Répertoire du corps professoral

Metabolic mechanisms of pro-resolutive neutrophils in chronic inflammatory diseases
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2024 au 31 mars 2029

Role of phosphatidylserine-specific phospholipase A1 (PLA1A) in the pathogenesis of rheumatic diseases
Programme: Subvention stratégique de fonctionnement
Organisme(s) subventionnaire(s): Société de l'arthrite du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 janvier 2023 au 31 décembre 2025

Financements des 2 dernières années

Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis.
Programme: Subvention de fonctionnement
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2015 au 31 mars 2023

Encadrements terminés dans les 5 dernières années

Stephan Hasse, Doctorat en microbiologie-immunologie

Yang Zhao, Doctorat en microbiologie-immunologie

Jouda Gamara, Doctorat en microbiologie-immunologie

Lisa Auclert, Maîtrise sur mesure - avec mémoire (M. Sc.)

Publications des 5 dernières années

Metabolic regulation of neutrophil functions in homeostasis and diseases Journal of Leukocyte Biology, 2024/09/02. Pier-Olivier Leblanc, Sylvain G Bourgoin, Patrice E Poubelle, Philippe A Tessier, Martin Pelletier. DOI 10.1093/jleuko/qiae025

Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis Cells, 2022/12/24. François C. Chouinard, Lynn Davis, Caroline Gilbert, Sylvain G. Bourgoin. DOI 10.3390/cells12010072

Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model International Journal of Molecular Sciences, 2022/08/02. Yang Zhao, Fawzi Aoudjit, Sylvain G. Bourgoin. DOI 10.3390/ijms23158559

Red blood cell-derived phosphatidylserine positive extracellular vesicles are associated with past thrombotic events in patients with systemic erythematous lupus Lupus Science & Medicine, 2022/03. Stephan Hasse, Anne-Sophie Julien, Anne-Claire Duchez, Chenqi Zhao, Eric Boilard, Paul R Fortin, Sylvain G Bourgoin. DOI 10.1136/lupus-2021-000605

Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Blood, 2021/12/23. Genevieve Marcoux, Audrée Laroche, Stephan Hasse, Marie Bellio, Maroua Mbarik, Marie Tamagne, Isabelle Allaeys, Anne Zufferey, Tania Lévesque, Johan Rebetz, Annie Karakeussian Rimbaud, Julie Turgeon, Sylvain Bourgoin, HAMZEH-COGNASSE, Fabrice Cognasse, Rick Kapur, John Semple, Marie-Josée Hébert, France Pirenne, Herman S. Overkleeft, Bogdan Iulius Florea, Mélanie Dieudé, Benoît Vingert, Eric Boilard. DOI 10.1182/blood.2020009957

Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis International Journal of Molecular Sciences, 2021/11/24. Sylvain Bourgoin, Yang Zhao, Stephan Hasse, Myriam Vaillancourt, Chenqi Zhao, Lynn Davis, Eric Boilard, Paul Fortin, John Di Battista, Patrice E. Poubelle, Sylvain G. Bourgoin. DOI 10.3390/ijms222312685

Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes Biochemical Pharmacology, 2021/10. Sylvain Bourgoin, Stephan Hasse, Anne-Claire Duchez, Paul Fortin, Eric Boilard, Sylvain G. Bourgoin. DOI 10.1016/j.bcp.2021.114667

Arf6 regulates energy metabolism in neutrophils Free Radical Biology and Medicine, 2021/08. Jouda Gamara, Lynn Davis, Andrew Z. Leong, Nathalie Pagé, Emmanuelle Rollet-Labelle, Chenqi Zhao, Tsunaki Hongu, Yuji Funakoshi, Yasunori Kanaho, Fawzi Aoudji, Martin Pelletier, Sylvain Bourgoin. DOI 10.1016/j.freeradbiomed.2021.07.001

Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise Progress in Lipid Research, 2021/07. Sylvain Bourgoin, Yang Zhao, Stephan Hasse, Sylvain G. Bourgoin. DOI 10.1016/j.plipres.2021.101112

Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β The Journal of Immunology, 2021/04/15. Isabelle Allaeys, Flavia Ribeiro de Vargas, Sylvain G. Bourgoin, Patrice E. Poubelle. DOI 10.4049/jimmunol.2000852

Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration Mediators of Inflammation, 2020/04/07. Jouda Gamara, Lynn Davis, Emmanuelle Rollet-Labelle, Tsunaki Hongu, Yuji Funakoshi, Yasunori Kanaho, Fawzi Aoudjit, Sylvain G. Bourgoin. DOI 10.1155/2020/2713074

Phospholipase D2 in prostate cancer: protein expression changes with Gleason score British Journal of Cancer, 2019/12/10. Sylvain Bourgoin, Amanda R. Noble, Karen Hogg, Rakesh Suman, Daniel M. Berney, Sylvain Bourgoin, Norman J. Maitland, Martin G. Rumsby. DOI 10.1038/s41416-019-0610-7

Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion? Biochemical Pharmacology, 2019/07. Chenqi Zhao, Nathalie Amiable, Melissa Laflamme, David Marsolais, John A. Di Battista, Maria J. Fernandes, Sylvain G. Bourgoin. DOI 10.1016/j.bcp.2019.02.009

Targeting the autotaxin – Lysophosphatidic acid receptor axis in cardiovascular diseases Biochemical Pharmacology, 2019/06. Yang Zhao, Stephan Hasse, Chenqi Zhao, Sylvain G. Bourgoin. DOI 10.1016/j.bcp.2019.03.035