Répertoire du corps professoral

Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université du Québec à Montréal - UQAM
Du 1 avril 2024 au31 mars 2030

Repousser les frontières de l'étude de la biologie à l'échelle nanométrique en conditions naturelles
Programme: Fonds d'innovation (FI)
Organisme(s) subventionnaire(s): Fondation Canadienne pour l'innovation (La), CIUSSS-CN CERVO, Ministère de la Santé et des Services sociaux
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2023 au31 mars 2025

Canada Research Chair in Synthetic Biology and Systems Biomedicine
Programme: Chaires de recherche du Canada - Fonctionnement
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mai 2023 au29 avril 2028

The role of conformational dynamics in viral fusion proteins epitopes presentation and recognition for antibody engineering applications
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au31 mars 2028

Chaire de Recherche du Canada en Biologie Synthétique et Biomédecine des Systèmes
Programme: Fonds des leaders John-R.-Evans (FLJR)
Organisme(s) subventionnaire(s): Ministère de l'Économie et de l'Innovation, Fondation Canadienne pour l'innovation (La)
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au31 décembre 2024

Financements des 2 dernières années

Forum des nouveaux chercheurs de l'IMII des IRSC
Programme: Forum des nouveaux chercheurs de LIMII des IRSC
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2024 au31 mars 2024

The role of conformational dynamics in viral fusion proteins epitopes presentation and recognition for antibody engineering applications
Programme: Supplément Tremplin vers la découverte
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au31 mars 2024

Cryo-TEM infrastructure for the visualisation of nanoparticles, exosomes and virus-like particles
Programme: Subventions d'outils et d'instruments de recherche (OIR)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 31 mars 2023 au31 mars 2024

Sabrina Gentil, Doctorat en biochimie

Publications des 5 dernières années

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike 2022/04/08. Victoria Stalls, Jared Lindenberger, Sophie M-C. Gobeil, Rory Henderson, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Bryan Kraft, Xiaozhi Lu, Robert J Edwards, Amanda Eaton, David C. Montefiori, Wilton Williams, Kevin O. Saunders, Kevin Wiehe, Barton F. Haynes, Priyamvada Acharya. DOI 10.1101/2022.04.07.487528

Structural diversity of the SARS-CoV-2 Omicron spike 2022/01/26. Sophie M-C. Gobeil, Rory Henderson, Victoria Stalls, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Kartik Manne, Dapeng Li, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katayoun Mansouri, Robert J. Edwards, Gregory D. Sempowski, Kevin O. Saunders, Kevin Wiehe, Wilton Williams, Bette Korber, Barton F. Haynes, Priyamvada Acharya. DOI 10.1101/2022.01.25.477784

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice Science Translational Medicine, 2022/01/26. David R. Martinez, Alexandra Schäfer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, Maggie Barr, Victoria Stalls, Katarzyna Janowska, Esther Beaudoin, Kartik Manne, Katayoun Mansouri, Robert J. Edwards, Kenneth Cronin, Boyd Yount, Kara Anasti, Stephanie A. Montgomery, Juanjie Tang, Hana Golding, Shaunna Shen, Tongqing Zhou, Peter D. Kwong, Barney S. Graham, John R. Mascola, David C. Montefiori, S. Munir Alam, Gregory D. Sempowski, Surender Khurana, Kevin Wiehe, Kevin O. Saunders, Priyamvada Acharya, Barton F. Haynes, Ralph S. Baric. DOI 10.1126/scitranslmed.abj7125

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity Science, 2021/08/06. Sophie M.-C. Gobeil, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Victoria Stalls, Megan F. Kopp, Kartik Manne, Dapeng Li, Kevin Wiehe, Kevin O. Saunders, Robert J. Edwards, Bette Korber, Barton F. Haynes, Rory Henderson, Priyamvada Acharya. DOI 10.1126/science.abi6226

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses Nature, 2021/06/24. Kevin O. Saunders, Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, Sophie Gobeil, Maggie Barr, Katayoun Mansouri, S. Munir Alam, Laura L. Sutherland, Fangping Cai, Aja M. Sanzone, Madison Berry, Kartik Manne, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Anyway B. Kapingidza, Mihai Azoitei, Longping V. Tse, Trevor D. Scobey, Rachel L. Spreng, R. Wes Rountree, C. Todd DeMarco, Thomas N. Denny, Christopher W. Woods, Elizabeth W. Petzold, Juanjie Tang, Thomas H. Oguin, III, Gregory D. Sempowski, Matthew Gagne, Daniel C. Douek, Mark A. Tomai, Christopher B. Fox, Robert Seder, Kevin Wiehe, Drew Weissman, Norbert Pardi, Hana Golding, Surender Khurana, Priyamvada Acharya, Hanne Andersen, Mark G. Lewis, Ian N. Moore, David C. Montefiori, Ralph S. Baric, Barton F. Haynes. DOI 10.1038/s41586-021-03594-0

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice 2021/04/28. David R. Martinez, Alexandra Schaefer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, Maggie Barr, Kartik Manne, Katayoun Mansouri, Robert J. Edwards, Boyd Yount, Kara Anasti, Stephanie A. Montgomery, Shaunna Shen, Tongqing Zhou, Peter D. Kwong, Barney S. Graham, John R. Mascola, David. C. Montefiori, Munir Alam, Gregory D. Sempowski, Kevin Wiehe, Kevin O. Saunders, Priyamvada Acharya, Barton F. Haynes, Ralph S. Baric. DOI 10.1101/2021.04.27.441655

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity 2021/03/12. Sophie M-C. Gobeil, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Victoria Stalls, Megan F. Kopp, Kartik Manne, Kevin Saunders, Robert J Edwards, Barton F. Haynes, Rory C. Henderson, Priyamvada Acharya. DOI 10.1101/2021.03.11.435037

SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys 2021/02/17. Kevin O. Saunders, Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, Sophie Gobeil, Maggie Barr, Katayoun Mansouri, S. Munir Alam, Laura L. Sutherland, Fangping Cai, Aja M. Sanzone, Madison Berry, Kartik Manne, Anyway B. Kapingidza, Mihai Azoitei, Longping V. Tse, Trevor D. Scobey, Rachel L. Spreng, R. Wes Rountree, C. Todd DeMarco, Thomas N. Denny, Christopher W. Woods, Elizabeth W. Petzold, Thomas H. Oguin, III, Gregory D. Sempowski, Matthew Gagne, Daniel C. Douek, Mark A. Tomai, Christopher B. Fox, Robert Seder, Kevin Wiehe, Drew Weissman, Norbert Pardi, Priyamvada Acharya, Hanne Andersen, Mark G. Lewis, Ian N. Moore, David C. Montefiori, Ralph S. Baric, Barton F. Haynes. DOI 10.1101/2021.02.17.431492

Cold sensitivity of the SARS-CoV-2 spike ectodomain Nature Structural & Molecular Biology, 2021/02/05. Robert J. Edwards, Katayoun Mansouri, Victoria Stalls, Kartik Manne, Brian Watts, Rob Parks, Katarzyna Janowska, Sophie M. C. Gobeil, Megan Kopp, Dapeng Li, Xiaozhi Lu, Zekun Mu, Margaret Deyton, Thomas H. Oguin, III, Jordan Sprenz, Wilton Williams, Kevin O. Saunders, David Montefiori, Gregory D. Sempowski, Rory Henderson, S. Munir Alam, Barton F. Haynes, Priyamvada Acharya. DOI 10.1038/s41594-020-00547-5

Controlling the SARS-CoV-2 spike glycoprotein conformation Nature Structural & Molecular Biology, 2020/10/22. Rory Henderson, Robert J. Edwards, Katayoun Mansouri, Katarzyna Janowska, Victoria Stalls, Sophie M. C. Gobeil, Megan Kopp, Dapeng Li, Rob Parks, Allen L. Hsu, Mario J. Borgnia, Barton F. Haynes, Priyamvada Acharya. DOI 10.1038/s41594-020-0479-4

D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction 2020/10/12. Sophie M-C. Gobeil, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Kartik Manne, Victoria Stalls, Megan Kopp, Rory Henderson, Robert J Edwards, Barton F. Haynes, Priyamvada Acharya. DOI 10.1101/2020.10.11.335299

Cold sensitivity of the SARS-CoV-2 spike ectodomain [], 2020/07/13. DOI 10.1101/2020.07.12.199588

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation 2020/05/18. Rory Henderson, Robert J Edwards, Katayoun Mansouri, Katarzyna Janowska, Victoria Stalls, Sophie Gobeil, Megan Kopp, Allen Hsu, Mario Borgnia, Rob Parks, Barton F. Haynes, Priyamvada Acharya. DOI 10.1101/2020.05.18.102087

Leveraging Fungal Calcineurin-Inhibitor Structures, Biophysics and Dynamics to Design Selective and Non-Immunosuppressive FK506 Analogs 2020/04/15. Sophie M.-C. Gobeil, Benjamin G. Bobay, Praveen R. Juvvadi, D. Christopher Cole, Joseph Heitman, William J. Steinbach, Ronald A. Venters, Leonard D. Spicer. DOI 10.1101/2020.04.14.039800

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents Nature Communications, 2019/09/19. Praveen R. Juvvadi, David Fox, III, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach. DOI 10.1038/s41467-019-12199-1

The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function Scientific Reports, 2019/04/30. Sophie M. C. Gobeil, Maximillian C. C. J. C. Ebert, Jaeok Park, Donald Gagné, Nicolas Doucet, Albert M. Berghuis, Jürgen Pleiss, Joelle N. Pelletier. DOI 10.1038/s41598-019-42866-8

15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus Biomolecular NMR Assignments, 2019/04/01. Sophie M. C. Gobeil, Benjamin G. Bobay, Leonard D. Spicer, Ronald A. Venters. DOI 10.1007/s12104-019-09878-x