Répertoire du corps professoral

The Ribosomal RNA Genes in Growth, Pluripotency, Senescence and Cancer
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2024 au 28 février 2025

Mechanism of Ribosomal RNA Gene Silencing and Its Roles in Pluripotency and Cancer
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2017 au 31 mars 2025

Financements des 2 dernières années

Pathobiology and treatment of the UBTF E210K neuroregression syndrome
Programme: Subvention de recherche
Organisme(s) subventionnaire(s): National Institute of Health (USA)
Type de financement: Subvention
Établissement tête: University of Memphis
Du 1 juillet 2021 au 30 août 2023

Role of Misshappen (NIK/Msn) kinases and Extended-Synaptotagmins (E-Syts) in Wnt and FGF intracellular signaling pathways.
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2017 au 31 mars 2023

Encadrements terminés dans les 5 dernières années

Dany Sibai, Doctorat en biologie cellulaire et moléculaire

Jean-Clement Mars, Doctorat en biologie cellulaire et moléculaire

Chelsea Herdman, Maîtrise en biologie cellulaire et moléculaire - avec mémoire

Chelsea Herdman, Doctorat en biologie cellulaire et moléculaire

Prakash Kumar Mishra, Doctorat en biologie cellulaire et moléculaire

Abdelatif Nourdine Hamdane, Doctorat en biologie cellulaire et moléculaire

Publications des 5 dernières années

TTF1 control of LncRNA synthesis delineates a tumor suppressor pathway directly regulating the ribosomal RNA genes Journal of Cellular Physiology, 2024/08. Dany S. Sibai, Michel G. Tremblay, Frédéric Lessard, Christophe Tav, Marianne Sabourin‐Félix, Mark Robinson, Tom Moss. DOI 10.1002/jcp.31303

TTF1 control of LncRNA synthesis and cell growth delineates a tumour suppressor pathway acting directly on the ribosomal RNA Genes 2024/02/11. Dany S. Sibai, Michel G. Tremblay, Frédéric Lessard, Christophe Tav, Marianne Sabourin-Félix, Mark D. Robinson, Tom Moss. DOI 10.1101/2024.02.11.579707

Transcription factor UBF depletion in mouse cells results in downregulation of both downstream and upstream elements of the rRNA transcription network. The Journal of biological chemistry, 2023/09/01. Theophanous A, Christodoulou A, Mattheou C, Dany Sibai, Moss T, Santama N. DOI 10.1016/j.jbc.2023.105203

HMG-boxes, ribosomopathies and neurodegenerative disease. Frontiers in genetics, 2023/08/03. Moss T, LeDoux MS, Crane-Robinson C. DOI 10.3389/fgene.2023.1225832

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans Life science alliance, 2022/09. Daiß J, Pilsl M, Straub K, Bleckmann A, Höcherl M, Heiss F, Abascal-Palacios G, Ramsay E, Tlučková K, Mars J, Fürtges T, Bruckmann A, Rudack T, Engel C.

Control of ribosomal RNA synthesis by hematopoietic transcription factors. Molecular cell, 2022/09. Antony C, George SS, Blum J, Somers P, Thorsheim CL, Wu-Corts DJ, Ai Y, Gao L, Lv K, Tremblay MG, Moss T, Tan K, Wilusz JE, Ganley ARD, Pimkin M, Paralkar VR. DOI 10.1016/j.molcel.2022.08.027

Behavioral and molecular effects of Ubtf knockout and knockdown in mice. Brain research, 2022/08. Hori RT, Moshahid Khan M, Xiao J, Hargrove PW, Moss T, LeDoux MS. DOI 10.1016/j.brainres.2022.148053

Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome PLOS Genetics, 2022/02/09. Michel G. Tremblay, Dany S. Sibai, Melissa Valère, Jean-Clément Mars, Frédéric Lessard, Roderick T. Hori, Mohammad Moshahid Khan, Victor Y. Stefanovsky, Mark S. LeDoux, Tom Moss. DOI 10.1371/journal.pgen.1009644

Bidirectional cooperation between Ubtf1 and SL1 determines RNA Polymerase I promoter recognition in cell and is negatively affected in the UBTF-E210K neuroregression syndrome 2021/06/07. Michel G. Tremblay, Dany S. Sibai, Melissa Valère, Jean-Clément Mars, Frédéric Lessard, Roderick T. Hori, Mohammad M. Khan, Victor Y. Stefanovsky, Mark S. Ledoux, Tom Moss. DOI 10.1101/2021.06.07.447350

The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability NAR Cancer, 2020/11/06. Jean-Clément Mars, Michel G Tremblay, Mélissa Valere, Dany S Sibai, Marianne Sabourin-Felix, Frédéric Lessard, Tom Moss. DOI 10.1093/narcan/zcaa032

The Short N-Terminal Repeats of Transcription Termination Factor 1 Contain Semi-Redundant Nucleolar Localization Signals and P19-ARF Tumor Suppressor Binding Sites. The Yale journal of biology and medicine, 2019/09/20.

The chromatin landscape of the ribosomal RNA genes in mouse and human Chromosome Research, 2019/03/08. Tom Moss, Jean-Clement Mars, Michel G. Tremblay, Marianne Sabourin-Felix. DOI 10.1007/s10577-018-09603-9