Répertoire du corps professoral

Molecular and Genetic Epidemiology to Understand Mitral Valve Prolapse
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2024 au 31 mars 2029

Sex and sex-hormones determine pulmonary morphological and single-nucleus transcriptomic responses in an animal model of sleep apnea.
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2024 au 28 février 2025

Différentiation sexuelle des réponses pulmonaires par séquençage d’ARN en cellules uniques
Organisme(s) subventionnaire(s): Fondation J.-D.-Bégin
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 janvier 2023 au 31 décembre 2024

Programme VISION
Programme: Tremplin
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 novembre 2022 au 31 mars 2026

Air pollution, climate and COPD: acute and long-term impacts in Canadian populations
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université McGill
Du 1 avril 2021 au 31 mars 2025

Canada Research Chair in Genomics of Heart and Lung Diseases
Programme: Chaires de recherche du Canada - Fonctionnement
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2020 au 30 juin 2025

Financements des 2 dernières années

Blood Epigenetic Age Biomarkers and Health Outcomes in COPD
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: University of British Columbia
Du 1 octobre 2022 au 31 mars 2023

Analyse statistique des liens entre blocs de variables de format mixte. Applications en épidémiologie, génomique et sécurité sanitaire.
Programme: Programme Samuel-De Champlain
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022 au 31 mars 2024

Linking clinical, research and imaging data in lung cancer: towards FAIR and AI-ready datasets
Programme: Subventions de transformation de données sur le cancer
Organisme(s) subventionnaire(s): Société canadienne du cancer
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 mars 2022 au 14 mars 2023

A transcriptome- and proteome-wide association study of non-alcoholic fatty liver disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2021 au 30 septembre 2024

A genome-wide association study of dysanapsis
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université McGill
Du 1 avril 2020 au 31 mars 2023

Deciphering the role of PTPN6/SHP-1 and its mutant PTPN6/SHP-1Ala455Thr in the development of pulmonary emphysema
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2019 au 30 septembre 2024

Elucidating the role of lipoprotein(a) in calcific aortic valve stenosis using novel proteomic and imaging approaches
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2019 au 30 septembre 2023

Identification of novel therapeutic targets for calcific aortic valve stenosis using integrative genomics
Programme: Subventions de recherche
Organisme(s) subventionnaire(s): Fondation des maladies du coeur et de l'AVC du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2019 au 31 juillet 2023

Integrative genomics and functional analyses to uncover the molecular mechanisms involved in bicuspid aortic valve disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2019 au 31 mars 2024

Finding the molecular drivers of calcific aortic valve stenosis
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2018 au 31 mars 2023

Functional and clinical characterization of PALMD calcific aortic valve stenosis risk locus
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2018 au 31 mars 2023

Genomic predictors of smoking and lung cancer risk
Programme: Subvention de recherche
Organisme(s) subventionnaire(s): National Institute of Health (USA)
Type de financement: Subvention
Établissement tête: Geisel School of Medicine at Dartmouth
Du 1 août 2017 au 31 mars 2024

Ran Xu, Doctorat en médecine moléculaire

Samuel Mathieu, Maîtrise en médecine moléculaire - avec mémoire

Veronique Boumtje, Doctorat en médecine moléculaire

Mozart Nerva Deneus, Maîtrise en épidémiologie - avec mémoire

Encadrements terminés dans les 5 dernières années

Alisson Clemenceau, Maîtrise en médecine moléculaire - avec mémoire

Alisson Clemenceau, Doctorat en médecine moléculaire

Sandra Milena Guauque, Doctorat en biologie cellulaire et moléculaire

Nicolas Perrot, Doctorat en médecine moléculaire

Louis-Jacques Ruel, Maîtrise en médecine moléculaire - avec mémoire

Jean-Christophe Bérubé, Maîtrise en médecine expérimentale - avec mémoire

Maxime Lamontagne, Maîtrise en médecine expérimentale - avec mémoire

Maxime Lamontagne, Doctorat en médecine expérimentale

Publications des 5 dernières années

Circulating Autoantibodies Targeting TREK-1 in Patients With Short-Coupled Ventricular Fibrillation Circulation, 2024/09/24. Jin Li, Alexandre Janin, Mona Patoughi, Nathalie Gaudreault, Lenke Kis, Hamid Moha Ou Maati, Yohan Bossé, Christian Steinberg. DOI 10.1161/CIRCULATIONAHA.124.070284

Metabolomic Profiling of Pulmonary Neuroendocrine Neoplasms Cancers, 2024/09/17. Clémence Boullier, Fabien C. Lamaze, Jean-François Haince, Rashid Ahmed Bux, Michèle Orain, Jiamin Zheng, Lun Zhang, David S. Wishart, Yohan Bossé, Venkata S. K. Manem, Philippe Joubert. DOI 10.3390/cancers16183179

Efficient molecular mendelian randomization screens with LaScaMolMR.jl 2024/08/30. Samuel Mathieu, Louis-Hippolyte Minvielle Moncla, Mewen Briend, Valentine Duclos, Anne Rufiange, Yohan Bossé, Patrick Mathieu. DOI 10.1101/2024.08.29.24312805

Prognostic implication of methylation-based circulating tumor DNA detection prior to surgery in stage I non-small cell lung cancer Cancer Letters, 2024/07. Yohan Bossé, Abhijit Dasgupta, Michael Abadier, Violeta Guthrie, Florian Song, Victoria Saavedra Armero, Nathalie Gaudreault, Michèle Orain, Fabien C. Lamaze, Collin Melton, Tracy Nance, Tiffany Hung, Darren Hodgson, Chris Abbosh, Philippe Joubert. DOI 10.1016/j.canlet.2024.216984

Lung Tissue Transcriptomics Reveal Associations between Thymic Stromal Lymphopoietin Signaling, Mast Cells, and Airway Obstruction in Active Smokers American Journal of Respiratory Cell and Molecular Biology, 2024/07. Nadia Milad, Sophie Aubin, Christine Racine, François Maltais, Yohan Bossé, Mathieu C. Morissette. DOI 10.1165/rcmb.2023-0416LE

Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse Communications Medicine, 2024/06/06. Louis-Hippolyte Minvielle Moncla, Mewen Briend, Mame Sokhna Sylla, Samuel Mathieu, Anne Rufiange, Yohan Bossé, Patrick Mathieu. DOI 10.1038/s43856-024-00530-x

A Test to Comprehensively Capture the Known Genetic Component of Familial Pulmonary Fibrosis American Journal of Respiratory Cell and Molecular Biology, 2024/06. Judith Villeneuve, Élody Tremblay, Nathalie Gaudreault, Victoria Saavedra Armero, Dominique K. Boudreau, Zhonglin Li, Sébastien Renaut, Geneviève Dion, Yohan Bossé. DOI 10.1165/rcmb.2024-0009MA

Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights PLOS Genetics, 2024/05/30. Sébastien Renaut, Victoria Saavedra Armero, Dominique K. Boudreau, Nathalie Gaudreault, Patrice Desmeules, Sébastien Thériault, Patrick Mathieu, Philippe Joubert, Yohan Bossé. DOI 10.1371/journal.pgen.1011301

Cardiac reverse remodeling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle American Journal of Physiology-Heart and Circulatory Physiology, 2024/04/01. Mohamed Lamine Aidara, Élisabeth Walsh-Wilkinson, Sara-Ève Thibodeau, Emylie-Ann Labbé, Audrey Morin-Grandmont, Geneviève Gagnon, Dominique K. Boudreau, Marie Arsenault, Yohan Bossé, Jacques Couët. DOI 10.1152/ajpheart.00462.2023

Calcific aortic valve disease: mechanisms, prevention and treatment Nature Reviews Cardiology, 2023/08. Louis-Hippolyte Minvielle Moncla, Mewen Briend, Yohan Bossé, Patrick Mathieu. DOI 10.1038/s41569-023-00845-7

Integrative Analysis of the Blood Proteome by Mendelian Randomization Reveals Regulatory Networks in Calcific Aortic Valve Disease 2023/07/28. Mewen Briend, Louis-Hippolyte Minvielle Moncla, Valentine Duclos, Samuel Mathieu, Anne Rufiange, Sébastien Thériault, Benoit Arsenault, Yohan Bossé, Patrick Mathieu. DOI 10.1101/2023.07.26.23293222

A Simplified Version of the IASLC Grading System for Invasive Pulmonary Adenocarcinomas With Improved Prognosis Discrimination American Journal of Surgical Pathology, 2023/06. Yohan Bossé, Andréanne Gagné, Wajd A. Althakfi, Michèle Orain, Christian Couture, Sylvain Trahan, Sylvain Pagé, David Joubert, Pierre O. Fiset, Patrice Desmeules, Philippe Joubert. DOI 10.1097/PAS.0000000000002040

The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis European Heart Journal, 2023/06/01. Sébastien Thériault, Patrick Mathieu, Yohan Bossé. DOI 10.1093/eurheartj/ehad134

Leucocyte-Derived Micro-RNAs as Candidate Biomarkers in Brugada Syndrome 2023/05/25. Christian Steinberg, Alan Spatz, François Philippon, Yohan Bossé. DOI 10.1093/europace/euad145

Prognostic value of complex glandular patterns in invasive pulmonary adenocarcinomas Human Pathology, 2022/10. Yohan Bossé, Andréanne Gagné, Wajd Althakfi, Michèle Orain, Pierre Olivier Fiset, Patrice Desmeules, Philippe Joubert. DOI 10.1016/j.humpath.2022.07.007

The Null Q0Ourém Variant within a Copy-Neutral Loss-of-Heterozygosity Event Causing Alpha-1 Antitrypsin Deficiency American Journal of Respiratory Cell and Molecular Biology, 2022/06. Nathalie Gaudreault, Claudia Blouin, Annie Haillot, Julie Milot, François Maltais, Yohan Bossé. DOI 10.1165/rcmb.2021-0564LE

Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve PLOS Genetics, 2022/01/18. Arnaud Chignon, Déborah Argaud, Marie-Chloé Boulanger, Ghada Mkannez, Valentin Bon-Baret, Zhonglin Li, Sébastien Thériault, Yohan Bossé, Patrick Mathieu. DOI 10.1371/journal.pgen.1010010

Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men Circulation: Genomic and Precision Medicine, 2021/12. Hasanga D. Manikpurage, Aida Eslami, Nicolas Perrot, Zhonglin Li, Christian Couture, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault. DOI 10.1161/CIRCGEN.121.003452

SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues International Journal of Molecular Sciences, 2021/08/26. Guoshuai Cai, Mulong Du, Yohan Bossé, Helmut Albrecht, Fei Qin, Xizhi Luo, Xiao Michelle Androulakis, Chao Cheng, Mitzi Nagarkatti, Prakash Nagarkatti, David C. Christiani, Michael L. Whitfield, Christopher I. Amos, Feifei Xiao. DOI 10.3390/ijms22179228

Sex-Specific Associations of Genetically-Predicted Circulating Lipoprotein(a) and Hepatic LPA Gene Expression Levels with Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses Circulation: Genomic and Precision Medicine, 2021/07/19. Jakie Guertin, Yannick Kaiser, Hasanga Manikpurage, Nicolas Perrot, Raphaëlle Bourgeois, Christian Couture, Nicholas J. Wareham, Yohan Bossé, Philippe Pibarot, Erik S.G. Stroes, Patrick Mathieu, Marie-Annick Clavel, Sébastien Thériault, S. Matthijs Boekholdt, Benoit J. Arsenault. DOI 10.1161/CIRCGEN.120.003271

Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk 2021/07/13. Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bossé, James McKay, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig Bojesen, Maria Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, Erich Wichmann, David Christiani, Gad Rennert, Susanne Arnold, Gary Goodman, John Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Rayjean Hung, Angeline Andrew, Lambertus Kiemeney, Hongbing Shen, Ryan Sun, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Dawn Teare, Yun-Chul Hong, Michael Davies, Philip Lazarus, Matthew Schabath, Melinda Aldrich, Ann Schwartz, Ivan Gorlov, Kristen Purrington, Ping Yang, Younghun Han, Joan Bailey-Wilson, Yanhong Liu, Susan Pinney, Diptasri Mandal, James Willey, Colette Gaba, Paul Brennan, Christopher Amos. DOI 10.21203/rs.3.rs-647012/v1

A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men 2021/04/27. Hasanga D. Manikpurage, Aida Eslami, Nicolas Perrot, Zhonglin Li, Christian Couture, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault. DOI 10.1101/2021.04.25.21256083

System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan Circulation: Genomic and Precision Medicine, 2021/04. Valentin Bon-Baret, Arnaud Chignon, Marie-Chloé Boulanger, Zhonglin Li, Deborah Argaud, Benoit J. Arsenault, Sébastien Thériault, Yohan Bossé, Patrick Mathieu. DOI 10.1161/CIRCGEN.120.003196

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers PLOS Genetics, 2021/03/05. Corina Lesseur, Aida Ferreiro-Iglesias, James D. McKay, Yohan Bossé, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C. Christiani, Neil C. Caporaso, Stig E. Bojesen, Christopher I. Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K. Field, Marion Dawn Teare, Lambertus A. Kiemeney, Brenda Diergaarde, Robert L. Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F. Olshan, Mark C. Weissler, Martin Lacko, Angela Risch, Heike Bickeböller, Andy R. Ness, Steve Thomas, Loic Le Marchand, Matthew B. Schabath, Victor Wünsch-Filho, Eloiza H. Tajara, Angeline S. Andrew, Gary M. Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnström, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma’en Obeidat, Xiangjun Xiao, Richard S. Houlston, Rayjean J. Hung, Paul Brennan. DOI 10.1371/journal.pgen.1009254

Oxyphospholipids in Cardiovascular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology, 2021/01. Arnaud Chignon, Valentin Bon-Baret, Marie-Chloé Boulanger, Yohan Bossé, Patrick Mathieu. DOI 10.1161/ATVBAHA.120.313790

Electronic Health Record-Based Genome-Wide Meta-Analysis and Mendelian Randomization Identify Metabolic and Phenotypic Consequences of Non-Alcoholic Fatty Liver Disease 2020/11/04. Nooshin Ghodsian, Erik Abner, Émilie Gobeil, Nele Taba, Alexis St-Amand, Nicolas Perrot, Christian Couture, Patricia Mitchell, Yohan Bossé, Patrick Mathieu, Marie-Claude Vohl, Sébastien Thériault, André Tchernof, Tõnu Esko, Benoit Arsenault. DOI 10.21203/rs.3.rs-97977/v1

Granularity ofSERPINA1alleles by DNA sequencing in CanCOLD European Respiratory Journal, 2020/10. Nisha Gupta, Nathalie Gaudreault, Sébastien Thériault, Pei Zhi Li, Cyndi Henry, Miranda Kirby, François Maltais, Wan Tan, Jean Bourbeau, Yohan Bossé. DOI 10.1183/13993003.00958-2020

Transcriptomic data helps refining classification of pulmonary carcinoid tumors with increased mitotic counts Modern Pathology, 2020/09. Olga Sazonova, Venkata Manem, Michèle Orain, Babak Khoshkrood-Mansoori, Nathalie Gaudreault, Patrice Desmeules, Yohan Bossé, Philippe Joubert. DOI 10.1038/s41379-020-0538-8

Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis Communications Biology, 2020/08/28. Zhonglin Li, Nathalie Gaudreault, Benoit J. Arsenault, Patrick Mathieu, Yohan Bossé, Sébastien Thériault. DOI 10.1038/s42003-020-01210-x

Reply to Polverino: Cigarette Smoking and COVID-19: A Complex Interaction American Journal of Respiratory and Critical Care Medicine, 2020/08/01. Guoshuai Cai, Yohan Bossé, Feifei Xiao, Farrah Kheradmand, Christopher I. Amos. DOI 10.1164/rccm.202005-1807LE

A Trans-Omic Mendelian Randomization Study of Parental Lifespan Uncovers Novel Aging Biology and Drug Candidates for Human Healthspan Extension 2020/07/10. Nicolas Perrot, William Pelletier, Jerome Bourgeault, Christian Couture, Zhonglin Li, Patricia Mitchell, Nooshin Ghodsian, Yohan Bosse, Sebastien Theriault, Patrick Mathieu, Benoit J Arsenault. DOI 10.1101/2020.07.06.20147520

Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2 American Journal of Respiratory and Critical Care Medicine, 2020/06/15. Guoshuai Cai, Yohan Bossé, Feifei Xiao, Farrah Kheradmand, Christopher I. Amos. DOI 10.1164/rccm.202003-0693LE

Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved] 2020/06/01. Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, Louise V. Wain. DOI 10.12688/wellcomeopenres.15846.1

Protein-altering germline mutations implicate novel genes related to lung cancer development Nature Communications, 2020/05/11. Xuemei Ji, Semanti Mukherjee, Maria Teresa Landi, Yohan Bosse, Philippe Joubert, Dakai Zhu, Ivan Gorlov, Xiangjun Xiao, Younghun Han, Olga Gorlova, Rayjean J. Hung, Yonathan Brhane, Robert Carreras-Torres, David C. Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeböller, Melinda C. Aldrich, William S. Bush, Adonina Tardon, Gad Rennert, Chu Chen, Jinyoung Byun, Konstantin H. Dragnev, John K. Field, Lambertus FA. Kiemeney, Philip Lazarus, Shan Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Pier A. Bertazzi, Angela C. Pesatori, Nancy Diao, Li Su, Lei Song, Ruyang Zhang, Natasha Leighl, Jakob S. Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H. F. M. van der Heijden, Jin Hee Kim, Michael P. A. Davies, Michael W. Marcus, Hans Brunnström, Jonas Manjer, Olle Melander, David C. Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Gary E. Goodman, Angela Cox, Fiona Taylor, Penella Woll, Erich Wichmann, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M. Arnold, Eric B. Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M. Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Lesley M. Butler, Kenneth Offit, Preethi Srinivasan, Chaitanya Bandlamudi, Matthew D. Hellmann, David B. Solit, Mark E. Robson, Charles M. Rudin, Zsofia K. Stadler, Barry S. Taylor, Michael F. Berger, Richard Houlston, John McLaughlin, Victoria Stevens, David C. Nickle, Ma’en Obeidat, Wim Timens, María Soler Artigas, Sanjay Shete, Hermann Brenner, Stephen Chanock, Paul Brennan, James D. McKay, Christopher I. Amos. DOI 10.1038/s41467-020-15905-6

Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases Communications Biology, 2020/05/01. Arnaud Chignon, Valentin Bon-Baret, Marie-Chloé Boulanger, Zhonglin Li, Deborah Argaud, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu. DOI 10.1038/s42003-020-0937-x

Transcriptome‐wide association study reveals candidate causal genes for lung cancer International Journal of Cancer, 2020/04. Yohan Bossé, Zhonglin Li, Jun Xia, Venkata Manem, Robert Carreras‐Torres, Aurélie Gabriel, Nathalie Gaudreault, Demetrius Albanes, Melinda C. Aldrich, Angeline Andrew, Susanne Arnold, Heike Bickeböller, Stig E. Bojesen, Paul Brennan, Hans Brunnstrom, Neil Caporaso, Chu Chen, David C. Christiani, John K. Field, Gary Goodman, Kjell Grankvist, Richard Houlston, Mattias Johansson, Mikael Johansson, Lambertus A. Kiemeney, Stephen Lam, Maria T. Landi, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Olle Melander, Gadi Rennert, Angela Risch, Susan M. Rosenberg, Matthew B. Schabath, Sanjay Shete, Zhuoyi Song, Victoria L. Stevens, Adonina Tardon, H‐Erich Wichmann, Penella Woll, Shan Zienolddiny, Ma'en Obeidat, Wim Timens, Rayjean J. Hung, Philippe Joubert, Christopher I. Amos, James D. McKay. DOI 10.1002/ijc.32771

Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q Cancer Epidemiology, Biomarkers & Prevention, 2020/02/01. Anthony M. Musolf, Bilal A. Moiz, Haiming Sun, Claudio W. Pikielny, Yohan Bossé, Diptasri Mandal, Mariza de Andrade, Colette Gaba, Ping Yang, Yafang Li, Ming You, Ramaswamy Govindan, Richard K. Wilson, Elena Y. Kupert, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson. DOI 10.1158/1055-9965.EPI-19-0887

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility Nature Communications, 2020/01/07. Linda Kachuri, Mattias Johansson, Sara R. Rashkin, Rebecca E. Graff, Yohan Bossé, Venkata Manem, Neil E. Caporaso, Maria Teresa Landi, David C. Christiani, Paolo Vineis, Geoffrey Liu, Ghislaine Scelo, David Zaridze, Sanjay S. Shete, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardón, Gad Rennert, Chu Chen, Gary E. Goodman, Jennifer A. Doherty, Heike Bickeböller, John K. Field, Michael P. Davies, M. Dawn Teare, Lambertus A. Kiemeney, Stig E. Bojesen, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Loïc Le Marchand, Iona Cheng, Matthew B. Schabath, Eric J. Duell, Angeline S. Andrew, Jonas Manjer, Philip Lazarus, Susanne Arnold, James D. McKay, Nima C. Emami, Matthew T. Warkentin, Yonathan Brhane, Ma’en Obeidat, Richard M. Martin, Caroline Relton, George Davey Smith, Philip C. Haycock, Christopher I. Amos, Paul Brennan, John S. Witte, Rayjean J. Hung. DOI 10.1038/s41467-019-13855-2

High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma Journal of Lipid Research, 2019/10/13. Anne-Marie Lemay, Olivier Courtemanche, Timothy A. Couttas, Giuleta Jamsari, Andréanne Gagné, Yohan Bossé, Philippe Joubert, Anthony S. Don, David Marsolais. DOI 10.1194/jlr.M093955

A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity npj Genomic Medicine, 2019/09/20. Mickael Rosa, Arnaud Chignon, Zhonglin Li, Marie-Chloé Boulanger, Benoit J. Arsenault, Yohan Bossé, Sébastien Thériault, Patrick Mathieu. DOI 10.1038/s41525-019-0097-4

Benefits and limitations of genome-wide association studies Nature Reviews Genetics, 2019/08/08. Vivian Tam, Nikunj Patel, Michelle Turcotte, Yohan Bossé, Guillaume Paré, David Meyre. DOI 10.1038/s41576-019-0127-1

Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD European Respiratory Journal, 2019/07. Maarten van den Berge, Corry-Anke Brandsma, Alen Faiz, Maaike de Vries, Senani N.H. Rathnayake, Peter D. Paré, Don D. Sin, Yohan Bossé, Michel Laviolette, David C. Nickle, Ke Hao, Ma'en Obeidat, Tommaso A. Dragani, Francesca Colombo, Wim Timens, Dirkje S. Postma. DOI 10.1183/13993003.02567-2017

UCP1 expression–associated gene signatures of human epicardial adipose tissue JCI Insight, 2019/04/18. Kanta Chechi, Jinchu Vijay, Pierre Voisine, Patrick Mathieu, Yohan Bossé, Andre Tchernof, Elin Grundberg, Denis Richard. DOI 10.1172/jci.insight.123618