasser, M.E., O’Connell, J.R., Ryan, K., Shuldiner, A.R., Aeschbacher, S., Conen, D., Risch, L., Thériault, S., Hutri-Kähönen, N., Lehtimäki, T., Lyytikäinen, L.-P., Raitakari, O.T., Barnes, C.L.K., Campbell, H., Joshi, P.K., Wilson, J.F., Isaacs, A., Kors, J.A., van Duijn, C.M., Huang, P.L., Gudnason, V., Harris, T.B., Launer, L.J., Smith, A.V., Bottinger, E.P., Loos, R.J.F., Nadkarni, G.N., Preuss, M.H., Correa, A., Mei, H., Wilson, J., Meitinger, T., Müller-Nurasyid, M., Peters, A., Waldenberger, M., Mangino, M., Spector, T.D., Rienstra, M., van de Vegte, Y.J., van der Harst, P., Verweij, N., Kääb, S., Schramm, K., Sinner, M.F., Strauch, K., Cutler, M.J., Fatkin, D., London, B., Olesen, M., Roden, D.M., Benjamin Shoemaker, M., Gustav Smith, J., Biggs, M.L., Bis, J.C., Brody, J.A., Psaty, B.M., Rice, K., Sotoodehnia, N., De Grandi, A., Fuchsberger, C., Pattaro, C., Pramstaller, P.P., Ford, I., Wouter Jukema, J., Macfarlane, P.W., Trompet, S., Dörr, M., Felix, S.B., Völker, U., Weiss, S., Havulinna, A.S., Jula, A., Sääksjärvi, K., Salomaa, V., Guo, X., Heckbert, S.R., Lin, H.J., Rotter, J.I., Taylor, K.D., Yao, J., de Mutsert, R., Maan, A.C., Mook-Kanamori, D.O., Noordam, R., Cucca, F., Ding, J., Lakatta, E.G., Qian, Y., Tarasov, K.V., Levy, D., Lin, H., Newton-Cheh, C.H., Lunetta, K.L., Murray, A.D., Porteous, D.J., Smith, B.H., Stricker, B.H., Uitterlinden, A., van den Berg, M.E., Haessler, J., Jackson, R.D., Kooperberg, C., Peters, U., Reiner, A.P., Whitsel, E.A., Alonso, A., Arking, D.E., Boerwinkle, E., Ehret, G.B., Soliman, E.Z., Avery, C.L., Gogarten, S.M., Kerr, K.F., Laurie, C.C., Seyerle, A.A., Stilp, A., Assa, S., Abdullah Said, M., Yldau van der Ende, M., Lambiase, P.D., Orini, M., Ramirez, J., Van Duijvenboden, S., Arnar, D.O., Gudbjartsson, D.F., Holm, H., Sulem, P., Thorleifsson, G., Thorolfsdottir, R.B., Thorsteinsdottir, U., Benjamin, E.J., Tinker, A., Stefansson, K., Ellinor, P.T., Jamshidi, Y., Lubitz, S.A., Munroe, P.B.. DOI 10.1038/s41467-020-15706-x

Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans Heart, 2020. Perrot, N., Theriault, S., Rigade, S., Chen, H.Y., Dina, C., Martinsson, A., Boekholdt, S.M., Capoulade, R., Le Tourneau, T., Messika-Zeitoun, D., Engert, J.C., Wareham, N.J., Clavel, M.-A., Pibarot, P., Smith, J.G., Schott, J.J., Mathieu, P., Bosse, Y., Thanassoulis, G., Arsenault, B.J.. DOI 10.1136/heartjnl-2020-316722

Identification of circulating proteins associated with blood pressure using Mendelian randomization Circulation: Genomic and Precision Medicine, 2020. Thériault, S., Sjaarda, J., Chong, M., Hess, S., Gerstein, H., Paré, G.. DOI 10.1161/CIRCGEN.119.002605

Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD European Respiratory Journal, 2020. Gupta, N., Gaudreault, N., Thériault, S., Li, P.Z., Henry, C., Kirby, M., Maltais, F., Tan, W., Bourbeau, J., Bossé, Y.. DOI 10.1183/13993003.00958-2020

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis JACC: Basic to Translational Science, 2020. Perrot, N., Valerio, V., Moschetta, D., Boekholdt, S.M., Dina, C., Chen, H.Y., Abner, E., Martinsson, A., Manikpurage, H.D., Rigade, S., Capoulade, R., Mass, E., Clavel, M.-A., Le Tourneau, T., Messika-Zeitoun, D., Wareham, N.J., Engert, J.C., Polvani, G., Pibarot, P., Esko, T., Smith, J.G., Mathieu, P., Thanassoulis, G., Schott, J.-J., Bossé, Y., Camera, M., Thériault, S., Poggio, P., Arsenault, B.J.. DOI 10.1016/j.jacbts.2020.05.004

Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation Circulation: Arrhythmia and Electrophysiology, 2020. Shoemaker, M.B., Husser, D., Roselli, C., Al Jazairi, M., Chrispin, J., Kühne, M., Neumann, B., Knight, S., Sun, H., Mohanty, S., Shaffer, C., Thériault, S., Rinke, L.L., Siland, J.E., Crawford, D.M., Ueberham, L., Zardkoohi, O., Büttner, P., Geelhoed, B., Blum, S., Aeschbacher, S., Smith, J.D., Van Wagoner, D.R., Freudling, R., Müller-Nurasyid, M., Montgomery, J., Yoneda, Z., Wells, Q., Issa, T., Weeke, P., Jacobs, V., Van Gelder, I.C., Hindricks, G., Barnard, J., Calkins, H., Darbar, D., Michaud, G., Kaä¨b, S., Ellinor, P., Natale, A., Chung, M., Nazarian, S., Cutler, M.J., Sinner, M.F., Conen, D., Rienstra, M., Bollmann, A., Roden, D.M., Lubitz, S.. DOI 10.1161/CIRCEP.119.007676

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals Nature Genetics, 2020. Surendran, P., Feofanova, E.V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A.T., Cartwright, J.H., Hellwege, J.N., Giri, A., Tragante, V., Thorleifsson, G., Liu, D.J., Prins, B.P., Stewart, I.D., Cabrera, C.P., Eales, J.M., Akbarov, A., Auer, P.L., Bielak, L.F., Bis, J.C., Braithwaite, V.S., Brody, J.A., Daw, E.W., Warren, H.R., Drenos, F., Nielsen, S.F., Faul, J.D., Fauman, E.B., Fava, C., Ferreira, T., Foley, C.N., Franceschini, N., Gao, H., Giannakopoulou, O., Giulianini, F., Gudbjartsson, D.F., Guo, X., Harris, S.E., Havulinna, A.S., Helgadottir, A., Huffman, J.E., Hwang, S.-J., Kanoni, S., Kontto, J., Larson, M.G., Li-Gao, R., Lindström, J., Lotta, L.A., Lu, Y., Luan, J., Mahajan, A., Malerba, G., Masca, N.G.D., Mei, H., Menni, C., Mook-Kanamori, D.O., Mosen-Ansorena, D., Müller-Nurasyid, M., Paré, G., Paul, D.S., Perola, M., Poveda, A., Rauramaa, R., Richard, M., Richardson, T.G., Sepúlveda, N., Sim, X., Smith, A.V., Smith, J.A., Staley, J.R., Stanáková, A., Sulem, P., Thériault, S., Thorsteinsdottir, U., Trompet, S., Varga, T.V., Velez Edwards, D.R., Veronesi, G., Weiss, S., Willems, S.M., Yao, J., Young, R., Yu, B., Zhang, W., Zhao, J.-H., Zhao, W., Zhao, W., Evangelou, E., Aeschbacher, S., Asllanaj, E., Blankenberg, S., Bonnycastle, L.L., Bork-Jensen, J., Brandslund, I., Braund, P.S., Burgess, S., Cho, K., Christensen, C., Connell, J., Mutsert, R., Dominiczak, A.F., Dörr, M., Eiriksdottir, G., Farmaki, A.-E., Gaziano, J.M., Grarup, N., Grove, M.L., Hallmans, G., Hansen, T., Have, C.T., Heiss, G., Jørgensen, M.E., Jousilahti, P., Kajantie, E., Kamat, M., Käräjämäki, A.M., Karpe, F., Koistinen, H.A., Kovesdy, C.P., Kuulasmaa, K., Laatikainen, T., Lannfelt, L., Lee, I.-T., Lee, W.-J., de Boer, R.A., van der Harst, P., van der Meer, P., Verweij, N., Linneberg, A., Martin, L.W., Moitry, M., Nadkarni, G., Neville, M.J., Palmer, C.N.A., Papanicolaou, G.J., Pedersen, O., Peters, J., Poulter, N., Rasheed, A., Rasmussen, K.L., Rayner, N.W., Mägi, R., Renström, F., Rettig, R., Rossouw, J., Schreiner, P.J., Sever, P.S., Sigurdsson, E.L., Skaaby, T., Sun, Y.V., Sundstrom, J., Thorgeirsson, G., Esko, T., Trabetti, E., Tsao, P.S., Tuomi, T., Turner, S.T., Tzoulaki, I., Vaartjes, I., Vergnaud, A.-C., Willer, C.J., Wilson, P.W.F., Witte, D.R., Yonova-Doing, E., Zhang, H., Aliya, N., Almgren, P., Amouyel, P., Asselbergs, F.W., Barnes, M.R., Blakemore, A.I., Boehnke, M., Bots, M.L., Bottinger, E.P., Buring, J.E., Chambers, J.C., Chen, Y.-D.I., Chowdhury, R., Conen, D., Correa, A., Davey Smith, G., Boer, R.A., Deary, I.J., Dedoussis, G., Deloukas, P., Di Angelantonio, E., Elliott, P., Butterworth, A.S., Danesh, J., Langenberg, C., McCarthy, M.I., Franks, P.W., Rolandsson, O., Wareham, N.J., Felix, S.B., Ferrières, J., Ford, I., Fornage, M., Franks, P.W., Franks, S., Frossard, P., Gambaro, G., Gaunt, T.R., Groop, L., Gudnason, V., Harris, T.B., Hayward, C., Hennig, B.J., Herzig, K.-H., Ingelsson, E., Tuomilehto, J., Järvelin, M.-R., Jukema, J.W., Kardia, S.L.R., Kee, F., Kooner, J.S., Kooperberg, C., Launer, L.J., Lind, L., Loos, R.J.F., Majumder, A.S., Laakso, M., McCarthy, M.I., Melander, O., Mohlke, K.L., Murray, A.D., Nordestgaard, B.G., Orho-Melander, M., Packard, C.J., Padmanabhan, S., Palmas, W., Polasek, O., Porteous, D.J., Prentice, A.M., Province, M.A., Relton, C.L., Rice, K., Ridker, P.M., Rolandsson, O., Rosendaal, F.R., Rotter, J.I., Rudan, I., Salomaa, V., Samani, N.J., Sattar, N., Sheu, W.H.-H., Smith, B.H., Soranzo, N., Spector, T.D., Starr, J.M., Sebert, S., Taylor, K.D., Lakka, T.A., Timpson, N.J., Tobin, M.D., Prins, B.P., Zeggini, E., van der Harst, P., van der Meer, P., Ramachandran, V.S., Verweij, N., Virtamo, J., Völker, U., Weir, D.R., Zeggini, E., Charchar, F.J., Hellwege, J.N., Giri, A., Edwards, D.R.V., Cho, K., Gaziano, J.M., Kovesdy, C.P., Sun, Y.V., Tsao, P.S., Wilson, P.W.F., Edwards, T.L., Hung, A.M., O’Donnell, C.J., Langenberg, C., Tomaszewski, M., Butterworth, A.S., Caulfield, M.J., Danesh, J., Edwards, T.L., Holm, H., Lindgren, C.M., Liu, C., Manning, A.K., Morris, A.P., Morrison, A.C., O’Donnell, C.J., Psaty, B.M., Saleheen, D., Stefansson, K., Boerwinkle, E., Chasman, D.I., Levy, D., Newton-Cheh, C., Munroe, P.B., Howson, J.M.M.. DOI 10.1038/s41588-020-00713-x

Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk A Mendelian Randomization Analysis JAMA Network Open, 2020. Arsenault, B.J., Pelletier, W., Kaiser, Y., Perrot, N., Couture, C., Khaw, K.-T., Wareham, N.J., Bossé, Y., Pibarot, P., Stroes, E.S.G., Mathieu, P., Thériault, S., Boekholdt, S.M.. DOI 10.1001/jamanetworkopen.2020.0129

Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids with Aortic Stenosis JAMA Cardiology, 2020. Chen, H.Y., Cairns, B.J., Small, A.M., Burr, H.A., Ambikkumar, A., Martinsson, A., Thériault, S., Munter, H.M., Steffen, B., Zhang, R., Levinson, R.T., Shaffer, C.M., Rong, J., Sonestedt, E., Dufresne, L., Ljungberg, J., Näslund, U., Johansson, B., Ranatunga, D.K., Whitmer, R.A., Budoff, M.J., Nguyen, A., Vasan, R.S., Larson, M.G., Harris, W.S., Damrauer, S.M., Stark, K.D., Boekholdt, S.M., Wareham, N.J., Pibarot, P., Arsenault, B.J., Mathieu, P., Gudnason, V., O'Donnell, C.J., Rotter, J.I., Tsai, M.Y., Post, W.S., Clarke, R., Söderberg, S., Bossé, Y., Wells, Q.S., Smith, J.G., Rader, D.J., Lathrop, M., Engert, J.C., Thanassoulis, G.. DOI 10.1001/jamacardio.2020.0246

A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and drug candidates for human healthspan extension medRxiv, 2020. Perrot, N., Pelletier, W., Bourgault, J., Couture, C., Li, Z., Mitchell, P., Ghodsian, N., Bossé, Y., Thériault, S., Mathieu, P., Arsenault, B.J.. DOI 10.1101/2020.07.06.20147520

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals Nature Genetics, 2019. Giri, A., Hellwege, J.N., Keaton, J.M., Park, J., Qiu, C., Warren, H.R., Torstenson, E.S., Kovesdy, C.P., Sun, Y.V., Wilson, O.D., Robinson-Cohen, C., Roumie, C.L., Chung, C.P., Birdwell, K.A., Damrauer, S.M., DuVall, S.L., Klarin, D., Cho, K., Wang, Y., Evangelou, E., Cabrera, C.P., Wain, L.V., Shrestha, R., Mautz, B.S., Akwo, E.A., Sargurupremraj, M., Debette, S., Boehnke, M., Scott, L.J., Luan, J., Zhao, J.-H., Willems, S.M., Thériault, S., Shah, N., Oldmeadow, C., Almgren, P., Li-Gao, R., Verweij, N., Boutin, T.S., Mangino, M., Ntalla, I., Feofanova, E., Surendran, P., Cook, J.P., Karthikeyan, S., Lahrouchi, N., Liu, C., Sepúlveda, N., Richardson, T.G., Kraja, A., Amouyel, P., Farrall, M., Poulter, N.R., Laakso, M., Zeggini, E., Sever, P., Scott, R.A., Langenberg, C., Wareham, N.J., Conen, D., Palmer, C.N.A., Attia, J., Chasman, D.I., Ridker, P.M., Melander, O., Mook-Kanamori, D.O., van der Harst, P., Cucca, F., Schlessinger, D., Hayward, C., Spector, T.D., Jarvelin, M.-R., Hennig, B.J., Timpson, N.J., Wei, W.-Q., Smith, J.C., Xu, Y., Matheny, M.E., Siew, E.E., Lindgren, C., Herzig, K.-H., Dedoussis, G., Denny, J.C., Psaty, B.M., Howson, J.M.M., Munroe, P.B., Newton-Cheh, C., Caulfield, M.J., Elliott, P., Gaziano, J.M., Concato, J., Wilson, P.W.F., Tsao, P.S., Velez Edwards, D.R., Susztak, K., O’Donnell, C.J., Hung, A.M., Edwards, T.L.. DOI 10.1038/s41588-018-0303-9

PALMD as a novel target for calcific aortic valve stenosis Current Opinion in Cardiology, 2019. Bossé, Y., Mathieu, P., Thériault, S.. DOI 10.1097/HCO.0000000000000605

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders Nature Human Behaviour, 2019. Evangelou, E., Gao, H., Chu, C., Ntritsos, G., Blakeley, P., Butts, A.R., Pazoki, R., Suzuki, H., Koskeridis, F., Yiorkas, A.M., Karaman, I., Elliott, J., Luo, Q., Aeschbacher, S., Bartz, T.M., Baumeister, S.E., Braund, P.S., Brown, M.R., Brody, J.A., Clarke, T.-K., Dimou, N., Faul, J.D., Homuth, G., Jackson, A.U., Kentistou, K.A., Joshi, P.K., Lemaitre, R.N., Lind, P.A., Lyytikäinen, L.-P., Mangino, M., Milaneschi, Y., Nelson, C.P., Nolte, I.M., Perälä, M.-M., Polasek, O., Porteous, D., Ratliff, S.M., Smith, J.A., Stančáková, A., Teumer, A., Tuominen, S., Thériault, S., Vangipurapu, J., Whitfield, J.B., Wood, A., Yao, J., Yu, B., Zhao, W., Arking, D.E., Auvinen, J., Liu, C., Männikkö, M., Risch, L., Rotter, J.I., Snieder, H., Veijola, J., Blakemore, A.I., Boehnke, M., Campbell, H., Conen, D., Eriksson, J.G., Grabe, H.J., Guo, X., van der Harst, P., Hartman, C.A., Hayward, C., Heath, A.C., Jarvelin, M.-R., Kähönen, M., Kardia, S.L.R., Kühne, M., Kuusisto, J., Laakso, M., Lahti, J., Lehtimäki, T., McIntosh, A.M., Mohlke, K.L., Morrison, A.C., Martin, N.G., Oldehinkel, A.J., Penninx, B.W.J.H., Psaty, B.M., Raitakari, O.T., Rudan, I., Samani, N.J., Scott, L.J., Spector, T.D., Verweij, N., Weir, D.R., Wilson, J.F., Levy, D., Tzoulaki, I., Bell, J.D., Matthews, P.M., Rothenfluh, A., Desrivières, S., Schumann, G., Elliott, P.. DOI 10.1038/s41562-019-0653-z

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction bioRxiv, 2019. Ntalla, I., Weng, L.-C., Cartwright, J.H., Hall, A.W., Sveinbjornsson, G., Tucker, N.R., Choi, S.H., Chaffin, M.D., Roselli, C., Barnes, M.R., Mifsud, B., Warren, H.R., Hayward, C., Marten, J., Cranley, J.J., Concas, M.P., Gasparini, P., Boutin, T., Kolcic, I., Polasek, O., Rudan, I., Araujo, N.M., Lima-Costa, M.F., Ribeiro, A.L.P., Souza, R.P., Tarazona-Santos, E., Giedraitis, V., Ingelsson, E., Mahajan, A., Morris, A.P., Fabiola Del Greco, M., Foco, L., Gögele, M., Hicks, A.A., Cook, J.P., Lind, L., Lindgren, C.M., Sundström, J., Nelson, C.P., Riaz, M.B., Samani, N.J., Sinagra, G., Ulivi, S., Kähönen, M., Mishra, P.P., Mononen, N., Nikus, K., Caulfield, M.J., Dominiczak, A., Padmanabhan, S., Montasser, M.E., O'Connell, J.R., Ryan, K., Shuldiner, A.R., Aeschbacher, S., Conen, D., Risch, L., Thériault, S., Hutri-Kähönen, N., Lehtimäki, T., Lyytikäinen, L.-P., Raitakari, O.T., Barnes, C.L.K., Campbell, H., Joshi, P.K., Wilson, J.F., Isaacs, A., Kors, J.A., van Duijn, C.M., Huang, P.L., Gudnason, V., Harris, T.B., Launer, L.J., Smith, A.V., Bottinger, E.P., Loos, R.J.F., Nadkarni, G.N., Preuss, M.H., Correa, A., Mei, H., Wilson, J., Meitinger, T., Müller-Nurasyid, M., Peters, A., Waldenberger, M., Mangino, M., Spector, T.D., Rienstra, M., van de Vegte, Y.J., van der Harst, P., Verweij, N., Kääb, S., Schramm, K., Sinner, M.F., Strauch, K., Cutler, M.J., Fatkin, D., London, B., Olesen, M., Roden, D.M., Benjamin Shoemaker, M., Gustav Smith, J., Biggs, M.L., Bis, J.C., Brody, J.A., Psaty, B.M., Rice, K., Sotoodehnia, N., de Grandi, A., Fuchsberger, C., Pattaro, C., Pramstaller, P.P., Ford, I., Wouter Jukema, J., Macfarlane, P.W., Trompet, S., Dörr, M., Felix, S.B., Völker, U., Weiss, S., Havulinna, A.S., Jula, A., Sääksjärvi, K., Salomaa, V., Guo, X., Heckbert, S.R., Lin, H.J., Rotter, J.I., Taylor, K.D., Yao, J., de Mutsert, R., Maan, A.C., Mook-Kanamori, D.O., Noordam, R., Cucca, F., Ding, J., Lakatta, E.G., Qian, Y., Tarasov, K.V., Levy, D., Lin, H., Newton-Cheh, C.H., Lunetta, K.L., Murray, A.D., Porteous, D.J., Smith, B.H., Stricker, B.H., Uitterlinden, A., van den Berg, M.E., Haessler, J., Jackson, R.D., Kooperberg, C., Peters, U., Reiner, A.P., Whitsel, E.A., Alonso, A., Arking, D.E., Boerwinkle, E., Ehret, G.B., Soliman, E.Z., Avery, C.L., Gogarten, S.M., Kerr, K.F., Laurie, C.C., Seyerle, A.A., Stilp, A., Assa, S., Abdullah Said, M., Yldau van der Ende, M., Lambiase, P.D., Orini, M., Ramirez, J., van Duijvenboden, S., Arnar, D.O., Gudbjartsson, D.F., Holm, H., Sulem, P., Thorleifsson, G., Thorolfsdottir, R.B., Thorsteinsdottir, U., Benjamin, E.J., Tinker, A., Stefansson, K., Ellinor, P.T., Jamshidi, Y., Lubitz, S.A., Munroe, P.B.. DOI 10.1101/712398

Long-Term Exposure to Elevated Lipoprotein(a) Levels, Parental Lifespan and Risk of Mortality bioRxiv, 2019. Arsenault, B.J., Pelletier, W., Kaiser, Y., Perrot, N., Couture, C., Khaw, K.-T., Wareham, N.J., Bossé, Y., Pibarot, P., Stroes, E.S.G., Mathieu, P., Thériault, S., Boekholdt, S.M.. DOI 10.1101/615898

Long-Term Exposure to Elevated Lipoprotein(A) Levels Influences Human Longevity SSRN, 2019. Arsenault, B., Pelletier, W., Kaiser, Y., Perrot, N., Couture, C., Khaw, K.-T., Wareham, N.J., Bossé, Y., Pibarot, P., Stroes, E.S.G., Mathieu, P., Thériault, S., Boekholdt, S.M.. DOI 10.2139/ssrn.3404259

Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography CJC Open, 2019. Després, A.-A., Perrot, N., Poulin, A., Tastet, L., Shen, M., Chen, H.Y., Bourgeois, R., Trottier, M., Tessier, M., Guimond, J., Nadeau, M., Engert, J.C., Thériault, S., Bossé, Y., Witztum, J.L., Couture, P., Mathieu, P., Dweck, M.R., Tsimikas, S., Thanassoulis, G., Pibarot, P., Clavel, M.-A., Arsenault, B.J.. DOI 10.1016/j.cjco.2019.03.004

Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis bioRxiv, 2019. Perrot, N., Moschetta, D., Boekholdt, S.M., Valerio, V., Martinsson, A., Capoulade, R., Mass, E., Clavel, M.-A., Wareham, N.J., Dina, C., Chen, H.Y., Engert, J.C., Thanassoulis, G., Mathieu, P., Bossé, Y., Pibarot, P., Smith, J.G., Camera, M., Thériault, S., Poggio, P., Arsenault, B.J.. DOI 10.1101/560458

Genetic association analyses highlight IL6, ALPL, and NAV1 as three new susceptibility genes underlying calcific aortic valve stenosis bioRxiv, 2019. Thériault, S., Dina, C., Messika-Zeitoun, D., Le Scouarnec, S., Capoulade, R., Gaudreault, N., Rigade, S., Li, Z., Simonet, F., Lamontagne, M., Clavel, M.-A., Arsenault, B.J., Boureau, A.-S., Lecointe, S., Baron, E., Bonnaud, S., Karakachoff, M., Charpentier, E., Fellah, I., Roussel, J.-C., Verhoye, J.P., Baufreton, C., Probst, V., Roussel, R., Redon, R., Dagenais, F., Pibarot, P., Mathieu, P., Le Tourneau, T., Bossé, Y., Schott, J.-J.. DOI 10.1101/515494

Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification JAMA Cardiology, 2019. Perrot, N., Thériault, S., Dina, C., Chen, H.Y., Boekholdt, S.M., Rigade, S., Després, A.-A., Poulin, A., Capoulade, R., Le Tourneau, T., Messika-Zeitoun, D., Trottier, M., Tessier, M., Guimond, J., Nadeau, M., Engert, J.C., Khaw, K.-T., Wareham, N.J., Dweck, M.R., Mathieu, P., Pibarot, P., Schott, J.-J., Thanassoulis, G., Clavel, M.-A., Bossé, Y., Arsenault, B.J.. DOI 10.1001/jamacardio.2019.1581

Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis Circulation: Genomic and Precision Medicine, 2019. Thériault, S., Dina, C., Messika-Zeitoun, D., Le Scouarnec, S., Capoulade, R., Gaudreault, N., Rigade, S., Li, Z., Simonet, F., Lamontagne, M., Clavel, M.-A., Arsenault, B.J., Boureau, A.-S., Lecointe, S., Baron, E., Bonnaud, S., Karakachoff, M., Charpentier, E., Fellah, I., Roussel, J.-C., Philippe Verhoye, J., Baufreton, C., Probst, V., Roussel, R., Redon, R., Dagenais, F., Pibarot, P., Mathieu, P., Le Tourneau, T., Bossé, Y., Schott, J.-J., Thériault, S., Dina, C., Messika-Zeitoun, D., Le Scouarnec, S., Capoulade, R., Gaudreault, N., Rigade, S., Li, Z., Simonet, F., Lamontagne, M., Clavel, M.-A., Arsenault, B.J., Boureau, A.-S., Lecointe, S., Baron, E., Bonnaud, S., Karakachoff, M., Charpentier, E., Fellah, I., Roussel, J.-C., Philippe Verhoye, J., Baufreton, C., Probst, V., Roussel, R., Dagenais, F., Pibarot, P., Mathieu, P., Le Tourneau, T., Bossé, Y., Schott, J.-J., Balkau, B., Ducimetière, P., Eschwège, E., Alhenc-Gelas, F., Girault, A., Fumeron, F., Marre, M., Bonnet, F., Bonnefond, A., Froguel, P., Rancière, F., Cogneau, J., Born, C., Caces, E., Cailleau, M., Lantieri, O., Moreau, J.G., Rakotozafy, F., Tichet, J., Vol, S.. DOI 10.1161/CIRCGEN.119.002617

A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity npj Genomic Medicine, 2019. Rosa, M., Chignon, A., Li, Z., Boulanger, M.-C., Arsenault, B.J., Bossé, Y., Thériault, S., Mathieu, P.. DOI 10.1038/s41525-019-0097-4